ToxSci Advance Access published online on May 24, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh174
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
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1 INRS-Institut Armand Frappier, Université du Québec, Montreal, QC, Canada
* To whom correspondence should be addressed. E-mail: daniel.cyr{at}INRS-IAF.uquebec.ca.
Little information exists on the transfer of endocrine disrupting effects through the food chain. The transfer of these chemicals, particularly from the aquatic ecosystem, and their effects to fish-eating predators must be established. Fish from the St. Lawrence River are exposed to xenoestrogens causing male reproductive dysfunction. The objective of this study was to determine if lactational exposure to contaminated fish could alter the development of the male reproductive system in rats. Three experimental groups were used: rats (dams) gavaged with (a) distilled water (control), or (b) homogenized fish from a reference site (Îles de la Paix) or (c) homogenized fish from a xenoestrogen-contaminated site (Îlet Vert). Pups were exposed via lactation and sampled on either day 21 (weaning) or 91 (adults). There was no effect on the body weights or in the male reproductive organ weights between groups except for adult epididymal weights which was significantly decreased in the xenoestrogen group. Adult sperm concentrations and sperm motility parameters were all significantly decreased in the xeonestrogen group as compared to the reference and control groups. Furthermore, the distribution of stages of spermatogenesis was altered in the xenoestrogen group, indicating an effects on the kinetics of spermatogenesis. Immunoreactivity of Connexin43 (Cx43), a gap junctional protein, was markedly decreased in the seminiferous epithelium of the xenoestrogen group suggesting that the intercellular coordination of testicular function may be affected. These data indicate that contaminants from xenoestrogen environments may pass through the food chain and exert effects on male reproductive functions.
Accepted May 11, 2004
Reproductive and Developmental Toxicology
Consumption of Xenoestrogen-Contaminated Fish During Lactation Alters Adult Male Reproductive Function
2 St. Lawrence Centre, Environment Canada, Montreal, QC, Canada
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