Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Oliver Hankinson

Why Does ARNT2 Behave Differently from ARNT?
Toxicol. Sci. 2008 103: 1-3; doi:10.1093/toxsci/kfn032 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEWS

Get checked abstract Shashi K. Ramaiah and Susan Rittling

Pathophysiological Role of Osteopontin in Hepatic Inflammation, Toxicity, and Cancer
ToxSci Advance Access published on September 22, 2007
Toxicol. Sci. 2008 103: 4-13; doi:10.1093/toxsci/kfm246 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Robert J. Kavlock, Gerald Ankley, Jerry Blancato, Michael Breen, Rory Conolly, David Dix, Keith Houck, Elaine Hubal, Richard Judson, James Rabinowitz, Ann Richard, R. Woodrow Setzer, Imran Shah, Daniel Villeneuve, and Eric Weber

Computational Toxicology—A State of the Science Mini Review
ToxSci Advance Access published on December 7, 2007
Toxicol. Sci. 2008 103: 14-27; doi:10.1093/toxsci/kfm297 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Mark R. Fielden, Alex Nie, Michael McMillian, Chandi S. Elangbam, Bruce A. Trela, Yi Yang, Robert T. Dunn, II, Yvonne Dragan, Ronny Fransson-Stehen, Matthew Bogdanffy, Stephen P. Adams, William R. Foster, Shen-Jue Chen, Phil Rossi, Peter Kasper, David Jacobson-Kram, Kay S. Tatsuoka, Patrick J. Wier, Jeremy Gollub, Donald N. Halbert, Alan Roter, Jamie K. Young, Joseph F. Sina, Jennifer Marlowe, Hans-Joerg Martus, Jiri Aubrecht, Andrew J. Olaharski, Nigel Roome, Paul Nioi, Ingrid Pardo, Ron Snyder, Richard Perry, Peter Lord, William Mattes, Bruce D. Car, for the Predictive Safety Testing Consortium, and Carcinogenicity Working Group

Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 28-34; doi:10.1093/toxsci/kfn022 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Hong Lu, Supratim Choudhuri, Kenichiro Ogura, Iván L. Csanaky, Xiaohong Lei, Xingguo Cheng, Pei-zhen Song, and Curtis D. Klaassen

Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR
ToxSci Advance Access published on February 21, 2008
Toxicol. Sci. 2008 103: 35-45; doi:10.1093/toxsci/kfn038 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Mitchell B. Rosen, Janice S. Lee, Hongzu Ren, Beena Vallanat, Jie Liu, Michael P. Waalkes, Barbara D. Abbott, Christopher Lau, and J. Christopher Corton

Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPAR and CAR
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 46-56; doi:10.1093/toxsci/kfn025 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Claudia Montani, Marialetizia Penza, Marija Jeremic, Giorgio Biasiotto, Gina La Sala, Massimo De Felici, Paolo Ciana, Adriana Maggi, and Diego Di Lorenzo

Genistein is an Efficient Estrogen in the Whole-Body throughout Mouse Development
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 57-67; doi:10.1093/toxsci/kfn021 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Min Zhang, Yuping Liang, Xiaohua Zhang, Ying Xu, Heping Dai, and Wei Xiao

Deletion of Yeast CWP Genes Enhances Cell Permeability to Genotoxic Agents
ToxSci Advance Access published on February 16, 2008
Toxicol. Sci. 2008 103: 68-76; doi:10.1093/toxsci/kfn034 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Deborah E. Keil, Tracey Mehlmann, Leon Butterworth, and Margie M. Peden-Adams

Gestational Exposure to Perfluorooctane Sulfonate Suppresses Immune Function in B6C3F1 Mice
ToxSci Advance Access published on February 5, 2008
Toxicol. Sci. 2008 103: 77-85; doi:10.1093/toxsci/kfn015 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Ayako Nakayama, Ivan Riesen, Bernd Köllner, Elisabeth Eppler, and Helmut Segner

Surface Marker-Defined Head Kidney Granulocytes and B Lymphocytes of Rainbow Trout Express Benzo[a]pyrene-Inducible Cytochrome P4501A Protein
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 86-96; doi:10.1093/toxsci/kfn024 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

NEUROTOXICOLOGY

Get checked abstract Vanessa A. Fitsanakis, Na Zhang, Joel G. Anderson, Keith M. Erikson, Malcolm J. Avison, John C. Gore, and Michael Aschner

Measuring Brain Manganese and Iron Accumulation in Rats following 14 Weeks of Low-Dose Manganese Treatment Using Atomic Absorption Spectroscopy and Magnetic Resonance Imaging
ToxSci Advance Access published on January 30, 2008
Toxicol. Sci. 2008 103: 116-124; doi:10.1093/toxsci/kfn019 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Loretta L. Collins, Mary A. Williamson, Bryan D. Thompson, Daniel P. Dever, Thomas A. Gasiewicz, and Lisa A. Opanashuk

2,3,7,8-Tetracholorodibenzo-p-Dioxin Exposure Disrupts Granule Neuron Precursor Maturation in the Developing Mouse Cerebellum
ToxSci Advance Access published on January 27, 2008
Toxicol. Sci. 2008 103: 125-136; doi:10.1093/toxsci/kfn017 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Jing-Ying Huang, Jiunn-Wang Liao, Yi-Chun Liu, Shui-Yuan Lu, Chen-Ping Chou, Wei-Hung Chan, Shee-Uan Chen, and Tzuu-Huei Ueng

Motorcycle Exhaust Induces Reproductive Toxicity and Testicular Interleukin-6 in Male Rats
ToxSci Advance Access published on January 30, 2008
Toxicol. Sci. 2008 103: 137-148; doi:10.1093/toxsci/kfn020 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Lei Zhao, Yuan-Hua Chen, Hua Wang, Yan-Li Ji, Huan Ning, Su-Fang Wang, Cheng Zhang, Jin-Wei Lu, Zi-Hao Duan, and De-Xiang Xu

Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 149-157; doi:10.1093/toxsci/kfn027 [Abstract] [Full Text] [PDF] [Supplementary Data] [Supplementary Data] [Request Permissions]  

Get checked abstract Hou-Chu Yin, Hua-Pin Tseng, Hsin-Yu Chung, Chin-Yi Ko, Wen-Shyong Tzou, Donald R. Buhler, and Chin-Hwa Hu

Influence of TCDD on Zebrafish CYP1B1 Transcription during Development
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 158-168; doi:10.1093/toxsci/kfn035 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Daniel L. Morgan, Gordon P. Flake, Patrick J. Kirby, and Scott M. Palmer

Respiratory Toxicity of Diacetyl in C57Bl/6 Mice
ToxSci Advance Access published on January 27, 2008
Toxicol. Sci. 2008 103: 169-180; doi:10.1093/toxsci/kfn016 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Ok-Nam Bae, Kyung-Min Lim, Jee-Yeon Han, Byoung-In Jung, Jin-Young Lee, Ji-Yoon Noh, Seung-Min Chung, Moo-Yeol Lee, Joo-Young Lee, and Jin-Ho Chung

U-shaped Dose Response in Vasomotor Tone: A Mixed Result of Heterogenic Response of Multiple Cells to Xenobiotics
ToxSci Advance Access published on February 14, 2008
Toxicol. Sci. 2008 103: 181-190; doi:10.1093/toxsci/kfn023 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract Edward J. Dougherty and Richard S. Pollenz

Analysis of Ah Receptor-ARNT and Ah Receptor-ARNT2 Complexes In Vitro and in Cell Culture
ToxSci Advance Access published on December 20, 2007
Toxicol. Sci. 2008 103: 191-206; doi:10.1093/toxsci/kfm300 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Larissa Tercilia Grizzo and Sandra Cordellini

Perinatal Lead Exposure Affects Nitric Oxide and Cyclooxygenase Pathways in Aorta of Weaned Rats
ToxSci Advance Access published on January 30, 2008
Toxicol. Sci. 2008 103: 207-214; doi:10.1093/toxsci/kfn018 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR

Deborah A. Cory-Slechta, Mona Thiruchelvam, and Donato A. Di Monte

Letter regarding: "Paraquat: The Red Herring of Parkinson's Disease Research"
ToxSci Advance Access published on December 27, 2007
Toxicol. Sci. 2008 103: 215-216; doi:10.1093/toxsci/kfm309 [Extract] [Full Text] [PDF] [Request Permissions]  

Gary W. Miller

Paraquat and Parkinson's Disease: Response by Dr. Miller
ToxSci Advance Access published on December 28, 2007
Toxicol. Sci. 2008 103: 217-218; doi:10.1093/toxsci/kfm310 [Extract] [Full Text] [PDF] [Request Permissions]  

Richard M. LoPachin and Terrence Gavin

Response to "Paraquat: The Red Herring of Parkinson's Disease Research"
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 219-221; doi:10.1093/toxsci/kfn028 [Extract] [Full Text] [PDF] [Request Permissions]  

Gary W. Miller

Paraquat and Parkinson's Disease: Response by Dr. Miller, Part II
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 222-223; doi:10.1093/toxsci/kfn029 [Extract] [Full Text] [PDF] [Request Permissions]  

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