Skip Navigation



ToxSci Advance Access published online on June 23, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi236
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
87/1/3    most recent
kfi236v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Aylward, L. L.
Right arrow Articles by Lewis, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aylward, L. L.
Right arrow Articles by Lewis, S. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received March 2, 2005
Accepted June 15, 2005

Review

Issues in Risk Assessment for Developmental Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Compounds

Lesa L. Aylward M.S.1*, James C. Lamb Ph.D., D.A.B.T.2, and Steven C. Lewis Ph.D.3

1 Exponent, Inc., 1800 Diagonal Road, Suite 300, Alexandria, Virginia 22314; 571.227.7221 (phone); 571.227.7299 (fax)
2 The Weinberg Group, 1220 Nineteenth St, NW, Suite 300, Washington, DC 20036-2400
3 Integrative Policy & Science, Inc., 14 Merlin Drive, Washington, New Jersey 07882

* To whom correspondence should be addressed.
Lesa L. Aylward, E-mail: laylward{at}exponent.com


  Abstract

Recent risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds have focused on adverse effects observed in rodent offspring exposed while in utero during critical gestational periods as among the most sensitive adverse effects attributable to TCDD exposure. In addition, these risk assessments have converged on the use of body concentration (or "body burden") of TCDD as a dose metric superior to administered dose for cross-species comparisons and risk assessments due to the interspecies differences in elimination kinetics and substantial persistence of these compounds. The detailed, although incomplete, data that are available on maternal-fetal distribution of TCDD and related compounds illustrate differences in distribution among these compounds that impact assessments on a body burden basis. These data also demonstrate differences in distribution after subchronic or chronic administration compared to acute administration. Some data are now also available addressing inconsistencies that may arise from the use of TCDD toxic equivalency factors (TEFs), which were derived on an administered dose basis, in evaluating responses to mixtures of dioxins on a body burden basis in the context of chronic exposure situations. Finally, the use of body burden as a dose metric does not account for or eliminate the substantial differences in sensitivity to dioxin observed across species or between different strains of the same species, and thus does not eliminate the need to consider the relative sensitivity of humans compared to laboratory animal models in risk assessments. Additional research areas that may increase the foundation for interspecies extrapolations are discussed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
D. R. Bell, S. Clode, M. Q. Fan, A. Fernandes, P. M. D. Foster, T. Jiang, G. Loizou, A. MacNicoll, B. G. Miller, M. Rose, et al.
Relationships between Tissue Levels of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and Toxicity in the Developing Male Wistar(Han) Rat
Toxicol. Sci., October 1, 2007; 99(2): 591 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
P Guzelian, L Quattrochi, N Karch, L Aylward, and R Kaley
Does dioxin exert toxic effects in humans at or near current background body levels?: an evidence-based conclusion
Human and Experimental Toxicology, February 1, 2006; 25(2): 99 - 105.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.