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ToxSci Advance Access published online on October 12, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfj015
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 15, 2005
Accepted October 5, 2005

Reproductive and Developmental Toxicology

Sub-chronic Exposure to Dibromoacetic Acid, a Water Disinfection Byproduct, Does Not Affect Gametogenic Potential in Mice

N.M. Weber 1, H.R. Sawyer 1, M.E. Legare 2, and D.N.R. Veeramachaneni 1*

1 Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523-1683
2 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1683

* To whom correspondence should be addressed.
D.N.R. Veeramachaneni, E-mail: rao{at}colostate.edu


  Abstract

Water disinfection byproducts, such as dibromoacetic acid (DBA), are formed when drinking water is treated with chlorination, bromination or ozonation. Epidemiological studies have linked these byproducts to adverse effects in humans such as cancer, developmental defects and reproductive toxicities. DBA has been shown to produce reproductive toxicity in rodents at relatively high doses. The present study used a mouse model to determine the developmental and reproductive effects of sub-chronic, low dose exposure to DBA. Pregnant mice (10/dose group) were exposed with DBA in drinking water at 0, 5 or 50 mg/kg/day from gestation day 15 though nursing. Upon weaning at 3 wk, one group of pups (pre-pubertal group: 7-10 pups of each gender/treatment group) were euthanized and weights of liver, paired kidneys, testes and ovaries were measured. In the 50 mg dose group, weights of testes and liver in males and weights of liver and kidneys in females were significantly higher (p<0.05). The remaining pups (15-17 of each gender/dose group) continued to be dosed similarly through adulthood. At 7 wk of age (neo-pubertal group), animals were euthanized and tissues weighed and processed for evaluation of reproductive organs and gametogenic potential. Except for decreased (p<0.05) testes and kidney weights in 50 mg dose group males, there were no differences in organ weights. No significant differences were noted between control and dosed animals in daily sperm production, testicular sperm counts, epididymal sperm reserves, morphology of seminiferous epithelium, or ovarian follicle counts.

Keywords: Dibromoacetic acid; ovary; follicles; testis; sperm; mouse.
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[Abstract] [Full Text] [PDF]


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