Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Gary H. Perdew

Ah Receptor Binding to its Cognate Response Element is Required for Dioxin-Mediated Toxicity
ToxSci Advance Access published on October 16, 2008
Toxicol. Sci. 2008 106: 301-303; doi:10.1093/toxsci/kfn220 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Diego Di Lorenzo, Gianpaolo Rando, Paolo Ciana, and Adriana Maggi

Molecular Imaging, an Innovative Methodology for Whole-Body Profiling of Endocrine Disrupter Action
ToxSci Advance Access published on September 15, 2008
Toxicol. Sci. 2008 106: 304-311; doi:10.1093/toxsci/kfn191 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Stephen W. Edwards and R. Julian Preston

Systems Biology and Mode of Action Based Risk Assessment
ToxSci Advance Access published on September 12, 2008
Toxicol. Sci. 2008 106: 312-318; doi:10.1093/toxsci/kfn190 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Jonathan M. Maher, Lauren M. Aleksunes, Matthew Z. Dieter, Yuji Tanaka, Jeffrey M. Peters, Jose E. Manautou, and Curtis D. Klaassen

Nrf2- and PPAR-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid
ToxSci Advance Access published on August 29, 2008
Toxicol. Sci. 2008 106: 319-328; doi:10.1093/toxsci/kfn177 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Tamara R. Knight, Supratim Choudhuri, and Curtis D. Klaassen

Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers
ToxSci Advance Access published on August 22, 2008
Toxicol. Sci. 2008 106: 329-338; doi:10.1093/toxsci/kfn179 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jihei Nishimura, Yasuaki Dewa, Toshiya Okamura, Meilan Jin, Yukie Saegusa, Masaomi Kawai, Takashi Umemura, Makoto Shibutani, and Kunitoshi Mitsumori

Role of Nrf2 and Oxidative stress on Fenofibrate-Induced Hepatocarcinogenesis in Rats
ToxSci Advance Access published on September 4, 2008
Toxicol. Sci. 2008 106: 339-349; doi:10.1093/toxsci/kfn174 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Shugo Suzuki, Lora L. Arnold, Takamasa Ohnishi, and Samuel M. Cohen

Effects of Inorganic Arsenic on the Rat and Mouse Urinary Bladder
ToxSci Advance Access published on August 26, 2008
Toxicol. Sci. 2008 106: 350-363; doi:10.1093/toxsci/kfn184 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jing-Hsien Chen, Hui-Hsuan Lin, Tai-An Chiang, Jeng-Dong Hsu, Hsieh-Hsun Ho, Yi-Chieh Lee, and Chau-Jong Wang

Gaseous Nitrogen Oxide Promotes Human Lung Cancer Cell Line A549 Migration, Invasion, and Metastasis via iNOS-Mediated MMP-2 Production
ToxSci Advance Access published on September 16, 2008
Toxicol. Sci. 2008 106: 364-375; doi:10.1093/toxsci/kfn195 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Hanne Frederiksen, Camilla Taxvig, Ulla Hass, Anne M. Vinggaard, and Christine Nellemann

Higher Levels of Ethyl Paraben and Butyl Paraben in Rat Amniotic Fluid than in Maternal Plasma after Subcutaneous Administration
ToxSci Advance Access published on August 18, 2008
Toxicol. Sci. 2008 106: 376-383; doi:10.1093/toxsci/kfn171 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Sara Calafato, Suresh Swain, Samantha Hughes, Peter Kille, and Stephen R. Stürzenbaum

Knock down of Caenorhabditis elegans cutc-1 Exacerbates the Sensitivity Toward High Levels of Copper
ToxSci Advance Access published on August 22, 2008
Toxicol. Sci. 2008 106: 384-391; doi:10.1093/toxsci/kfn180 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Valeria Dell'Ovo, Elena Bandi, Tamara Coslovich, Chiara Florio, Marina Sciancalepore, Giuliana Decorti, Silvio Sosa, Paola Lorenzon, Takeshi Yasumoto, and Aurelia Tubaro

In Vitro Effects of Yessotoxin on a Primary Culture of Rat Cardiomyocytes
ToxSci Advance Access published on September 17, 2008
Toxicol. Sci. 2008 106: 392-399; doi:10.1093/toxsci/kfn187 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Yannick Pereira, Gilles Lagniel, Emmanuel Godat, Peggy Baudouin-Cornu, Christophe Junot, and Jean Labarre

Chromate Causes Sulfur Starvation in Yeast
ToxSci Advance Access published on September 15, 2008
Toxicol. Sci. 2008 106: 400-412; doi:10.1093/toxsci/kfn193 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Chang Seok Park, Ohn Soon Kim, Sang-Moon Yun, Sangmee A. Jo, Inho Jo, and Young Ho Koh

Presenilin 1/-Secretase Is Associated with Cadmium-Induced E-Cadherin Cleavage and COX-2 Gene Expression in T47D Breast Cancer Cells
ToxSci Advance Access published on September 12, 2008
Toxicol. Sci. 2008 106: 413-422; doi:10.1093/toxsci/kfn197 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Josje H. E. Arts, Wim H. de Jong, Jos J. van Triel, Marcel A. Schijf, Arja de Klerk, Henk van Loveren, and C. Frieke Kuper

The Respiratory Local Lymph Node Assay as a Tool to Study Respiratory Sensitizers
ToxSci Advance Access published on September 23, 2008
Toxicol. Sci. 2008 106: 423-434; doi:10.1093/toxsci/kfn199 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Christal C. Bowman and MaryJane K. Selgrade

Failure to Induce Oral Tolerance in Mice Is Predictive of Dietary Allergenic Potency among Foods with Sensitizing Capacity
ToxSci Advance Access published on September 19, 2008
Toxicol. Sci. 2008 106: 435-443; doi:10.1093/toxsci/kfn200 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract M. Henjakovic, C. Martin, H. G. Hoymann, K. Sewald, A. R. Ressmeyer, C. Dassow, G. Pohlmann, N. Krug, S. Uhlig, and A. Braun

Ex Vivo Lung Function Measurements in Precision-Cut Lung Slices (PCLS) from Chemical Allergen–Sensitized Mice Represent a Suitable Alternative to In Vivo Studies
ToxSci Advance Access published on September 4, 2008
Toxicol. Sci. 2008 106: 444-453; doi:10.1093/toxsci/kfn178 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ya-Jean Wang, Bing-Shuo Chen, Ming-Wei Lin, An-An Lin, Hsung Peng, Ruey J. Sung, and Sheng-Nan Wu

Time-Dependent Block of Ultrarapid-Delayed Rectifier K⁺ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2 Myoblasts and in Neonatal Rat Ventricular Myocytes
ToxSci Advance Access published on September 8, 2008
Toxicol. Sci. 2008 106: 454-463; doi:10.1093/toxsci/kfn189 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Andreas Natsch and Hans Gfeller

LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential
ToxSci Advance Access published on September 12, 2008
Toxicol. Sci. 2008 106: 464-478; doi:10.1093/toxsci/kfn194 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Doug Crump, Suzanne Chiu, Caroline Egloff, and Sean W. Kennedy

Effects of Hexabromocyclododecane and Polybrominated Diphenyl Ethers on mRNA Expression in Chicken (Gallus domesticus) Hepatocytes
ToxSci Advance Access published on September 12, 2008
Toxicol. Sci. 2008 106: 479-487; doi:10.1093/toxsci/kfn196 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Chad M. Vezina, Sarah Hicks Allgeier, Robert W. Moore, Tien-Min Lin, Jeffrey C. Bemis, Heather A. Hardin, Thomas A. Gasiewicz, and Richard E. Peterson

Dioxin Causes Ventral Prostate Agenesis by Disrupting Dorsoventral Patterning in Developing Mouse Prostate
ToxSci Advance Access published on September 8, 2008
Toxicol. Sci. 2008 106: 488-496; doi:10.1093/toxsci/kfn183 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Rachel Rogers, Gregory Ouellet, Caitlin Brown, Ben Moyer, Teresa Rasoulpour, and Mary Hixon

Cross-talk between the Akt and NF-B Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis
ToxSci Advance Access published on August 28, 2008
Toxicol. Sci. 2008 106: 497-508; doi:10.1093/toxsci/kfn186 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Shawn Monique Castro, Deepthi Kolli, Antonieta Guerrero-Plata, Roberto P. Garofalo, and Antonella Casola

Cigarette Smoke Condensate Enhances Respiratory Syncytial Virus–Induced Chemokine Release by Modulating NF-kappa B and Interferon Regulatory Factor Activation
ToxSci Advance Access published on August 22, 2008
Toxicol. Sci. 2008 106: 509-518; doi:10.1093/toxsci/kfn175 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Ted Simon, Christopher R. Kirman, Lesa L. Aylward, Robert A. Budinsky, J. Craig Rowlands, and Tom F. Long

Estimates of Cancer Potency of 2,3,4,7,8-Pentachlorodibenzofuran Using Both Nonlinear and Linear Approaches
ToxSci Advance Access published on August 22, 2008
Toxicol. Sci. 2008 106: 519-537; doi:10.1093/toxsci/kfn176 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Makoto Miyamoto, Mariko Yanai, Shingo Ookubo, Naoko Awasaki, Kenji Takami, and Ryoetsu Imai

Detection of Cell-Free, Liver-Specific mRNAs in Peripheral Blood from Rats with Hepatotoxicity: A Potential Toxicological Biomarker for Safety Evaluation
ToxSci Advance Access published on September 8, 2008
Toxicol. Sci. 2008 106: 538-545; doi:10.1093/toxsci/kfn188 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Cang-Bao Xu, Jian-Pu Zheng, Wei Zhang, Yaping Zhang, and Lars Edvinsson

Lipid-Soluble Smoke Particles Upregulate Vascular Smooth Muscle ET_B Receptors via Activation of Mitogen-Activating Protein Kinases and NF-kappaB Pathways
ToxSci Advance Access published on August 20, 2008
Toxicol. Sci. 2008 106: 546-555; doi:10.1093/toxsci/kfn173 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Mary B. Dail, L. Allen Shack, Janice E. Chambers, and Shane C. Burgess

Global Liver Proteomics of Rats Exposed for 5 Days to Phenobarbital Identifies Changes Associated with Cancer and with CYP Metabolism
ToxSci Advance Access published on September 16, 2008
Toxicol. Sci. 2008 106: 556-569; doi:10.1093/toxsci/kfn198 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

LETTERS TO THE EDITOR

James Huff

Long-term Cancer Bioassays of Ascorbic Acid
ToxSci Advance Access published on August 28, 2008
Toxicol. Sci. 2008 106: 570-571; doi:10.1093/toxsci/kfn185 [Extract] [Full Text] [PDF] [Request Permissions]  

David W. Roberts and Grace Y. Patlewicz

Nonanimal Alternatives for Skin Sensitization: Letter to the Editor
ToxSci Advance Access published on August 28, 2008
Toxicol. Sci. 2008 106: 572-574; doi:10.1093/toxsci/kfn181 [Extract] [Full Text] [PDF] [Request Permissions]  

David Basketter

Nonanimal Alternatives for Skin Sensitization: Response
ToxSci Advance Access published on September 16, 2008
Toxicol. Sci. 2008 106: 575; doi:10.1093/toxsci/kfn182 [Extract] [Full Text] [PDF] [Request Permissions]  

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