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ToxSci Advance Access published online on February 9, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi110
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Toxicological Sciences © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received October 29, 2004
Accepted February 4, 2005

Review

Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity

Adrian J. Hill 1, Hiroki Teraoka 2, Warren Heideman 3, and Richard E. Peterson 3*

1 School of Pharmacy, University of Wisconsin, Madison, WI, USA
2 Department of Toxicology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan
3 School of Pharmacy, University of Wisconsin, Madison, WI, USA; Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA

* To whom correspondence should be addressed.
Richard E. Peterson, E-mail: repeterson{at}pharmacy.wisc.edu


  Abstract

Zebrafish (Danio rerio ) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and elucidating mechanisms of toxicity are highlighted.


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