Toxicological Sciences

EDITORIAL

Michael P. Holsapple, Cynthia A. Afshari, and Lois D. Lehman-McKeeman

Forum Series: The "Vision" for Toxicity Testing in the 21st Century: Promises and Conundrums
ToxSci Advance Access published on December 9, 2008
Toxicol. Sci. 2009 107: 307-308; doi:10.1093/toxsci/kfn258 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

TOXICOLOGICAL HIGHLIGHT

David J. Thomas

Unraveling Arsenic—Glutathione Connections
ToxSci Advance Access published on December 12, 2008
Toxicol. Sci. 2009 107: 309-311; doi:10.1093/toxsci/kfn257 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract J. Christopher States, Sanjay Srivastava, Yu Chen, and Aaron Barchowsky

Arsenic and Cardiovascular Disease
ToxSci Advance Access published on November 17, 2008
Toxicol. Sci. 2009 107: 312-323; doi:10.1093/toxsci/kfn236 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES, PART I

Get checked abstract Melvin E. Andersen and Daniel Krewski

Toxicity Testing in the 21st Century: Bringing the Vision to Life
ToxSci Advance Access published on December 12, 2008
Toxicol. Sci. 2009 107: 324-330; doi:10.1093/toxsci/kfn255 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Inchio Lou, John F. Wambaugh, Christopher Lau, Roger G. Hanson, Andrew B. Lindstrom, Mark J. Strynar, R. Dan Zehr, R. Woodrow Setzer, and Hugh A. Barton

Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice
ToxSci Advance Access published on November 12, 2008
Toxicol. Sci. 2009 107: 331-341; doi:10.1093/toxsci/kfn234 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Mo-Tao Zhu, Wei-Yue Feng, Yun Wang, Bing Wang, Meng Wang, Hong Ouyang, Yu-Liang Zhao, and Zhi-Fang Chai

Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment
ToxSci Advance Access published on November 20, 2008
Toxicol. Sci. 2009 107: 342-351; doi:10.1093/toxsci/kfn245 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Shakil A. Saghir, David L. Rick, E. L. McClymont, Fagen Zhang, Michael J. Bartels, and James S. Bus

Mechanism of Ethylbenzene-Induced Mouse-Specific Lung Tumor: Metabolism of Ethylbenzene by Rat, Mouse, and Human Liver and Lung Microsomes
ToxSci Advance Access published on December 15, 2008
Toxicol. Sci. 2009 107: 352-366; doi:10.1093/toxsci/kfn244 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Xuefeng Ren, Sophia Lim, Martyn T. Smith, and Luoping Zhang

Werner Syndrome Protein, WRN, Protects Cells from DNA Damage Induced by the Benzene Metabolite Hydroquinone
ToxSci Advance Access published on December 8, 2008
Toxicol. Sci. 2009 107: 367-375; doi:10.1093/toxsci/kfn254 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Jui-Pin Wu, Louis W. Chang, Hsien-Tsung Yao, Han Chang, Hui-Ti Tsai, Ming-Hsien Tsai, Teng-Kuang Yeh, and Pinpin Lin

Involvement of Oxidative Stress and Activation of Aryl Hydrocarbon Receptor in Elevation of CYP1A1 Expression and Activity in Lung Cells and Tissues by Arsenic: An In Vitro and In Vivo Study
ToxSci Advance Access published on November 25, 2008
Toxicol. Sci. 2009 107: 385-393; doi:10.1093/toxsci/kfn239 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Monika Kaczmarek, Raul E. Cachau, Igor A. Topol, Kazimierz S. Kasprzak, Andy Ghio, and Konstantin Salnikow

Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1 Protein
ToxSci Advance Access published on December 13, 2008
Toxicol. Sci. 2009 107: 394-403; doi:10.1093/toxsci/kfn251 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Robert J. Griffitt, Kelly Hyndman, Nancy D. Denslow, and Davis S. Barber

Comparison of Molecular and Histological Changes in Zebrafish Gills Exposed to Metallic Nanoparticles
ToxSci Advance Access published on December 10, 2008
Toxicol. Sci. 2009 107: 404-415; doi:10.1093/toxsci/kfn256 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract Jorge G. Muñiz Ortiz, Robert Opoka, Daniel Kane, and Iain L. Cartwright

Investigating Arsenic Susceptibility from a Genetic Perspective in Drosophila Reveals a Key Role for Glutathione Synthetase
ToxSci Advance Access published on September 8, 2008
Toxicol. Sci. 2009 107: 416-426; doi:10.1093/toxsci/kfn192 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Darrell R. Boverhof, B. Bhaskar Gollapudi, Jon A. Hotchkiss, Mandy Osterloh-Quiroz, and Michael R. Woolhiser

Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA)
ToxSci Advance Access published on November 28, 2008
Toxicol. Sci. 2009 107: 427-439; doi:10.1093/toxsci/kfn247 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Francisco Ucán-Marín, Augustine Arukwe, Anne Mortensen, Geir W. Gabrielsen, Glen A. Fox, and Robert J. Letcher

Recombinant Transthyretin Purification and Competitive Binding with Organohalogen Compounds in Two Gull Species (Larus argentatus and Larus hyperboreus)
ToxSci Advance Access published on November 25, 2008
Toxicol. Sci. 2009 107: 440-450; doi:10.1093/toxsci/kfn240 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Nadège Ade, Fanny Leon, Marc Pallardy, Jean-Luc Peiffer, Saadia Kerdine-Romer, Marie-Hélène Tissier, Pierre-Antoine Bonnet, Isabelle Fabre, and Jean-Claude Ourlin

HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway
ToxSci Advance Access published on November 25, 2008
Toxicol. Sci. 2009 107: 451-460; doi:10.1093/toxsci/kfn243 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Pere Boadas-Vaello, Eric Jover, Sandra Saldaña-Ruíz, Carla Soler-Martín, Christian Chabbert, Josep M. Bayona, and Jordi Llorens

Allylnitrile Metabolism by CYP2E1 and Other CYPs Leads to Distinct Lethal and Vestibulotoxic Effects in the Mouse
ToxSci Advance Access published on November 6, 2008
Toxicol. Sci. 2009 107: 461-472; doi:10.1093/toxsci/kfn233 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Katy Maguin, Pierre Campo, and Cécile Parietti-Winkler

Toluene Can Perturb the Neuronal Voltage-Dependent Ca²⁺ Channels Involved in the Middle-Ear Reflex
ToxSci Advance Access published on November 24, 2008
Toxicol. Sci. 2009 107: 473-481; doi:10.1093/toxsci/kfn242 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Desire Tshala-Katumbay, Victor Monterroso, Robert Kayton, Michael Lasarev, Mohammad Sabri, and Peter Spencer

Probing Mechanisms of Axonopathy. Part II: Protein Targets of 2,5-Hexanedione, the Neurotoxic Metabolite of the Aliphatic Solvent n-Hexane
ToxSci Advance Access published on November 25, 2008
Toxicol. Sci. 2009 107: 482-489; doi:10.1093/toxsci/kfn241 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Milou M. L. Dingemans, Harm J. Heusinkveld, Aart de Groot, Åke Bergman, Martin van den Berg, and Remco H. S. Westerink

Hexabromocyclododecane Inhibits Depolarization-Induced Increase in Intracellular Calcium Levels and Neurotransmitter Release in PC12 Cells
ToxSci Advance Access published on December 4, 2008
Toxicol. Sci. 2009 107: 490-497; doi:10.1093/toxsci/kfn249 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Kevin M. Kransler, Barbara P. McGarrigle, Daniel D. Swartz, and James R. Olson

Lung Development in the Holtzman Rat is Adversely Affected by Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
ToxSci Advance Access published on November 6, 2008
Toxicol. Sci. 2009 107: 498-511; doi:10.1093/toxsci/kfn235 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Tao Jiang, David R. Bell, Sally Clode, Ming Qi Fan, Alwyn Fernandes, Paul M. D. Foster, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Lang Tran, and Shaun White

A Truncation in the Aryl Hydrocarbon Receptor of the CRL:WI(Han) Rat Does Not Affect the Developmental Toxicity of TCDD
ToxSci Advance Access published on December 4, 2008
Toxicol. Sci. 2009 107: 512-521; doi:10.1093/toxsci/kfn252 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Tina Stevens, Seung-Hyun Cho, William P. Linak, and M. Ian Gilmour

Differential Potentiation of Allergic Lung Disease in Mice Exposed to Chemically Distinct Diesel Samples
ToxSci Advance Access published on December 12, 2008
Toxicol. Sci. 2009 107: 522-534; doi:10.1093/toxsci/kfn248 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Elizabeth M. Vancza, Karen Galdanes, Al Gunnison, Gary Hatch, and Terry Gordon

Age, Strain, and Gender as Factors for Increased Sensitivity of the Mouse Lung to Inhaled Ozone
ToxSci Advance Access published on December 9, 2008
Toxicol. Sci. 2009 107: 535-543; doi:10.1093/toxsci/kfn253 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Anne S. Kienhuis, Marcel C. G. van de Poll, Heleen Wortelboer, Marcel van Herwijnen, Ralph Gottschalk, Cornelis H. C. Dejong, André Boorsma, Richard S. Paules, Jos C. S. Kleinjans, Rob H. Stierum, and Joost H. M. van Delft

Parallelogram Approach Using Rat-Human In Vitro and Rat In Vivo Toxicogenomics Predicts Acetaminophen-induced Hepatotoxicity in Humans
ToxSci Advance Access published on November 12, 2008
Toxicol. Sci. 2009 107: 544-552; doi:10.1093/toxsci/kfn237 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Katrina M. Waters, Lisa M. Masiello, Richard C. Zangar, Barbara J. Tarasevich, Norman J. Karin, Ryan D. Quesenberry, Somnath Bandyopadhyay, Justin G. Teeguarden, Joel G. Pounds, and Brian D. Thrall

Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes
ToxSci Advance Access published on December 10, 2008
Toxicol. Sci. 2009 107: 553-569; doi:10.1093/toxsci/kfn250 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

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