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ToxSci Advance Access published online on June 11, 2008
Toxicological Sciences, doi:10.1093/toxsci/kfn116
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition

Min He*,{dagger}, Jiyang Cai{ddagger}, Young-Mi Go*, Jennifer M. Johnson*,{dagger}, W. David Martin§, Jason M. Hansen and Dean P. Jones*

* Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine {dagger} Graduate Program in Nutrition Health Science § Transgenic Mouse Facility Division of Pulmonary, Allergy, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University, Atlanta, GA 30322 USA {ddagger} Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232 USA

Address correspondence to: Dr. Dean P. Jones, Department of Medicine, 205 Whitehead Research Center, Emory University, Atlanta, GA 30322. Phone: 404-727-5970; Fax; 404-712-2974; E-mail: dpjones{at}emory.edu

Received March 29, 2008; revision received June 4, 2008; accepted June 5, 2008


  Abstract

Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic (Tg) mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca2+ in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.

Key Words: Transgenic mice; cell death mechanisms; apoptosis; necrosis; calcium.


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