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ToxSci Advance Access published online on April 20, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi174
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Toxicological Sciences © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received February 17, 2005
Accepted April 13, 2005

Neurotoxicology

COPLANAR PCB CONGENERS INCREASE UTERINE WEIGHT AND FRONTAL CORTICAL DOPAMINE IN THE DEVELOPING RAT: IMPLICATIONS FOR DEVELOPMENTAL NEUROTOXICITY

Richard F. Seegal 1* and Karl O. Brosch 2

1 New York State Department of Health, Wadsworth Center, Box 509, Albany, New York 12201-0509; University at Albany, School of Public Health, Box 509, Albany, New York 12201-0509
2 New York State Department of Health, Wadsworth Center, Box 509, Albany, New York 12201-0509

* To whom correspondence should be addressed.
Richard F. Seegal, E-mail: seegal{at}wadsworth.org


  Abstract

We show that developmental exposure of the laboratory rat to the coplanar polychlorinated biphenyl (PCB) congener 3,4,3',4'-tetrachlorobiphenyl (TCB) and the structurally similar congener 3,4,5,3',4'-pentachlorobiphenyl (PtCB) elevates dopamine (DA) concentrations in the prefrontal cortex (PFC). In order to determine whether these co-planar congeners are estrogenic, and may thus contribute to the elevations in PFC DA, we measured uterine wet weight (UWW) in prepubertal rats exposed to TCB or PtCB. For comparison, additional animals were exposed to either the ortho-substituted congener 2,4,2',4'-tetrachlorobiphenyl (o-TCB) or 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), a coplanar congener highly resistant to metabolism. Both TCB and PtCB increased UWW, but this effect was blocked following exposure to the anti-estrogen ICI 182,780. Neither o-TCB nor HCB altered UWW. These results demonstrate that certain coplanar PCB congeners and/or their metabolites, are estrogenic and suggest that exposure during critical periods of neuronal development may increase central DA concentrations, and by inference, alter behavior.

Keywords: polychlorinated biphenyls; coplanar; uterotropic; brain; dopamine; developmental neurotoxicity.
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