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ToxSci Advance Access published online on January 11, 2006
Toxicological Sciences, doi:10.1093/toxsci/kfj098
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© The Author 2006. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 30, 2005
Accepted January 9, 2006

Biotransformation and Toxicokinetics

Disposition of BDE 47 in Developing Mice

DF Staskal 1 *, JJ Diliberto 2, and LS Birnbaum 2

1 UNC Curriculum in Toxicology, 3420 Executive Center Drive, Suite 114, Austin, TX 78731
2 US EPA, ORD, NHEERL, ETD, US EPA, MD B143-01, 109 TW Alexander Dr. Research Triangle Park, NC 27711

* To whom correspondence should be addressed.
DF Staskal, E-mail: dstaskal{at}chemrisk.com


  Abstract

Despite its minor contribution to global PBDE production and usage, 2,2',4,4'tetrabromodiphenyl ether (BDE 47) is the dominant congener found in most biotic samples in North America. The majority of public health concern has focused on potential hazardous effects resulting from exposure of infants and young children to BDE 47 because of previous studies reporting adverse developmental effects in rodent studies in combination with human exposure estimates suggesting that nursing infants and young children have the highest exposure to BDE 47. This study is designed with two objectives: 1) to investigate the disposition of BDE 47 in infantile mice reported to be susceptible to BDE 47 and 2) to investigate the disposition and excretion of BDE 47 at various developmental stages in an attempt to further identify the mechanism responsible for rapid urinary excretion. The disposition of [14C]BDE 47 was monitored in C57BL/6 mice following a single oral dose of BDE 47 (1 mg/kg) at different stages of development. The results show that the toxicokinetics of BDE 47 are different in developing mice than in adult mice; while disposition patterns are similar, concentrations of BDE 47 are higher in pups due to a reduced capacity to excrete BDE 47. These differences lead to higher concentrations of BDE 47 at target tissues during critical windows of development.

Keywords: BFR; PBDE; BDE 47; toxicokinetics.
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