Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Joseph L. Borowitz and Gary E. Isom

Nicotine and Type 2 Diabetes
ToxSci Advance Access published on March 18, 2008
Toxicol. Sci. 2008 103: 225-227; doi:10.1093/toxsci/kfn050 [Extract] [Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Alice Hudder and Raymond F. Novak

miRNAs: Effectors of Environmental Influences on Gene Expression and Disease
ToxSci Advance Access published on February 16, 2008
Toxicol. Sci. 2008 103: 228-240; doi:10.1093/toxsci/kfn033 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Rebecca A. Clewell, John J. Kremer, Carla C. Williams, Jerry L. Campbell, Jr, Melvin E. Andersen, and Susan J. Borghoff

Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat following Exposure to Di-n-butylphthalate: Evaluation with a PBPK Model
ToxSci Advance Access published on March 15, 2008
Toxicol. Sci. 2008 103: 241-259; doi:10.1093/toxsci/kfn054 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Philip Marx-Stoelting, Johanna Mahr, Thomas Knorpp, Sandra Schreiber, Markus F. Templin, Thomas Ott, Albrecht Buchmann, and Michael Schwarz

Tumor Promotion in Liver of Mice with a Conditional Cx26 Knockout
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 260-267; doi:10.1093/toxsci/kfn043 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Beth W. Cooper, Taehyeon M. Cho, Peter M. Thompson, and Andrew D. Wallace

Phthalate Induction of CYP3A4 is Dependent on Glucocorticoid Regulation of PXR Expression
ToxSci Advance Access published on March 10, 2008
Toxicol. Sci. 2008 103: 268-277; doi:10.1093/toxsci/kfn047 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Yuanyuan Xu, Yi Wang, Quanmei Zheng, Bing Li, Xin Li, Yaping Jin, Xiuqiang Lv, Guang Qu, and Guifan Sun

Clinical Manifestations and Arsenic Methylation after a Rare Subacute Arsenic Poisoning Accident
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 278-284; doi:10.1093/toxsci/kfn041 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Alhaji N'Jai, Darrell R. Boverhof, Edward Dere, Lyle D. Burgoon, Ying S. Tan, J. Craig Rowlands, Robert A. Budinsky, Kenneth E. Stebbins, and Timothy R. Zacharewski

Comparative Temporal Toxicogenomic Analysis of TCDD- and TCDF-Mediated Hepatic Effects in Immature Female C57BL/6 Mice
ToxSci Advance Access published on March 14, 2008
Toxicol. Sci. 2008 103: 285-297; doi:10.1093/toxsci/kfn053 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jeanine S. Morey, James C. Ryan, Marie-Yasmine Bottein Dechraoui, Amir H. Rezvani, Edward D. Levin, Christopher J. Gordon, John S. Ramsdell, and Frances M. Van Dolah

Liver Genomic Responses to Ciguatoxin: Evidence for Activation of Phase I and Phase II Detoxification Pathways following an Acute Hypothermic Response in Mice
ToxSci Advance Access published on March 18, 2008
Toxicol. Sci. 2008 103: 298-310; doi:10.1093/toxsci/kfn055 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Ochiba M. Lukandu, Daniela E. Costea, Evelyn Neppelberg, Anne C. Johannessen, and Olav K. Vintermyr

Khat (Catha edulis) Induces Reactive Oxygen Species and Apoptosis in Normal Human Oral Keratinocytes and Fibroblasts
ToxSci Advance Access published on February 29, 2008
Toxicol. Sci. 2008 103: 311-324; doi:10.1093/toxsci/kfn044 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Pius Joseph, Quanren He, and Christina Umbright

Heme-oxygenase 1 Gene Expression is a Marker for Hexavalent Chromium-Induced Stress and Toxicity in Human Dermal Fibroblasts
ToxSci Advance Access published on March 10, 2008
Toxicol. Sci. 2008 103: 325-334; doi:10.1093/toxsci/kfn048 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract James A. Dykens, Joseph D. Jamieson, Lisa D. Marroquin, Sashi Nadanaciva, Jinghai J. Xu, Margaret C. Dunn, Arthur R. Smith, and Yvonne Will

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone
ToxSci Advance Access published on March 15, 2008
Toxicol. Sci. 2008 103: 335-345; doi:10.1093/toxsci/kfn056 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Chang-Ning Liu and Chris J. Somps

Na⁺/H⁺ Exchanger-1 Inhibitors Reduce Neuronal Excitability and Alter Na⁺ Channel Inactivation Properties in Rat Primary Sensory Neurons
ToxSci Advance Access published on March 3, 2008
Toxicol. Sci. 2008 103: 346-353; doi:10.1093/toxsci/kfn045 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xiao He, Zhiyong Zhang, Haifeng Zhang, Yuliang Zhao, and Zhifang Chai

Neurotoxicological Evaluation of Long-Term Lanthanum Chloride Exposure in Rats
ToxSci Advance Access published on March 3, 2008
Toxicol. Sci. 2008 103: 354-361; doi:10.1093/toxsci/kfn046 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Jennifer E. Bruin, Hertzel C. Gerstein, Katherine M. Morrison, and Alison C. Holloway

Increased Pancreatic Beta-Cell Apoptosis following Fetal and Neonatal Exposure to Nicotine Is Mediated via the Mitochondria
ToxSci Advance Access published on January 17, 2008
Toxicol. Sci. 2008 103: 362-370; doi:10.1093/toxsci/kfn012 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Eva Rached, Dana Hoffmann, Kai Blumbach, Klaus Weber, Wolfgang Dekant, and Angela Mally

Evaluation of Putative Biomarkers of Nephrotoxicity after Exposure to Ochratoxin A In Vivo and In Vitro
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 371-381; doi:10.1093/toxsci/kfn040 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Michael L. Pritt, David Greg Hall, Justin Recknor, Kelly M. Credille, Donna D. Brown, Nathan P. Yumibe, Albert Eric Schultze, and David E. Watson

Fabp3 as a Biomarker of Skeletal Muscle Toxicity in the Rat: Comparison with Conventional Biomarkers
ToxSci Advance Access published on February 27, 2008
Toxicol. Sci. 2008 103: 382-396; doi:10.1093/toxsci/kfn042 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR

Marcia Hardy and Todd Stedeford

Use of the Pup as the Statistical Unit in Developmental Neurotoxicity Studies: Overlooked Model or Poor Research Design?
Toxicol. Sci. 2008 103: 409-410; doi:10.1093/toxsci/kfn036 [Extract] [Full Text] [PDF] [Request Permissions]  

Per Eriksson

Response to: Use of the Pup as the Statistical Unit in Developmental Neurotoxicity Studies: Overlooked Model or Poor Research Design?
Toxicol. Sci. 2008 103: 411-413; doi:10.1093/toxsci/kfn037 [Extract] [Full Text] [PDF] [Request Permissions]  

José G. Dórea and Rejane C. Marques

Modeling Neurodevelopment Outcomes and Ethylmercury Exposure from Thimerosal-Containing Vaccines
ToxSci Advance Access published on March 25, 2008
Toxicol. Sci. 2008 103: 414-415; doi:10.1093/toxsci/kfn049 [Extract] [Full Text] [PDF] [Request Permissions]  

Robert F. Berman, Issac N. Pessah, Peter R. Mouton, Deepak Mav, and G. Jean Harry

Modeling Neonatal Thimerosal Exposure in Mice
ToxSci Advance Access published on March 25, 2008
Toxicol. Sci. 2008 103: 416; doi:10.1093/toxsci/kfn051 [Extract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2008 103: 417; doi:10.1093/toxsci/kfn069 [Extract] [Full Text] [PDF] [Request Permissions]  

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