Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Ana Navas-Acien and Eliseo Guallar

Measuring Arsenic Exposure, Metabolism, and Biological Effects: The Role of Urine Proteomics
ToxSci Advance Access published on August 18, 2008
Toxicol. Sci. 2008 106: 1-4; doi:10.1093/toxsci/kfn172 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Xingguo Cheng and Curtis D. Klaassen

Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR- and CAR Transcription Factors
ToxSci Advance Access published on July 22, 2008
Toxicol. Sci. 2008 106: 29-36; doi:10.1093/toxsci/kfn147 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xingguo Cheng and Curtis D. Klaassen

Critical Role of PPAR- in Perfluorooctanoic Acid– and Perfluorodecanoic Acid–Induced Downregulation of Oatp Uptake Transporters in Mouse Livers
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 37-45; doi:10.1093/toxsci/kfn161 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David C. Dorman, Melanie F. Struve, Amy Norris, and Alan J. Higgins

Metabolomic Analyses of Body Fluids after Subchronic Manganese Inhalation in Rhesus Monkeys
ToxSci Advance Access published on August 6, 2008
Toxicol. Sci. 2008 106: 46-54; doi:10.1093/toxsci/kfn159 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Adolfo Sierra-Santoyo, Gilberto Castañeda-Hernández, Randy A. Harrison, Hugh A. Barton, and Michael F. Hughes

Pharmacokinetics and Dosimetry of the Antiandrogen Vinclozolin after Oral Administration in the Rat
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 55-63; doi:10.1093/toxsci/kfn167 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Stéphane Pirnay, Bruno Megarbane, Xavier Declèves, Patricia Risède, Stephen W. Borron, Stéphane Bouchonnet, Bérangère Perrin, Marcel Debray, Nathalie Milan, Tania Duarte, Ivan Ricordel, and Frédéric J. Baud

Buprenorphine Alters Desmethylflunitrazepam Disposition and Flunitrazepam Toxicity in Rats
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 64-73; doi:10.1093/toxsci/kfn163 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

HIGHLIGHTED ARTICLE:

Get checked abstract Christine M. Hegedus, Christine F. Skibola, Marcella Warner, Danica R. Skibola, David Alexander, Sophia Lim, Nygerma L. Dangleben, Luoping Zhang, Michael Clark, Ruth M. Pfeiffer, Craig Steinmaus, Allan H. Smith, Martyn T. Smith, and Lee E. Moore

Decreased Urinary Beta-Defensin-1 Expression as a Biomarker of Response to Arsenic
ToxSci Advance Access published on May 28, 2008
Toxicol. Sci. 2008 106: 74-82; doi:10.1093/toxsci/kfn104 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Natallia Shved, Giorgi Berishvili, Jean-François Baroiller, Helmut Segner, and Manfred Reinecke

Environmentally Relevant Concentrations of 17-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish
ToxSci Advance Access published on July 27, 2008
Toxicol. Sci. 2008 106: 93-102; doi:10.1093/toxsci/kfn150 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Fred Tilton and Robert L. Tanguay

Exposure to Sodium Metam during Zebrafish Somitogenesis Results in Early Transcriptional Indicators of the Ensuing Neuronal and Muscular Dysfunction
ToxSci Advance Access published on July 22, 2008
Toxicol. Sci. 2008 106: 103-112; doi:10.1093/toxsci/kfn145 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Anke Lange, Yoshinao Katsu, Rie Ichikawa, Gregory C. Paull, Laura L. Chidgey, Tobias S. Coe, Taisen Iguchi, and Charles R. Tyler

Altered Sexual Development in Roach (Rutilus rutilus) Exposed to Environmental Concentrations of the Pharmaceutical 17-Ethinylestradiol and Associated Expression Dynamics of Aromatases and Estrogen Receptors
ToxSci Advance Access published on July 24, 2008
Toxicol. Sci. 2008 106: 113-123; doi:10.1093/toxsci/kfn151 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Patrick J. Kennedy, Ajay A. Vashisht, Kwang-Lae Hoe, Dong-Uk Kim, Han-Oh Park, Jacqueline Hayles, and Paul Russell

A Genome-Wide Screen of Genes Involved in Cadmium Tolerance in Schizosaccharomyces pombe
ToxSci Advance Access published on August 6, 2008
Toxicol. Sci. 2008 106: 124-139; doi:10.1093/toxsci/kfn153 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Stephan T. Stern, Banu S. Zolnik, Christopher B. McLeland, Jeffery Clogston, Jiwen Zheng, and Scott E. McNeil

Induction of Autophagy in Porcine Kidney Cells by Quantum Dots: A Common Cellular Response to Nanomaterials?
ToxSci Advance Access published on July 15, 2008
Toxicol. Sci. 2008 106: 140-152; doi:10.1093/toxsci/kfn137 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Yvonne Will, James A. Dykens, Sashi Nadanaciva, Brad Hirakawa, Joseph Jamieson, Lisa D. Marroquin, James Hynes, Shem Patyna, and Bart A. Jessen

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells
ToxSci Advance Access published on July 29, 2008
Toxicol. Sci. 2008 106: 153-161; doi:10.1093/toxsci/kfn157 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Cynthia J. Wolf, Margy L. Takacs, Judith E. Schmid, Christopher Lau, and Barbara D. Abbott

Activation of Mouse and Human Peroxisome Proliferator–Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths
ToxSci Advance Access published on August 18, 2008
Toxicol. Sci. 2008 106: 162-171; doi:10.1093/toxsci/kfn166 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Sherin Y. Boctor, Cheng Wang, and Sherry A. Ferguson

Neonatal PCP Is More Potent than Ketamine at Modifying Preweaning Behaviors of Sprague-Dawley Rats
ToxSci Advance Access published on July 30, 2008
Toxicol. Sci. 2008 106: 172-179; doi:10.1093/toxsci/kfn152 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Márcia C. Carvalho, Evelise M. Nazari, Marcelo Farina, and Yara M. R. Muller

Behavioral, Morphological, and Biochemical Changes after In Ovo Exposure to Methylmercury in Chicks
ToxSci Advance Access published on August 6, 2008
Toxicol. Sci. 2008 106: 180-185; doi:10.1093/toxsci/kfn158 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Russell L. Carr and Carole A. Nail

Effect of Different Administration Paradigms on Cholinesterase Inhibition following Repeated Chlorpyrifos Exposure in Late Preweanling Rats
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 186-192; doi:10.1093/toxsci/kfn164 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Adrian C. Grimes, Kyle N. Erwin, Harriett A. Stadt, Ginger L. Hunter, Holly A. Gefroh, Huai-Jen Tsai, and Margaret L. Kirby

PCB126 Exposure Disrupts ZebraFish Ventricular and Branchial but Not Early Neural Crest Development
ToxSci Advance Access published on July 26, 2008
Toxicol. Sci. 2008 106: 193-205; doi:10.1093/toxsci/kfn154 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Camilla Taxvig, Anne Marie Vinggaard, Ulla Hass, Marta Axelstad, Julie Boberg, Pernille Reimer Hansen, Hanne Frederiksen, and Christine Nellemann

Do Parabens Have the Ability to Interfere with Steroidogenesis?
ToxSci Advance Access published on July 22, 2008
Toxicol. Sci. 2008 106: 206-213; doi:10.1093/toxsci/kfn148 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Eija Salmela, Carin Sahlberg, Satu Alaluusua, and Pirjo-Liisa Lukinmaa

Tributyltin Impairs Dentin Mineralization and Enamel Formation in Cultured Mouse Embryonic Molar Teeth
ToxSci Advance Access published on July 29, 2008
Toxicol. Sci. 2008 106: 214-222; doi:10.1093/toxsci/kfn156 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Eugene Galdones and Barbara F. Hales

Retinoic Acid Receptor Gamma-Induced Misregulation of Chondrogenesis in the Murine Limb Bud In Vitro
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 223-232; doi:10.1093/toxsci/kfn169 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Annike I. Totlandsdal, Magne Refsnes, Tor Skomedal, Jan-Bjørn Osnes, Per E. Schwarze, and Marit Låg

Particle-Induced Cytokine Responses in Cardiac Cell Cultures—the Effect of Particles versus Soluble Mediators Released by Particle-Exposed Lung Cells
ToxSci Advance Access published on August 11, 2008
Toxicol. Sci. 2008 106: 233-241; doi:10.1093/toxsci/kfn162 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Changqing Su, Hui Cao, Shuping Tan, Yao Huang, Xiaoyuan Jia, Lixin Jiang, Kai Wang, Ying Chen, Ju Long, Xinyuan Liu, Mengchao Wu, Xiaobing Wu, and Qijun Qian

Toxicology Profiles of a Novel p53-Armed Replication-Competent Oncolytic Adenovirus in Rodents, Felids, and Nonhuman Primates
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 242-250; doi:10.1093/toxsci/kfn168 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Roy L. M. Dobson, Safa Motlagh, Mike Quijano, R. Thomas Cambron, Timothy R. Baker, Aletha M. Pullen, Brian T. Regg, Adrienne S. Bigalow-Kern, Thomas Vennard, Andrew Fix, Renate Reimschuessel, Gary Overmann, Yuching Shan, and George P. Daston

Identification and Characterization of Toxicity of Contaminants in Pet Food Leading to an Outbreak of Renal Toxicity in Cats and Dogs
ToxSci Advance Access published on August 9, 2008
Toxicol. Sci. 2008 106: 251-262; doi:10.1093/toxsci/kfn160 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Get checked abstract Janice S. Lee, William O. Ward, Douglas C. Wolf, James W. Allen, Camilla Mills, Michael J. DeVito, and J. Christopher Corton

Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats
ToxSci Advance Access published on July 24, 2008
Toxicol. Sci. 2008 106: 263-283; doi:10.1093/toxsci/kfn144 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Kyong-Son Min, Hidenori Ueda, Tetsuya Kihara, and Keiichi Tanaka

Increased Hepatic Accumulation of Ingested Cd is Associated with Upregulation of Several Intestinal Transporters in Mice Fed Diets Deficient in Essential Metals
ToxSci Advance Access published on July 22, 2008
Toxicol. Sci. 2008 106: 284-289; doi:10.1093/toxsci/kfn146 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jin-Hyung Lee, Atrayee Banerjee, Yoshi Ueno, and Shashi K. Ramaiah

Potential Relationship between Hepatobiliary Osteopontin and Peroxisome Proliferator–Activated Receptor Expression following Ethanol-Associated Hepatic Injury In Vivo and In Vitro
ToxSci Advance Access published on August 14, 2008
Toxicol. Sci. 2008 106: 290-299; doi:10.1093/toxsci/kfn165 [Abstract] [Full Text] [PDF] [Request Permissions]  

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