Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

David A. Basketter

Nonanimal Alternatives for Skin Sensitization: A Step Forward?
Toxicol. Sci. 2008 102: 1-2; doi:10.1093/toxsci/kfm299 [Extract] [Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Melvin E. Andersen, John L. Butenhoff, Shu-Ching Chang, David G. Farrar, Gerald L. Kennedy, Jr, Christopher Lau, Geary W. Olsen, Jennifer Seed, and Kendall B. Wallace

Perfluoroalkyl Acids and Related Chemistries—Toxicokinetics and Modes of Action
ToxSci Advance Access published on November 13, 2007
Toxicol. Sci. 2008 102: 3-14; doi:10.1093/toxsci/kfm270 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Miyoung Yoon and Hugh A. Barton

Predicting Maternal Rat and Pup Exposures: How Different are They?
ToxSci Advance Access published on November 17, 2007
Toxicol. Sci. 2008 102: 15-32; doi:10.1093/toxsci/kfm286 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Grégory Rasier, Anne-Simone Parent, Arlette Gérard, Raphaël Denooz, Marie-Christine Lebrethon, Corinne Charlier, and Jean-Pierre Bourguignon

Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone
ToxSci Advance Access published on November 20, 2007
Toxicol. Sci. 2008 102: 33-41; doi:10.1093/toxsci/kfm285 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Sharon E. Hook, Ann D. Skillman, Banu Gopalan, Jack A. Small, and Irvin R. Schultz

Gene Expression Profiles in Rainbow Trout, Onchorynchus mykiss, Exposed to a Simple Chemical Mixture
ToxSci Advance Access published on December 15, 2007
Toxicol. Sci. 2008 102: 42-60; doi:10.1093/toxsci/kfm293 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Anna K. Kopec, Darrell R. Boverhof, Lyle D. Burgoon, Daher Ibrahim-Aibo, Jack R. Harkema, Colleen Tashiro, Brock Chittim, and Timothy R. Zacharewski

Comparative Toxicogenomic Examination of the Hepatic Effects of PCB126 and TCDD in Immature, Ovariectomized C57BL/6 Mice
ToxSci Advance Access published on November 27, 2007
Toxicol. Sci. 2008 102: 61-75; doi:10.1093/toxsci/kfm289 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jinming Liu, Manisha Ballaney, Umaima Al-alem, Chunli Quan, Ximei Jin, Frederica Perera, Lung-Chi Chen, and Rachel L. Miller

Combined Inhaled Diesel Exhaust Particles and Allergen Exposure Alter Methylation of T Helper Genes and IgE Production In Vivo
ToxSci Advance Access published on November 27, 2007
Toxicol. Sci. 2008 102: 76-81; doi:10.1093/toxsci/kfm290 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Joji Miyawaki, Setsuya Kamei, Kenshi Sakayama, Haruyasu Yamamoto, and Hiroshi Masuno

4-Tert-Octylphenol Regulates the Differentiation of C3H10T1/2 Cells into Osteoblast and Adipocyte Lineages
ToxSci Advance Access published on December 7, 2007
Toxicol. Sci. 2008 102: 82-88; doi:10.1093/toxsci/kfm296 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Sabine Teske, Andrea A. Bohn, Jason P. Hogaboam, and B. Paige Lawrence

Aryl Hydrocarbon Receptor Targets Pathways Extrinsic to Bone Marrow Cells to Enhance Neutrophil Recruitment during Influenza Virus Infection
ToxSci Advance Access published on November 15, 2007
Toxicol. Sci. 2008 102: 89-99; doi:10.1093/toxsci/kfm282 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christal C. Bowman and MaryJane K. Selgrade

Differences in Allergenic Potential of Food Extracts following Oral Exposure in Mice Reflect Differences in Digestibility: Potential Approaches to Safety Assessment
ToxSci Advance Access published on November 21, 2007
Toxicol. Sci. 2008 102: 100-109; doi:10.1093/toxsci/kfm288 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Andreas Natsch and Roger Emter

Skin Sensitizers Induce Antioxidant Response Element Dependent Genes: Application to the In Vitro Testing of the Sensitization Potential of Chemicals
ToxSci Advance Access published on October 11, 2007
Toxicol. Sci. 2008 102: 110-119; doi:10.1093/toxsci/kfm259 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Nagaraj Gopisetty Venkata, Cho S. Aung, Peter J. Cabot, Gregory R. Monteith, and Sarah J. Roberts-Thomson

PPAR and PPARβ Are Differentially Affected by Ethanol and the Ethanol Metabolite Acetaldehyde in the MCF-7 Breast Cancer Cell Line
ToxSci Advance Access published on November 13, 2007
Toxicol. Sci. 2008 102: 120-128; doi:10.1093/toxsci/kfm281 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Francesco Pomati, Chiara Orlandi, Moira Clerici, Fabio Luciani, and Ettore Zuccato

Effects and Interactions in an Environmentally Relevant Mixture of Pharmaceuticals
ToxSci Advance Access published on November 28, 2007
Toxicol. Sci. 2008 102: 129-137; doi:10.1093/toxsci/kfm291 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Sung-Ho Chen, Jen-Kun Lin, Shing-Hwa Liu, Yu-Chih Liang, and Shoei-Yn Lin-Shiau

Apoptosis of Cultured Astrocytes Induced by the Copper and Neocuproine Complex through Oxidative Stress and JNK Activation
ToxSci Advance Access published on December 4, 2007
Toxicol. Sci. 2008 102: 138-149; doi:10.1093/toxsci/kfm292 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Ching-Hua Hsieh, Seng-Feng Jeng, Min-Wei Hsieh, Yi-Chun Chen, Cheng-Shyuan Rau, Tsu-Hsiang Lu, and Shun-Sheng Chen

Statin-Induced Heme Oxygenase-1 Increases NF-B Activation and Oxygen Radical Production in Cultured Neuronal Cells Exposed to Lipopolysaccharide
ToxSci Advance Access published on December 10, 2007
Toxicol. Sci. 2008 102: 150-159; doi:10.1093/toxsci/kfm298 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Jason P. Hogaboam, Amanda J. Moore, and B. Paige Lawrence

The Aryl Hydrocarbon Receptor Affects Distinct Tissue Compartments during Ontogeny of the Immune System
ToxSci Advance Access published on November 17, 2007
Toxicol. Sci. 2008 102: 160-170; doi:10.1093/toxsci/kfm283 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kim J. Fernie, John L. Shutt, Robert J. Letcher, James I. Ritchie, Katrina Sullivan, and David M. Bird

Changes in Reproductive Courtship Behaviors of Adult American Kestrels (Falco sparverius) Exposed to Environmentally Relevant Levels of the Polybrominated Diphenyl Ether Mixture, DE-71
ToxSci Advance Access published on December 7, 2007
Toxicol. Sci. 2008 102: 171-178; doi:10.1093/toxsci/kfm295 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Steven Zuryn, Jujiao Kuang, and Paul Ebert

Mitochondrial Modulation of Phosphine Toxicity and Resistance in Caenorhabditis elegans
ToxSci Advance Access published on November 12, 2007
Toxicol. Sci. 2008 102: 179-186; doi:10.1093/toxsci/kfm278 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Jon G. Wilkes, Bruce S. Hass, Dan A. Buzatu, Lisa M. Pence, Jeffrey C. Archer, Richard D. Beger, Laura K. Schnackenberg, Mary Kim Halbert, Lisa Jennings, and Ralph L. Kodell

Modeling and Assaying Dioxin-Like Biological Effects for both Dioxin-Like and Certain Non-Dioxin–Like Compounds
ToxSci Advance Access published on December 7, 2007
Toxicol. Sci. 2008 102: 187-195; doi:10.1093/toxsci/kfm294 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Lisa D. Beilke, David G. Besselsen, Quiqiong Cheng, Supriya Kulkarni, Angela L. Slitt, and Nathan J. Cherrington

Minimal Role of Hepatic Transporters in the Hepatoprotection against LCA-Induced Intrahepatic Cholestasis
ToxSci Advance Access published on November 20, 2007
Toxicol. Sci. 2008 102: 196-204; doi:10.1093/toxsci/kfm287 [Abstract] [Full Text] [PDF] [Request Permissions]  

CORRIGENDUM

William J. Jo, Alex Loguinov, Michelle Chang, Henri Wintz, Corey Nislow, Adam P. Arkin, Guri Giaever, and Chris D. Vulpe

Identification of Genes Involved in the Toxic Response of Saccharomyces cerevisiae against Iron and Copper Overload by Parallel Analysis of Deletion Mutants
Toxicol. Sci. 2008 102: 205; doi:10.1093/toxsci/kfm307 [Extract] [Full Text] [PDF] [Request Permissions]  

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