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ToxSci Advance Access published online on July 16, 2007
Toxicological Sciences, doi:10.1093/toxsci/kfm171
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Neurotoxic Potential of Depleted Uranium - Effects in Primary Cortical Neuron Cultures and in Caenorhabditis elegans

George C.-T. Jiang*, Kristen Tidwell{dagger}, BethAnn McLaughlin{ddagger}, Jiyang Cai§, Ramesh C. Gupta, Dejan Milatovic||, Richard Nass||| and Michael Aschner||||

* Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083. cjiang{at}wfubmc.edu {dagger} Department of Neurology, Vanderbilt University, Nashville, TN 37232. kristenloveless{at}hotmail.com {ddagger} Department of Neurology, Vanderbilt University, Nashville, TN 37232. BethAnn.Mclaughlin{at}vanderbilt.edu § Vanderbilt Eye Institute, Vanderbilt University, Nashville, TN 37232. Jiyang.Cai{at}vanderbilt.edu Toxicology Department, Murray State University, Hopkinsville, KY 42240. Ramesh.Gupta{at}murraystate.edu || Department of Pediatrics, Vanderbilt University, Nashville, TN 37232. Dejan.Milatovic{at}vanderbilt.edu ||| Department of Pediatrics, Vanderbilt University, Nashville, TN 37232. Richard.Nass{at}vanderbilt.edu |||| Department of Pediatrics, Vanderbilt University, Nashville, TN 37232. Michael.Aschner{at}vanderbilt.edu

Address correspondence and reprint requests to Michael Aschner, Ph.D., Departments of Pediatrics and Pharmacology, and the Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, 6110 MRBIII, 465 21st Ave S, Nashville, TN 37232-2495, USA. Telephone: (615) 322-8024; Fax: (615) 322-6541; e-mail: michael.aschner{at}vanderbilt.edu

Received April 17, 2007; revision received June 12, 2007; accepted June 13, 2007


  Abstract

Depleted uranium (DU) is an extremely dense metal that is used in radiation shielding, counterbalances, armor and ammunition. In light of the public concerns about exposure to DU and its potential role in Gulf War Syndrome, this study evaluated the neurotoxic potential of DU using focused studies on primary rat cortical neurons and the nematode C. elegans. We examined cell viability, cellular energy metabolism, thiol metabolite oxidation, and lipid peroxidation following exposure of cultured neurons to DU, in the form of uranyl acetate. We concurrently evaluated the neurotoxicity of uranyl acetate in C. elegans using various neuronal-green fluourescent protein reporter strains to visualize neurodegeneration. Our studies indicate that uranyl acetate has low cytotoxic potential, and uranium exposure does not result in significant changes in cellular energy metabolism, thiol metabolite oxidation, or lipid peroxidation. Furthermore, our C. elegans studies do not show any significant neurodegeneration following uranyl acetate exposure. Together, these studies suggest that DU, in the form of uranyl acetate, has low neurotoxic potential. These findings should alleviate the some of public concerns regarding depleted uranium as an etiologic agent of neurodegenerative conditions associated with Gulf War Syndrome.

Key Words: Depleted Uranium; Primary Neurons; Neurotoxicity; Gulf War Syndrome; C. elegans.


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[Abstract] [Full Text] [PDF]


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