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ToxSci Advance Access published online on October 12, 2005
Toxicological Sciences, doi:10.1093/toxsci/kfj018
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 30, 2005
Accepted October 8, 2005

Review

Toxicogenomics in Risk Assessment: Applications and Needs

Darrell R Boverhof 1 and Timothy R Zacharewski 1*

1 Department of Biochemistry and Molecular Biology and Center for Integrative Toxicology, Michigan State University, East Lansing MI, USA

* To whom correspondence should be addressed.
Timothy R Zacharewski, E-mail: tzachare{at}msu.edu


  Abstract

Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable insights into toxic mechanisms of action. However, the application of these data into risk assessment practices is still in the early stages of development and proof of principle experiments have yet to emerge. The following discusses some potential applications as well as impediments that warrant a concerted investigation from all stakeholders in order to facilitate the acceptance and subsequent incorporation of toxicogenomics into regulatory decision making.


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