ToxSci Advance Access published online on September 15, 2006
Toxicological Sciences, doi:10.1093/toxsci/kfl109
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1 Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, S-752 36, Uppsala, Sweden
* To whom correspondence should be addressed. The present study shows that polybrominated diphenyl ethers (PBDEs) and PCBs can interact and enhance developmental neurobehavioral defects when the exposure occurs during a critical stage of neonatal brain development. PBDEs are used in large quantities as flame-retardant additives in polymers, especially in the manufacture of a great variety of electrical appliances, and textiles. In contrast to the well-known persistent compounds PCBs and DDT, the PBDEs have been found to increase in the environment and in human mother's milk. We have previously shown that low-dose exposure to environmental toxic agents such as PCB can cause developmental neurotoxic effects when present during a critical stage of neonatal brain development. Epidemiological studies indicate the adverse neurobehavioral impact of PCBs. Recently we reported that neonatal exposure to PBDEs causes developmental neurotoxic effects. In the present study ten-day-old NMRI male mice were given one single oral dose of either PCB 52 (1.4 µmol/kg body weight) + PBDE 99 (1.4 µmol), PCB 52 (1.4 µmol or 14 µmol), PBDE 99 (1.4 µmol or 14 µmol). Controls received a vehicle (20% fat emulsion). Animals exposed to the combined dose of PCB 52 (1.4 µmol) + PBDE 99 (1.4 µmol), and the high dose of PCB 52 (14 µmol) or PBDE 99 (14 µmol) showed significantly impaired spontaneous motor behaviour and habituation capability at the age of 4 and 6 months. The neurobehavioral defects were also seen to worsen with age in mice neonatally exposed to PCB 52 + PBDE 99.
Received June 1, 2006
Accepted September 11, 2006
Environmental Toxicology
Polybrominated Diphenyl Ethers (PBDEs), a Group of Brominated Flame Retardants, can Interact with PCB in Enhancing Developmental Neurobehavioral Defects
Per Eriksson 1 *, Celia Fischer 1, and Anders Fredriksson 1
Per Eriksson, E-mail: per.eriksson{at}ebc.uu.se
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