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ToxSci Advance Access published online on April 8, 2009
Toxicological Sciences, doi:10.1093/toxsci/kfp059
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© The Author 2009. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

A toxicology for the 21st century – mapping the road ahead

Thomas Hartung

Johns Hopkins University, Bloomberg School of Public Health, Department for Environmental Health Sciences, Center for Alternatives to Animal Testing, Chair for Evidence-based Toxicology, Baltimore, USA

Thartung{at}jhsph.edu

Received February 19, 2009; revision received March 13, 2009; accepted March 13, 2009


  Abstract

The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centres on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, i.e. the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the NAS report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together.

Key Words: toxicity testing; Methods; Risk Assessment.


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