Cover illustration. Immunohistochemical detection of hepatocyte proliferation in control and WY-14,643-treated wildtype and humanized PPARα mice (hPPARαPAC). WY-14,643 caused the expected increase in hepatocyte proliferation whereas no change in cell proliferation was noted in the hPPARαPAC mice. Work by Yang et al. to describe the biological response of the humanized PPARα mouse model to xenobiotics is highlighted in this issue (pp 132-139).
[Table of Contents]