Skip Navigation



ToxSci Advance Access published online on April 13, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi167
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
86/1/194    most recent
kfi167v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hsiao, S.-H.
Right arrow Articles by Haschek., W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsiao, S.-H.
Right arrow Articles by Haschek., W. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received February 9, 2005
Accepted April 1, 2005

Systems Toxicology

Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulmonary Arterial Rings

Shih-Hsuan Hsiao 1*, Peter D. Constable 2, Geoffrey W. Smith 3, and Wanda M. Haschek. 1

1 Department of Veterinary Pathobiology College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
2 Department of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
3 Department of Veterinary Clinical Medicine College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA; Department of Veterinary Pathobiology College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA

* To whom correspondence should be addressed.
Shih-Hsuan Hsiao, E-mail: shsiao1{at}uiuc.edu


  Abstract

Fumonisin mycotoxicosis in pigs causes a decrease in mean aortic pressure, an increase in mean pulmonary arterial pressure and increases in serum concentrations of sphinganine (3.2 µM) and sphingosine (1.4 µM). To determine a causal relationship between the hemodynamic changes and sphingolipid alterations, we examined the in vitro effects of sphinganine, sphingosine, and sphingosine-1-phosphate on porcine aortic and pulmonary arterial rings. Both sphinganine and sphingosine relaxed uncontracted and phenylephrine-contracted aortic rings at >10 µM and >1 µM, respectively. Sphingosine (>10 µM) relaxed uncontracted and phenylephrine-contracted pulmonary arterial rings, whereas sphingosine-1-phosphate (10 µM) contracted pulmonary arterial rings. Sphingosine (3 µM) also impaired the contractile response of pulmonary artery rings to 60 mM KCl. The results suggested that the systemic hypotension caused by fumonisin is mediated, in part, by increases in serum sphinganine and sphingosine concentrations, and the pulmonary hypertension is mediated, in part, by increased sphingosine-1-phosphate concentrations.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 FASEB J.Home page
K. R. Watterson, K. M. Berg, D. Kapitonov, S. G. Payne, A. S. Miner, R. Bittman, S. Milstien, P. H. Ratz, and S. Spiegel
Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone
FASEB J, September 1, 2007; 21(11): 2818 - 2828.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Lorenz, L. J. Arend, R. Robitz, R. J. Paul, and A. J. MacLennan
Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R440 - R446.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
R. T. Riley and K. A. Voss
Differential Sensitivity of Rat Kidney and Liver to Fumonisin Toxicity: Organ-Specific Differences in Toxin Accumulation and Sphingoid Base Metabolism
Toxicol. Sci., July 1, 2006; 92(1): 335 - 345.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.