Skip Navigation



ToxSci Advance Access published online on August 25, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh263
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
82/2/614    most recent
kfh263v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Crowell, J. A.
Right arrow Articles by Levine, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crowell, J. A.
Right arrow Articles by Levine, B. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received May 28, 2004
Accepted August 20, 2004

Safety Evaluation

Resveratrol Associated Renal Toxicity

James A. Crowell 1*, Peter J. Korytko 2, Robert L. Morrissey 3, Tristan D. Booth 4, Barry S. Levine 2

1 Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892-7322
2 Toxicology Research Laboratory, University of Illinois, Chicago, IL 60612-7353
3 Pathology Associates, a Charles River Company, Chicago, IL 60612-7353
4 Royalmount Pharmaceuticals Inc., Montreal, Quebec, Canada H4P 2T4

* To whom correspondence should be addressed. E-mail: jc94h{at}nih.gov.


  Abstract

Resveratrol, (3,5,4'-trihydoxystilbene) a compound found in grapes, mulberries, and peanuts, has antimycotic, antiviral, and beneficial cardiovascular and cancer preventive activities. It is being developed for several clinical indications. To evaluate the potential toxicity of resveratrol, rats were administered by gavage 0, 300, 1000, and 3000 mg trans-resveratrol per kilogram body weight per day for 4 weeks. Most of the adverse events occurred in the rats administered 3000 mg per kilogram body weight per day. These included increased clinical signs of toxicity; reduced final body weights and food consumption; elevated BUN, creatinine, alkaline phosphatase, alanine aminotransferase, total bilirubin, and albumin; reduced hemoglobin, hematocrit, and red cell counts; and increased white cell counts. Increases in kidney weights and clinically significant renal lesions, including an increased incidence and severity of nephropathy, were observed. Diffuse epithelial hyperplasia in the bladder was considered, equivocal and of limited biological significance. No histological effects on the liver were observed, despite the clinical chemistry changes and increased liver weights in the females. Effects seen in the group administered 1000 mg resveratrol per kilogram body weight per day included reduced body weight gain (females only) and elevated white blood cell count (males only). Plasma resveratrol concentrations in blood collected 1 hour after dose administration during week 4 were dose-related but were relatively low given the high dosage levels; conjugates were not measured. Under the conditions of this study, the no observed adverse effect level was 300 mg resveratrol per kilogram body weight per day in rats.

Keywords: Resveratrol; Cancer Chemoprevention; Kidney.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
P. D. A. Issuree, P. N. Pushparaj, S. Pervaiz, and A. J. Melendez
Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities
FASEB J, August 1, 2009; 23(8): 2412 - 2424.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
V Eybl, D Kotyzova, P Cerna, and J Koutensky
Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
Human and Experimental Toxicology, April 1, 2008; 27(4): 347 - 353.
[Abstract] [PDF]

Home page
 Nutr Clin PractHome page
J. O. Clarke and G. E. Mullin
A Review of Complementary and Alternative Approaches to Immunomodulation
Nutr Clin Pract, February 1, 2008; 23(1): 49 - 62.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Bhardwaj, G. Sethi, S. Vadhan-Raj,, C. Bueso-Ramos, Y. Takada, U. Gaur, A. S. Nair, S. Shishodia, and B. B. Aggarwal
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
Blood, March 15, 2007; 109(6): 2293 - 2302.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H. Shapiro, P. Singer, Z. Halpern, and R. Bruck
Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis
Gut, March 1, 2007; 56(3): 426 - 436.
[Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
A. KASDALLAH-GRISSA, B. MORNAGUI, E. AOUANI, M. HAMMAMI, N. GHARBI, A. KAMOUN, and S. EL-FAZAA
PROTECTIVE EFFECT OF RESVERATROL ON ETHANOL-INDUCED LIPID PEROXIDATION IN RATS
Alcohol Alcohol., May 1, 2006; 41(3): 236 - 239.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. E. Juan, E. Gonzalez-Pons, T. Munuera, J. Ballester, J. E. Rodriguez-Gil, and J. M. Planas
trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats
J. Nutr., April 1, 2005; 135(4): 757 - 760.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.