Skip Navigation



ToxSci Advance Access published online on September 12, 2006
Toxicological Sciences, doi:10.1093/toxsci/kfl106
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
94/2/351    most recent
kfl106v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Guilarte, T. R.
Right arrow Articles by Schneider, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guilarte, T. R.
Right arrow Articles by Schneider, J. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 13, 2006
Accepted September 9, 2006

Neurotoxicology

Evidence for Cortical Dysfunction and Widespread Manganese Accumulation in the Non-Human Primate Brain following Chronic Manganese Exposure: A 1H-MRS and MRI study

Tomás R. Guilarte 1 *, Jennifer L. McGlothan 1, Mahaveer Degaonkar 2, Ming-Kai Chen 1, Peter B. Barker 2, Tore Syversen 3, and Jay S. Schneider 4

1 Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore Maryland
2 Department of Radiology, Johns Hopkins Hospital, Baltimore Maryland
3 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
4 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania

* To whom correspondence should be addressed.
Tomás R. Guilarte, E-mail: tguilart{at}jhsph.edu


  Abstract

Exposure to high levels of manganese (Mn) is known to produce a complex neurological syndrome with psychiatric disturbances, cognitive impairment and parkinsonian features. However, the neurobiological basis of chronic low-level Mn exposure is not well defined. We now provide evidence that exposure to levels of Mn that results in blood Mn concentrations in the upper range of environmental and occupational exposures and in certain medical conditions produces widespread Mn accumulation in the non-human primate brain as visualized by T1-weighted MRI. Analysis of regional brain Mn distribution using a "pallidal index equivalent" indicates that this approach is not sensitive to changing levels of brain Mn measured in post-mortem tissue. Evaluation of longitudinal 1H-MRS data revealed a significant decrease (p= 0.028) in the N-acetylaspartate (NAA)/creatine (Cr) ratio in the parietal cortex and a near significant decrease (p= 0.055) in frontal white matter at the end of the Mn exposure period relative to baseline. Choline/Cr or myo-Inositol/Cr ratios did not change at any time during Mn exposure. This indicates that the changes in the NAA/Cr ratio in the parietal cortex are not due to changes in Cr but in NAA levels. In summary, these findings suggest that during chronic Mn exposure a significant amount of the metal accumulates not only in the basal ganglia but also in white matter and in cortical structures where it is likely to produce toxic effects. This is supported by a significantly decreased in the parietal cortex NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction. (249 words)

Keywords: manganese; MRI; MRS; non-human primate; brain; basal ganglia; N-acetylaspartate.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.