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ToxSci Advance Access first published online on August 28, 2007
This version published online on September 6, 2007
Toxicological Sciences, doi:10.1093/toxsci/kfm221
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with Se-methylselenocysteine in mice

Jinsong Zhang*, Xufang Wang and Tongwen Xu

University of Science and Technology of China, Hefei 230052, Anhui, PR China

* Corresponding author. School of Chemistry and Material Science, University of Science and Technology of China, Southern Campus, Meiling Avenue No.121, Hefei, 230052, Anhui, P.R.China. Tel: +86 551 3492386, Fax: +86 551 3492386. E-mail address: zjszyzzc{at}mail.hf.ah.cn

Received May 15, 2007; revision received July 12, 2007; accepted July 20, 2007


  Abstract

As an essential trace element with a narrow margin between beneficial and toxic effects and as a promising chemopreventive agent needed to be consumed for a long term, the toxicity of selenium is always a crucial concern. Based on the clinical findings and the recent studies in selenoprotein gene-modified mice, it is likely that the antioxidant function of one or more selenoproteins is responsible for the chemopreventive effect. Furthermore, upregulation of phase 2 enzymes by selenium has frequently been the focus of chemopreventive mechanism at supranutritional dietary levels. Se-methylselenocysteine (SeMSC), a nature-occurring organic selenium product, is considered as one of the most effective chemopreventive selenocompounds. Present study revealed, as compared with SeMSC, elemental selenium at nano size (Nano-Se) possessed equal efficacy in increasing the activities of glutathione peroxidase, thioredoxin reductase and glutathione S-transferase but had much lower toxicity as indicated by median lethal dose, acute liver injury, survival rate and short-term toxicity. Our results suggest Nano-Se can serve as a potential chemopreventive agent with reduced risk of selenium toxicity.

Key Words: Nano-Se; Se-methylselenocysteine; Toxicity; Bioavailability; Selenoenzymes; Glutathione S-transferase.

This vision of the article has updated figures, tables and acknowledgements.


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