ToxSci Advance Access published online on August 13, 2007
Toxicological Sciences, doi:10.1093/toxsci/kfm202
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High Dietary Inorganic Phosphate Affects Lung Through Altering Protein Translation, Cell cycle, And Angiogenesis in Developing Mice
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Laboratory of Toxicology, College of Veterinary Medicine
Nano Systems Institute-National Core Research Center, Seoul National University, Seoul 151-742, Korea
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea
¶ Department of Food Science & Technology, Chungnam National University, Taejeon, Korea
Laboratory of Molecular Oncology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea
* Corresponding author, Myung-Haing Cho, D.V.M., Ph.D., Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea, E-mail: mchotox{at}snu.ac.kr
Received April 30, 2007; revision received August 1, 2007; accepted August 2, 2007
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Abstract |
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Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Several studies indicate that Pi may affect lung cell development through Na/Pi co-transporter (NPT). Several NPT subtypes have been identified in mammalian lung and considerable progress has been made in our understanding of their function and regulation. Therefore, current study was performed to elucidate the potential effects of high dietary Pi on lungs of developing mice. Our results clearly demonstrate that high dietary Pi may affect the lung of developing mice through Akt-related cap-dependent protein translation, cell cycle regulation, and angiogenesis. Our results support the hypothesis that Pi works as a critical signal molecule for normal lung growth and suggest that careful restriction of Pi consumption may be important in maintaining a normal development.
# Equal contribution to this work
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