Skip Navigation



ToxSci Advance Access published online on July 14, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh219
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
81/2/263    most recent
kfh219v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tydén, E.
Right arrow Articles by Larsson, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tydén, E.
Right arrow Articles by Larsson, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received April 28, 2004
Accepted July 7, 2004

Biotransformation and Toxicokinetics

Metabolic Activation of 2,6-Xylidine in the Nasal Olfactory Mucosa and the Mucosa of the Upper Alimentary and Respiratory Tracts in Rats

Eva Tydén 1, Hans Tjälve 1, Pia Larsson 1*

1 Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden

* To whom correspondence should be addressed. E-mail: Pia.Larsson{at}farmtox.slu.se.


  Abstract

Whole-body low-temperature radioluminography of 3H-2,6-xylidine in rats indicates that the non-metabolized substance, which is a volatile and fat-soluble compound, is distributed throughout the body and accumulates in adipose tissues, e.g. in the abdominal and subcutaneous regions. Whole-body autoradiography with freeze-dried or solvent-extracted tissue-sections as well as microautoradiography, which were used to trace tissues in the rats accumulating 2,6-xylidine-metabolites, showed presence of tissue-bound 2,6-xylidine-metabolites in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts. These tissues were found to have an in vitro-capacity to bioactivate 2,6-xylidine. Our data indicate that 2,6-xylidine in vivo undergoes an in situ bioactivation in these extrahepatic tissues. Our results showed that the nasal olfactory mucosa had a much higher capacity than the other examined tissues to bioactivate 2,6-xylidine. Thus, the carcinogenic effect of 2,6-xylidine towards the nasal mucosa in rats is correlated to a high capacity of this tissue to bioactivate the compound.

Keywords: 2,6-xylidine; metabolic activation; nasal olfactory mucosa; alimentary tract; respiratory tract; nasal cancer.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.