ToxSci Advance Access published online on March 15, 2007
Toxicological Sciences, doi:10.1093/toxsci/kfm053
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Published by Oxford University Press 2007.
Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine Ige and Airway Hyperreactivity Response to Ovalbumin
PFOA Enhances OVA Induced Allergic Response
1 National Institute for Occupational Safety and Health, Morgantown, WV 26505, B.J. Meade's email: jmeade{at}cdc.gov 2 Baldur Toxicology, N7659 950th St. River Falls WI 54022
Corresponding Author: B. Jean Meade, 1095 Willowdale Road, MS 4020, Morgantown, WV 26505, Phone: (304) 285-5809. E-mail: bhm8{at}cdc.gov
Received January 18, 2007; revision received March 7, 2007; accepted March 8, 2007
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Abstract |
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These studies were conducted to investigate the role of dermal exposure to Perfluorooctanoic acid (PFOA), a known immunosuppressant, on the hypersensitivity response to ovalbumin in a murine model of asthma. PFOA has had widespread use as a carpet and fabric protectant. BALB/c mice were exposed dermally, on the dorsal surface of each ear, to concentrations of PFOA ranging from 0.01-1.5% (applied dose 0.25-50 mg/kg) for 4 days. In hypersensitivity studies, mice were also intraperitoneally injected with 7.5 µg ovalbumin and 2 mg alum on days 1 and 10 and in some studies, challenged with 250 µg ovalbumin by pharyngeal aspiration on days 17 and 26. Following exposure to PFOA, an increase in liver weights and a decrease in thymus and spleen weights and cellularities were observed. Similar immunomodulatory trends were demonstrated in mice co-administered PFOA and ovalbumin (OVA). Compared to the OVA alone exposed animals, an increase in total IgE was demonstrated when mice were co-exposed to OVA and concentrations of PFOA ranging from 0.75-1.5%, while the OVA-specific IgE response peaked with 0.75% PFOA co-exposure (p 
0.05). OVA-specific airway hyperreactivity was increased in the 1.0% PFOA co-exposed group (p 0.05), with an increased pleiotropic cell response characterized by eosinophilia and mucin production, in animals co-exposed to concentrations of PFOA up to 1.0%, as compared to the ovalbumin alone exposed animals. In a murine model, PFOA was demonstrated to be immunotoxic following dermal exposure, with an enhancement of the hypersensitivity response to ovalbumin, suggesting that PFOA exposure may augment the IgE response to environmental allergens.
Key Words: Perfluorooctanoic acid; Ovalbumin; Airway Hyperreactivity; IgE.
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