Skip Navigation



ToxSci Advance Access published online on February 16, 2008
Toxicological Sciences, doi:10.1093/toxsci/kfn030
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
105/2/235    most recent
kfn030v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hotckiss, A. K.
Right arrow Articles by Gray, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hotckiss, A. K.
Right arrow Articles by Gray, L. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2008.

Fifteen years after "Wingspread"- Environmental Endocrine Disrupters and human and wildlife health: Where we are today and where we need to go.

A. K. Hotckiss{dagger},*, C. V. Rider{dagger},*, C. R. Blystone{dagger},*, V. S. Wilson{dagger}, P. C. Hartig{dagger}, G. T. Ankley{ddagger}, P. M. Foster§, C. L. Gray** and L. E. Gray{dagger},¶

{dagger} Reproductive Toxicology Division, Endocrinology Branch, MD 72, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711 {ddagger} Mid-continent Division, Toxic Effects Characterization Research Branch, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, MN 55804 § Toxicology Operations Branch, NIH/NIEHS, P.O. Box 12233, Research Triangle Park, North Carolina 27709 * USEPA/NCSU Cooperative Training agreement (CT826512010), Raleigh, NC 27695 ** Geography Department, University of North Carolina at Chapel Hill

To whom correspondence should be sent: above address, or phone (919-541-7750) or fax (919-541-4017), or email: gray.earl{at}epa.gov

Received December 22, 2007; revision received January 31, 2008; accepted February 8, 2008


  Abstract

In 1991 a group of expert scientists at a Wingspread work session on endocrine disrupting chemicals (EDCs) concluded that "Many compounds introduced into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Endocrine disruption can be profound because of the crucial role hormones play in controlling development." Since that time, there have been numerous documented examples of adverse effects of EDCs in invertebrates, fish, wildlife, domestic animals, and humans. Hormonal systems can be disrupted by numerous different anthropogenic chemicals including anti-androgens, androgens, estrogens, AhR agonists, inhibitors of steroid hormone synthesis, antithyroid substances, and retinoid agonists. In addition, pathways and targets for endocrine disruption extend beyond the traditional estrogen/androgen/thyroid (EAT) receptor-mediated reproductive and developmental systems. For example, scientists have expressed concern about the potential role of EDCs in increasing trends in early puberty in girls, obesity and type II diabetes in the US and other populations. New concerns include complex endocrine alterations induced by mixtures of chemicals, an issue broadened due to the growing awareness that EDCs present in the environment include a variety of potent human and veterinary pharmaceutical products, personal care products, nutraceuticals and phytosterols. In this review we 1) address what have we learned about the effects of EDCs on fish, wildlife, and human health, 2) discuss representative animal studies on (anti)androgens, estrogens and TCDD-like chemicals, and 3) evaluate regulatory proposals being considered for screening and testing these chemicals.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ScienceHome page
M. R. Schwarzman and M. P. Wilson
New Science for Chemicals Policy
Science, November 20, 2009; 326(5956): 1065 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc AHome page
S. R. Smith
Organic contaminants in sewage sludge (biosolids) and their significance for agricultural recycling
Phil Trans R Soc A, October 13, 2009; 367(1904): 4005 - 4041.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
J. L. Flippin, J. M. Hedge, M. J. DeVito, G. A. LeBlanc, and K. M. Crofton
Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine
International Journal of Toxicology, September 1, 2009; 28(5): 368 - 381.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
L. E. Gray Jr, N. J. Barlow, K. L. Howdeshell, J. S. Ostby, J. R. Furr, and C. L. Gray
Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter
Toxicol. Sci., August 1, 2009; 110(2): 411 - 425.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.