ToxSci Advance Access published online on May 12, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh161
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
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1 Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
* To whom correspondence should be addressed. E-mail: gwelleni{at}hsph.harvard.edu.
Ambient air pollution is a complex mixture of particulate matter (PM) and gaseous pollutants such as carbon monoxide (CO). The effect of exposure to CO, alone or in combination with ambient PM, on arrhythmia incidence is unclear. To evaluate these effects, left-ventricular myocardial infarction was induced in Sprague-Dawley rats by thermocoagulation. Diazepamsedated rats were exposed (1h) to either filtered air (n=40), CO (35 ppm, n=19), concentrated air particles (CAPs, median concentration=350.5 µg/m3, n=53), or CAPs and CO (CAPs median concentration=318.2 µg/m3, n=23), 12-18h after surgery. Each exposure was immediately preceded and followed by a 1h exposure to filtered air (pre-exposure and post-exposure periods, respectively). The CO target dose of 35 ppm is related to the 1h US National Ambient Air Quality Standard. Surface electrocardiograms were recorded and heart rate and arrhythmia incidence were quantified. CO exposure reduced ventricular premature beat (VPB) frequency by 60.4% (p=0.012) during the exposure period compared to controls. This effect was modified by both infarct type and the number of pre-exposure VPBs, and was not mediated through changes in heart rate. Overall, CAPs exposure increased VPB frequency during the exposure period, but this effect did not reach statistical significance. This effect was modified by the number of pre-exposure VPBs. Overall, neither CAPs nor CO had any effect on heart rate, but CAPs increased heart rate in specific subgroups. No significant interactions were observed between the effects of CO and CAPs. In this animal model, the responses to CO and CAPs are distinctly different.
Accepted April 29, 2004
Environmental Toxicology
Cardiac Effects of Carbon Monoxide and Ambient Particles in a Rat Model of Myocardial Infarction
2 Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115
3 Beth Israel Deaconess Medical Center, Boston, MA 02215; Harvard Medical School, Boston, MA 02115
4 Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115; Harvard Medical School, Boston, MA 02115
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