Skip Navigation



ToxSci Advance Access published online on September 27, 2006
Toxicological Sciences, doi:10.1093/toxsci/kfl117
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
95/1/281    most recent
kfl117v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Roberts, S. M.
Right arrow Articles by Ruby, M. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roberts, S. M.
Right arrow Articles by Ruby, M. V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 6, 2006
Accepted September 18, 2006

Risk Assessment

Relative Oral Bioavailability of Arsenic from Contaminated Soils Measured in the Cynomolgus Monkey

Stephen M. Roberts 1 *, John W. Munson 1, Yvette W Lowney 2, and Michael V. Ruby 2

1 Center for Environmental & Human Toxicology, University of Florida, Gainesville, FL 32611, U.S.A.
2 Exponent, Boulder, CO 80301, U.S.A.

* To whom correspondence should be addressed.
Stephen M. Roberts, E-mail: smr{at}ufl.edu


  Abstract

A number of studies have found that GI absorption of arsenic from soil is limited, indicating that a relative oral bioavailability (RBA) adjustment is warranted when calculating risks from exposure to arsenic contaminated soil. However, few studies of arsenic bioavailability from soil have been conducted in animal models with phylogenetic similarity to humans, such as non-human primates. We report here the results of a study in which the RBA of arsenic in soil from a variety of types of contaminated sites was measured in male cynomolgus monkeys. A single oral dose of each contaminated soil was administered to five adult male cynomolgus monkeys by gavage, and the extent of oral absorption was evaluated through measurement of arsenic recovery in urine and feces. Urinary recovery of arsenic following doses of contaminated soil were compared with urinary recovery following oral administration of sodium arsenate in water in order to determine the RBA of each soil. RBA of arsenic in 14 soil samples from 12 different sites ranged from 0.05 to 0.31 (5 to 31%), with most RBA values in the 0.1 to 0.2 (10 to 20%) range. The RBA values were found to be inversely related to the amount of arsenic present with iron sulfate. No other significant correlations were observed between RBA and arsenic mineralogic phases in the test soils. The lack of clear relationships between arsenic mineralogy and RBA measured in vivo suggests that gastrointestinal absorption of arsenic from soil may be more complex than originally thought, and subject to factors other than simple dissolution behavior.

Keywords: arsenic; oral bioavailability; contaminated soil; non-human primates.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Can MineralHome page
S. R. Walker, M. B. Parsons, H. E. Jamieson, and A. Lanzirotti
ARSENIC MINERALOGY OF NEAR-SURFACE TAILINGS AND SOILS: INFLUENCES ON ARSENIC MOBILITY AND BIOACCESSIBILITY IN THE NOVA SCOTIA GOLD MINING DISTRICTS
Can Mineral, June 1, 2009; 47(3): 533 - 556.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
L. C. B. Crouse, M. W. Michie, M. A. Major, G. J. Leach, and G. Reddy
Oral Bioavailability of Cyclotrimethylenetrinitramine (RDX) from Contaminated Site Soils in Rats
International Journal of Toxicology, July 1, 2008; 27(4): 317 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
Y. W. Lowney, R. C. Wester, R. A. Schoof, C. A. Cushing, M. Edwards, and M. V. Ruby
Dermal Absorption of Arsenic from Soils as Measured in the Rhesus Monkey
Toxicol. Sci., December 1, 2007; 100(2): 381 - 392.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.