Toxicological Sciences

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Robert T. Taylor, Feng Wang, Erin L. Hsu, and Oliver Hankinson

Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells
ToxSci Advance Access published on October 8, 2008
Toxicol. Sci. 2009 107: 1-8; doi:10.1093/toxsci/kfn217 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Pavlína Simecková, Jan Vondrácek, Zdenek Andrysík, Jirina Zatloukalová, Pavel Krcmár, Alois Kozubík, and Miroslav Machala

The 2,2',4,4',5,5'-Hexachlorobiphenyl–Enhanced Degradation of Connexin 43 Involves Both Proteasomal and Lysosomal Activities
ToxSci Advance Access published on October 1, 2008
Toxicol. Sci. 2009 107: 9-18; doi:10.1093/toxsci/kfn202 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Grace E. Kissling, David E. Malarkey, Molly K. Vallant, Jerry D. Johnson, Milton R. Hejtmancik, Ronald A. Herbert, and Gary A. Boorman

Evaluation of Dichloroacetic Acid for Carcinogenicity in Genetically Modified Tg.AC Hemizygous and p53 Haploinsufficient Mice
ToxSci Advance Access published on October 30, 2008
Toxicol. Sci. 2009 107: 19-26; doi:10.1093/toxsci/kfn228 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract David T. Szabo, Vicki M. Richardson, David G. Ross, Janet J. Diliberto, Prasada R. S. Kodavanti, and Linda S. Birnbaum

Effects of Perinatal PBDE Exposure on Hepatic Phase I, Phase II, Phase III, and Deiodinase 1 Gene Expression Involved in Thyroid Hormone Metabolism in Male Rat Pups
ToxSci Advance Access published on October 31, 2008
Toxicol. Sci. 2009 107: 27-39; doi:10.1093/toxsci/kfn230 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Jorge M. Naciff, Zubin S. Khambatta, Ryan G. Thomason, Gregory J. Carr, Jay P. Tiesman, David W. Singleton, Sohaib A. Khan, and George P. Daston

The Genomic Response of a Human Uterine Endometrial Adenocarcinoma Cell Line to 17-Ethynyl Estradiol
ToxSci Advance Access published on October 20, 2008
Toxicol. Sci. 2009 107: 40-55; doi:10.1093/toxsci/kfn219 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper, and Tammy E. Stoker

The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats
ToxSci Advance Access published on October 21, 2008
Toxicol. Sci. 2009 107: 56-64; doi:10.1093/toxsci/kfn225 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Kathi A. Lefebvre, Susan C. Tilton, Theo K. Bammler, Richard P. Beyer, Sengkeo Srinouanprachan, Patricia L. Stapleton, Federico M. Farin, and Evan P. Gallagher

Gene Expression Profiles in Zebrafish Brain after Acute Exposure to Domoic Acid at Symptomatic and Asymptomatic Doses
ToxSci Advance Access published on October 20, 2008
Toxicol. Sci. 2009 107: 65-77; doi:10.1093/toxsci/kfn207 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Paul D. Siegel, Adam Fedorowicz, Leon Butterworth, Brandon Law, Stacey E. Anderson, James Snyder, and Don Beezhold

Physical-Chemical and Solvent Considerations in Evaluating the Influence of Carbon Chain Length on the Skin Sensitization Activity of 1-Bromoalkanes
ToxSci Advance Access published on October 20, 2008
Toxicol. Sci. 2009 107: 78-84; doi:10.1093/toxsci/kfn212 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Colin M. North, Byung-Sam Kim, Neil Snyder, Robert B. Crawford, Michael P. Holsapple, and Norbert E. Kaminski

TCDD-Mediated Suppression of the In Vitro Anti-Sheep Erythrocyte IgM Antibody Forming Cell Response is Reversed by Interferon-Gamma
ToxSci Advance Access published on October 22, 2008
Toxicol. Sci. 2009 107: 85-92; doi:10.1093/toxsci/kfn223 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract William S. Baldwin and Jonathan A. Roling

A Concentration Addition Model for the Activation of the Constitutive Androstane Receptor by Xenobiotic Mixtures
ToxSci Advance Access published on October 1, 2008
Toxicol. Sci. 2009 107: 93-105; doi:10.1093/toxsci/kfn206 [Abstract] [FREE Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Andreas Natsch, Roger Emter, and Graham Ellis

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing
ToxSci Advance Access published on October 1, 2008
Toxicol. Sci. 2009 107: 106-121; doi:10.1093/toxsci/kfn204 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract John Sanseverino, Melanie L. Eldridge, Alice C. Layton, James P. Easter, Jason Yarbrough, Terry Wayne Schultz, and Gary S. Sayler

Screening of Potentially Hormonally Active Chemicals Using Bioluminescent Yeast Bioreporters
ToxSci Advance Access published on November 7, 2008
Toxicol. Sci. 2009 107: 122-134; doi:10.1093/toxsci/kfn229 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Ling Wang, Haiyan Jiang, Zhaobao Yin, Michael Aschner, and Jiyang Cai

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes
ToxSci Advance Access published on September 23, 2008
Toxicol. Sci. 2009 107: 135-143; doi:10.1093/toxsci/kfn201 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Bin Li, Lawrence M. Schopfer, Hasmik Grigoryan, Charles M. Thompson, Steven H. Hinrichs, Patrick Masson, and Oksana Lockridge

Tyrosines of Human and Mouse Transferrin Covalently Labeled by Organophosphorus Agents: A New Motif for Binding to Proteins that Have No Active Site Serine
ToxSci Advance Access published on October 16, 2008
Toxicol. Sci. 2009 107: 144-155; doi:10.1093/toxsci/kfn211 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Fang Zhao, Tongjian Cai, Mingchao Liu, Gang Zheng, Wenjing Luo, and Jingyuan Chen

Manganese Induces Dopaminergic Neurodegeneration via Microglial Activation in a Rat Model of Manganism
ToxSci Advance Access published on October 4, 2008
Toxicol. Sci. 2009 107: 156-164; doi:10.1093/toxsci/kfn213 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ping Gao, Ping He, AiGuo Wang, Tao Xia, BaYi Xu, ZhiXia Xu, Qiang Niu, LiJuan Guo, and XueMin Chen

Influence of PCB153 on Oxidative DNA Damage and DNA Repair–Related Gene Expression Induced by PBDE-47 in Human Neuroblastoma Cells In Vitro
ToxSci Advance Access published on October 22, 2008
Toxicol. Sci. 2009 107: 165-170; doi:10.1093/toxsci/kfn224 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Thomas Jursa and Donald R. Smith

Ceruloplasmin Alters the Tissue Disposition and Neurotoxicity of Manganese, but not its Loading onto Transferrin
ToxSci Advance Access published on November 12, 2008
Toxicol. Sci. 2009 107: 182-193; doi:10.1093/toxsci/kfn231 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Francesco Marchetti, Jack Bishop, Xiu Lowe, and Andrew J. Wyrobek

Chromosomal Mosaicism in Mouse Two-Cell Embryos after Paternal Exposure to Acrylamide
ToxSci Advance Access published on October 16, 2008
Toxicol. Sci. 2009 107: 194-205; doi:10.1093/toxsci/kfn209 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Joshua F. Robinson, Xiaozhong Yu, Sungwoo Hong, William C. Griffith, Richard Beyer, Euvin Kim, and Elaine M. Faustman

Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation
ToxSci Advance Access published on October 29, 2008
Toxicol. Sci. 2009 107: 206-219; doi:10.1093/toxsci/kfn221 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Corneliu N. Craciunescu, Mihai D. Niculescu, Zhong Guo, Amy R. Johnson, Leslie Fischer, and Steven H. Zeisel

Dose Response Effects of Dermally applied Diethanolamine on Neurogenesis in Fetal Mouse Hippocampus and Potential Exposure of Humans
ToxSci Advance Access published on October 23, 2008
Toxicol. Sci. 2009 107: 220-226; doi:10.1093/toxsci/kfn227 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Kelly A. Brant and James P. Fabisiak

Nickel and the Microbial Toxin, MALP-2, Stimulate Proangiogenic Mediators from Human Lung Fibroblasts via a HIF-1 and COX-2–Mediated Pathway
ToxSci Advance Access published on October 1, 2008
Toxicol. Sci. 2009 107: 227-237; doi:10.1093/toxsci/kfn208 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Sheetal A. Thakur, Raymond Hamilton, Jr, Timo Pikkarainen, and Andrij Holian

Differential Binding of Inorganic Particles to MARCO
ToxSci Advance Access published on October 4, 2008
Toxicol. Sci. 2009 107: 238-246; doi:10.1093/toxsci/kfn210 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Errol Zeiger, Leslie Recio, Timothy R. Fennell, Joseph K. Haseman, Rodney W. Snyder, and Marvin Friedman

Investigation of the Low-Dose Response in the In Vivo Induction of Micronuclei and Adducts by Acrylamide
ToxSci Advance Access published on October 17, 2008
Toxicol. Sci. 2009 107: 247-257; doi:10.1093/toxsci/kfn214 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Patrick J. Shaw, Amy C. Ditewig, Jeffrey F. Waring, Michael J. Liguori, Eric A. Blomme, Patricia E. Ganey, and Robert A. Roth

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury
ToxSci Advance Access published on October 16, 2008
Toxicol. Sci. 2009 107: 270-280; doi:10.1093/toxsci/kfn205 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Zhen Li, Fred A. Wright, and Joyce Royland

Age-Dependent Variability in Gene Expression in Male Fischer 344 Rat Retina
ToxSci Advance Access published on October 20, 2008
Toxicol. Sci. 2009 107: 281-292; doi:10.1093/toxsci/kfn215 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Felicia A. Jefferson, Gong H. Xiao, and David W. Hein

4-Aminobiphenyl Downregulation of NAT2 Acetylator Genotype–Dependent N- and O-acetylation of Aromatic and Heterocyclic Amine Carcinogens in Primary Mammary Epithelial Cell Cultures from Rapid and Slow Acetylator Rats
ToxSci Advance Access published on October 8, 2008
Toxicol. Sci. 2009 107: 293-297; doi:10.1093/toxsci/kfn216 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sevil Korkmaz, Véronique Maupoil, Cécile Sobry, Chloé Brunet, Stephan Chevalier, and Jean-Louis Freslon

An Increased Regional Blood Flow Precedes Mesenteric Inflammation in Rats Treated by a Phosphodiesterase 4 Inhibitor
ToxSci Advance Access published on October 15, 2008
Toxicol. Sci. 2009 107: 298-305; doi:10.1093/toxsci/kfn218 [Abstract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2009 107: 306; doi:10.1093/toxsci/kfn238 [Extract] [Full Text] [PDF] [Request Permissions]  

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