Toxicological Sciences

EDITORIAL

Gary Wright Miller

Paraquat: The Red Herring of Parkinson's Disease Research
Toxicol. Sci. 2007 100: 1-2; doi:10.1093/toxsci/kfm223 [Extract] [Full Text] [PDF] [Request Permissions]  

PROFILES IN TOXICOLOGY

R. Michael McClain and Bernard M. Wagner

Emil Alvin Pfitzer
Toxicol. Sci. 2007 100: 3-4; doi:10.1093/toxsci/kfm237 [Extract] [Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT

Robert Francis Stachlewitz

Bringing Biomarkers to the Masses: An Elegant Approach to Discover Potential Biomarkers of Vascular Injury
Toxicol. Sci. 2007 100: 5-6; doi:10.1093/toxsci/kfm228 [Extract] [Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Moshe Szyf

The Dynamic Epigenome and its Implications in Toxicology
ToxSci Advance Access published on August 3, 2007
Toxicol. Sci. 2007 100: 7-23; doi:10.1093/toxsci/kfm177 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Charles D. N. Humfrey

Recent Developments in the Risk Assessment of Potentially Genotoxic Impurities in Pharmaceutical Drug Substances
ToxSci Advance Access published on July 26, 2007
Toxicol. Sci. 2007 100: 24-28; doi:10.1093/toxsci/kfm173 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract June K. Dunnick, Kristina A. Thayer, and Gregory S. Travlos

Inclusion of Biomarkers for Detecting Perturbations in the Heart and Lung and Lipid/Carbohydrate Metabolism in National Toxicology Program Studies
ToxSci Advance Access published on May 8, 2007
Toxicol. Sci. 2007 100: 29-35; doi:10.1093/toxsci/kfm113 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Balázs Németi and Zoltán Gregus

Glutathione-Dependent Reduction of Arsenate by Glycogen Phosphorylase—A Reaction Coupled to Glycogenolysis
ToxSci Advance Access published on August 9, 2007
Toxicol. Sci. 2007 100: 36-43; doi:10.1093/toxsci/kfm211 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Zoltán Gregus and Balázs Németi

Glutathione-Dependent Reduction of Arsenate by Glycogen Phosphorylase—Responsiveness to Endogenous and Xenobiotic Inhibitors
ToxSci Advance Access published on August 9, 2007
Toxicol. Sci. 2007 100: 44-53; doi:10.1093/toxsci/kfm212 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Helen Tinwell, Claire Friry-Santini, David Rouquié, Sara Belluco, Laetitia Elies, Catherine Pallen, and Remi Bars

Evaluation of the Antiandrogenic Effects of Flutamide, DDE, and Linuron in the Weanling Rat Assay Using Organ Weight, Histopathological, and Proteomic Approaches
ToxSci Advance Access published on August 8, 2007
Toxicol. Sci. 2007 100: 54-65; doi:10.1093/toxsci/kfm208 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Shang-Lun Chiang, Shih-Sheng Jiang, Yi-Jou Wang, Horn-Che Chiang, Ping-Ho Chen, Hung-Pin Tu, Kun-Yen Ho, Yu-Shan Tsai, I-Shou Chang, and Ying-Chin Ko

Characterization of Arecoline-Induced Effects on Cytotoxicity in Normal Human Gingival Fibroblasts by Global Gene Expression Profiling
ToxSci Advance Access published on August 6, 2007
Toxicol. Sci. 2007 100: 66-74; doi:10.1093/toxsci/kfm201 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Angeline S. Andrew, Viviane Bernardo, Linda A. Warnke, Jennifer C. Davey, Thomas Hampton, Rebecca A. Mason, Jessica E. Thorpe, Michael A. Ihnat, and Joshua W. Hamilton

Exposure to Arsenic at Levels Found in U.S. Drinking Water Modifies Expression in the Mouse Lung
ToxSci Advance Access published on August 6, 2007
Toxicol. Sci. 2007 100: 75-87; doi:10.1093/toxsci/kfm200 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Markus Alexander Zettner, Susanne Flor, Gabriele Ludewig, Jörg Wagner, Larry W. Robertson, and Leane Lehmann

Quinoid Metabolites of 4-Monochlorobiphenyl Induce Gene Mutations in Cultured Chinese Hamster V79 Cells
ToxSci Advance Access published on August 8, 2007
Toxicol. Sci. 2007 100: 88-98; doi:10.1093/toxsci/kfm204 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Aimen K. Farraj, Elizabeth Boykin, Najwa Haykal-Coates, Stephen H. Gavett, Donald Doerfler, and MaryJane Selgrade

Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice
ToxSci Advance Access published on August 9, 2007
Toxicol. Sci. 2007 100: 99-108; doi:10.1093/toxsci/kfm194 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Shiuh-Inn Liu, Chorng-Chih Huang, Chun-Jen Huang, Being-Whey Wang, Po-Min Chang, Yi-Chien Fang, Wei-Chuan Chen, Jue-Long Wang, Yih-Chau Lu, Sau-Tung Chu, Chiang-Ting Chou, and Chung-Ren Jan

Thimerosal-Induced Apoptosis in Human SCM1 Gastric Cancer Cells: Activation of p38 MAP Kinase and Caspase-3 Pathways without Involvement of [Ca²⁺]_i Elevation
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 109-117; doi:10.1093/toxsci/kfm205 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Shirley X. Guo-Ross, Janice E. Chambers, Edward C. Meek, and Russell L. Carr

Altered Muscarinic Acetylcholine Receptor Subtype Binding in Neonatal Rat Brain following Exposure to Chlorpyrifos or Methyl Parathion
ToxSci Advance Access published on July 31, 2007
Toxicol. Sci. 2007 100: 118-127; doi:10.1093/toxsci/kfm195 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lester G. Sultatos

Concentration-Dependent Binding of Chlorpyrifos Oxon to Acetylcholinesterase
ToxSci Advance Access published on August 16, 2007
Toxicol. Sci. 2007 100: 128-135; doi:10.1093/toxsci/kfm197 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract He Li, Lawrence M. Schopfer, Florian Nachon, Marie-Thérèse Froment, Patrick Masson, and Oksana Lockridge

Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 136-145; doi:10.1093/toxsci/kfm215 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Vernon A. Benignus, William K. Boyes, Elaina M. Kenyon, and Philip J. Bushnell

Quantitative Comparisons of the Acute Neurotoxicity of Toluene in Rats and Humans
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 146-155; doi:10.1093/toxsci/kfm203 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David S. Barber, Stanley Stevens, and Richard M. LoPachin

Proteomic Analysis of Rat Striatal Synaptosomes during Acrylamide Intoxication at a Low Dose Rate
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 156-167; doi:10.1093/toxsci/kfm210 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Jedd Michael Hillegass, Caren Melissa Villano, Keith Raymond Cooper, and Lori Anne White

Matrix Metalloproteinase-13 Is Required for Zebra fish (Danio rerio) Development and Is a Target for Glucocorticoids
ToxSci Advance Access published on August 28, 2007
Toxicol. Sci. 2007 100: 168-179; doi:10.1093/toxsci/kfm192 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maria E. Jönsson, Matthew J. Jenny, Bruce R. Woodin, Mark E. Hahn, and John J. Stegeman

Role of AHR2 in the Expression of Novel Cytochrome P450 1 Family Genes, Cell Cycle Genes, and Morphological Defects in Developing Zebra Fish Exposed to 3,3',4,4',5-Pentachlorobiphenyl or 2,3,7,8-Tetrachlorodibenzo-p-dioxin
ToxSci Advance Access published on August 8, 2007
Toxicol. Sci. 2007 100: 180-193; doi:10.1093/toxsci/kfm207 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Susan C. Laws, Tammy E. Stoker, Janet M. Ferrell, Michelle G. Hotchkiss, and Ralph L. Cooper

Effects of Altered Food Intake during Pubertal Development in Male and Female Wistar Rats
ToxSci Advance Access published on August 28, 2007
Toxicol. Sci. 2007 100: 194-202; doi:10.1093/toxsci/kfm219 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Leah A. Mitchell, Jun Gao, Randy Vander Wal, Andrew Gigliotti, Scott W. Burchiel, and Jacob D. McDonald

Pulmonary and Systemic Immune Response to Inhaled Multiwalled Carbon Nanotubes
ToxSci Advance Access published on July 28, 2007
Toxicol. Sci. 2007 100: 203-214; doi:10.1093/toxsci/kfm196 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Hua Jin, Seung-Hee Chang, Cheng-Xiong Xu, Ji-Young Shin, Youn-Sun Chung, Sung-Jin Park, Yeon-Sook Lee, Gil-Hwan An, Kee-Ho Lee, and Myung-Haing Cho

High Dietary Inorganic Phosphate Affects Lung through Altering Protein Translation, Cell Cycle, and Angiogenesis in Developing Mice
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 215-223; doi:10.1093/toxsci/kfm202 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Brent D. Kerger, Hon-Wing Leung, Paul K. Scott, and Dennis J. Paustenbach

An Adaptable Internal Dose Model for Risk Assessment of Dietary and Soil Dioxin Exposures in Young Children
ToxSci Advance Access published on August 6, 2007
Toxicol. Sci. 2007 100: 224-237; doi:10.1093/toxsci/kfm199 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Nicolas Daguès, Valérie Pawlowski, Cécile Sobry, Gilles Hanton, Françoise Borde, Sylvain Soler, Jean-Louis Freslon, and Stephan Chevalier

Investigation of the Molecular Mechanisms Preceding PDE4 Inhibitor-Induced Vasculopathy in Rats: Tissue Inhibitor of Metalloproteinase 1, a Potential Predictive Biomarker
ToxSci Advance Access published on June 14, 2007
Toxicol. Sci. 2007 100: 238-247; doi:10.1093/toxsci/kfm161 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Crystal R. Waites, Mark A. Dominick, Thomas P. Sanderson, and Beth E. Schilling

Nonclinical Safety Evaluation of Muraglitazar, a Novel PPAR/ Agonist
ToxSci Advance Access published on August 4, 2007
Toxicol. Sci. 2007 100: 248-258; doi:10.1093/toxsci/kfm193 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Patrick J. Shaw, Marie J. Hopfensperger, Patricia E. Ganey, and Robert A. Roth

Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha
ToxSci Advance Access published on August 19, 2007
Toxicol. Sci. 2007 100: 259-266; doi:10.1093/toxsci/kfm218 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Francis F. Tukov, James P. Luyendyk, Patricia E. Ganey, and Robert A. Roth

The Role of Tumor Necrosis Factor Alpha in Lipopolysaccharide/Ranitidine-Induced Inflammatory Liver Injury
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 267-280; doi:10.1093/toxsci/kfm209 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Paul A. Dabisch, Michael S. Horsmon, William T. Muse, Robert J. Mioduszewski, and Sandra Thomson

Muscarinic Receptor Dysfunction Induced by Exposure to Low Levels of Soman Vapor
ToxSci Advance Access published on August 9, 2007
Toxicol. Sci. 2007 100: 281-289; doi:10.1093/toxsci/kfm213 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Masatomo Rokushima, Kazuo Omi, Kae Imura, Akiko Araki, Naoko Furukawa, Fumio Itoh, Masako Miyazaki, Junko Yamamoto, Makiko Rokushima, Manabu Okada, Mikinori Torii, Ikuo Kato, and Jun Ishizaki

Toxicogenomics of Drug-Induced Hemolytic Anemia by Analyzing Gene Expression Profiles in the Spleen
ToxSci Advance Access published on August 13, 2007
Toxicol. Sci. 2007 100: 290-302; doi:10.1093/toxsci/kfm216 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Debamitra Dutta, Shanmugavelayutham Kamakshi Sundaram, Justin Gary Teeguarden, Brian Joseph Riley, Leonard Sheldon Fifield, Jon Morrell Jacobs, Shane Raymond Addleman, George Alan Kaysen, Brij Mohan Moudgil, and Thomas Joseph Weber

Adsorbed Proteins Influence the Biological Activity and Molecular Targeting of Nanomaterials
ToxSci Advance Access published on August 19, 2007
Toxicol. Sci. 2007 100: 303-315; doi:10.1093/toxsci/kfm217 [Abstract] [Full Text] [PDF] [Request Permissions]  

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