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ToxSci Advance Access published online on September 29, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh293
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
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Received September 7, 2004
Accepted September 22, 2004

Forum

Human Carcinogenic Risk Evaluation, Part V: The National Toxicology Program Vision for Assessing the Human Carcinogenic Hazard of Chemicals

John R. Bucher 1* and Christopher Portier 1

1 National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709

* To whom correspondence should be addressed. E-mail: bucher{at}niehs.nih.gov.


  Abstract

The National Toxicology Program (NTP) has over 25 years of experience in the design, performance and interpretation of assays for identifying carcinogenic hazards to humans. Through the years we have examined alternative assays and adjunct assays to the standard rodent cancer bioassay including batteries of genetic toxicity tests and genetically modified mouse models. As our collective understanding of carcinogenesis advances, toxicologists and regulatory scientists will at some point begin to rely on mechanism-based biological observations rather than the 2-year rodent bioassay to predict human cancer hazards. The goal of the NTP Vision for the 21st Century is to develop the science base that will advance the use of mechanism-based biological observations, eventually providing a replacement for disease-specific toxicology models in the protection of public health.

Keywords: Carcinogen identification; approach; mechanism-based biological observations.
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