ToxSci Advance Access published online on March 16, 2006
Toxicological Sciences, doi:10.1093/toxsci/kfj160
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1 DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
* To whom correspondence should be addressed. The absorption, distribution, metabolism, and elimination of [3-14C] 8-2 Fluorotelomer Alcohol (8-2 FTOH, C7F15 14CF2CH2CH2OH) following a single oral dose at 5 and 125 mg/kg in male and female rats has been determined. Following oral dosing, the maximum concentration of 8-2 FTOH in plasma occurred by 1 hour post-dose and cleared rapidly with a t1/2 of less than 5 hours. The internal dose to 8-2 FTOH, as measured by AUCinf, was similar for male and female rats and was observed to increase in a dose-dependent fashion. The majority of the 14C 8-2 FTOH (>70%) was excreted in feces and 37-55% was identified as parent. Less than 4% of the administered dose was excreted in urine, which contained low concentrations of perfluorooctanoate (
Received January 15, 2006
Accepted March 3, 2006
Biotransformation and Toxicokinetics
Absorption, Distribution, Metabolism, and Elimination of 8-2 Fluorotelomer Alcohol in the Rat
William J. Fasano 1 *,
Stephen C. Carpenter 1,
Shawn A. Gannon 1,
Timothy A. Snow 1,
Judith C. Stadler 1,
Gerald L. Kennedy 1,
Robert C. Buck 2,
Stephen H. Korzeniowski 2,
Paul M. Hinderliter 3,
and
Raymond A. Kemper 4
2 DuPont Chemical Solutions Enterprise Wilmington, Delaware, USA
3 Current Affiliation: Battelle Pacific Northwest, Richland, Washington, USA
4 Current Affiliation: Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA
William J. Fasano, E-mail: william.j.fasano{at}usa.dupont.com
Abstract 
1% of total 14C). Metabolites identified in bile were principally composed of glucuronide and glutathione conjugates, and perfluorohexanoate was identified in excreta and plasma demonstrating metabolism of the parent fluorotelomer alcohol by sequential removal of multiple CF2 groups. At 7-days post dose, 4%-7% of the administered radioactivity was present in tissues, and for the majority, 14C concentrations were greater than whole blood with the highest concentration in fat, liver, thyroid, and adrenals. Distribution and excretion of a single 125-mg/kg [3-14C] 8-2 FTOH dermal dose following a six-hour exposure in rats was also determined. The majority of the dermal dose either volatilized from the skin (37%) or was removed by washing (29%). Following a 6-hour dermal exposure and a seven-day collection period, excretion of total radioactivity via urine (<0.1%) and feces (<0.2%) was minor and radioactivity concentrations in most tissues were below limit of detection. Systemic availability of 8-2 FTOH following dermal exposure was negligible.
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