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ToxSci Advance Access published online on August 24, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfi293
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 13, 2005
Accepted August 17, 2005

Forum

Research Strategies for Safety Evaluation of Nanomaterials: Part 2, Toxicological and Safety Evaluation of Nanomaterials: Current Challenges and Data Needs

Michael P. Holsapple 1, William H. Farland 2, Timothy D. Landry 3, Nancy A. Monteiro-Riviere 4, Janet M. Carter 5, Nigel J. Walker 6, and Karluss V. Thomas 1*

1 ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, DC 20005
2 Office of Research and Development, US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, Washington, DC 20460
3 Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Building 1803, Midland, MI 48674
4 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606
5 Central Product Safety, Procter & Gamble Co, Miami Valley Labs, PO Box 538707, Cincinnati, OH 45253
6 National Institute of Environmental Health Sciences, 11 Alexander Drive, Research Triangle Park, NC 27709

* To whom correspondence should be addressed.
Karluss V. Thomas, E-mail: kthomas{at}ilsi.org


  Abstract

This article summarizes a roundtable discussion held at the 2005 Society of Toxicology Annual Meeting held in New Orleans, LA. The purpose of the roundtable was to review the current challenges and data needs for conducting toxicological and safety evaluations for nanomaterials, with the goals of presenting the current state-of-the science on the safety of nanomaterials and bringing together scientists representing government, academia, and industry to identify priorities for developing data to facilitate risk assessments for these materials. In this summary, the unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them. In addition, the development of appropriate hazard data, the collection of accurate human and environmental exposure information, and the development of a better fundamental understanding of the modes of action for nanomaterials are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.

Keywords: nanomaterials; nanoscale materials; nanotechnology; risk assessment; toxicology.

Disclaimer: The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the institutions represented by the authors.


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