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ToxSci Advance Access published online on August 17, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi277
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received May 25, 2005
Accepted August 2, 2005

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In Silico Methods for Evaluating Human Allergenicity to Novel Proteins: International Bioinformatics Workshop Meeting Report February 23-24, 2005

Karluss Thomas 1*, Gary Bannon 2, Susan Hefle 3, Corinne Herouet 4, Michael Holsapple 1, Gregory Ladics 5, Sue MacIntosh 6, and Laura Privalle 7

1 International Life Sciences Institute Health and Environmental Sciences Institute, One Thomas Circle NW, Ninth Floor, Washington, DC 20005
2 Monsanto Co. 800 North Lindbergh Boulevard, St. Louis, MO 63167
3 Food Allergy Research and Resource Program, University of Nebraska, 255 Food Industry Building, Lincoln, NE 68583
4 Bayer CropScience, Regulatory Toxicology, 355 rue Doistoïevski, Sophia Antipolis, France
5 E.I. Dupont De Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, P.O. Box 50 1090 Elkton Road, Newark, DE 19714
6 Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709
7 BASF Plant Science, 26 Davis Drive, Research Triangle Park, NC 27709

* To whom correspondence should be addressed.
Karluss Thomas, E-mail: kthomas{at}ilsi.org


  Abstract

The ILSI Health and Environmental Sciences Institute (HESI) hosted an expert workshop February 22-24, 2005 in Mallorca, Spain, to review the state-of-the-science for conducting a sequence homology/bioinformatics evaluation in the context of a comprehensive allergenicity assessment for novel proteins, to obtain consensus on the value and role of bioinformatics in evaluating novel proteins, and to discuss the utility and methods of allergen specific IgE testing in the diagnosis of food allergy. The workshop participants included over forty international experts from academia, industry, and government. The workshop was hosted by the HESI Protein Allergenicity Technical committee which has established a long-term program whose mission is to advance the scientific understanding of the relevant parameters for characterizing the allergenic potential of novel proteins.

Keywords: allergy; antibody; antigen; IgE; food allergy; immunoglobulin.
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