Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Jeffry D. Schroeter

The Use of Nasal Dosimetry Models in the Risk Assessment of Inhaled Gases
ToxSci Advance Access published on January 23, 2009
Toxicol. Sci. 2009 108: 1-3; doi:10.1093/toxsci/kfp013 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Peter G. Wells, Gordon P. McCallum, Connie S. Chen, Jeffrey T. Henderson, Crystal J. J. Lee, Julia Perstin, Thomas J. Preston, Michael J. Wiley, and Andrea W. Wong

Oxidative Stress in Developmental Origins of Disease: Teratogenesis, Neurodevelopmental Deficits, and Cancer
ToxSci Advance Access published on January 6, 2009
Toxicol. Sci. 2009 108: 4-18; doi:10.1093/toxsci/kfn263 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES: THE 'VISION' FOR TOXICITY TESTING IN THE 21ST CENTURY

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Andy Nong, Michael D. Taylor, Harvey J. Clewell, III, David C. Dorman, and Melvin E. Andersen

Manganese Tissue Dosimetry in Rats and Monkeys: Accounting for Dietary and Inhaled Mn with Physiologically based Pharmacokinetic Modeling
ToxSci Advance Access published on December 19, 2008
Toxicol. Sci. 2009 108: 22-34; doi:10.1093/toxsci/kfn264 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Scott A. Reisman, Ronnie L. Yeager, Masayuki Yamamoto, and Curtis D. Klaassen

Increased Nrf2 Activation in Livers from Keap1-Knockdown Mice Increases Expression of Cytoprotective Genes that Detoxify Electrophiles more than those that Detoxify Reactive Oxygen Species
ToxSci Advance Access published on January 6, 2009
Toxicol. Sci. 2009 108: 35-47; doi:10.1093/toxsci/kfn267 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Lakshmi Gopinathan, Daniel B. Hannon, Jeffrey M. Peters, and John P. Vanden Heuvel

Regulation of Peroxisome Proliferator–Activated Receptor- by MDM2
ToxSci Advance Access published on December 22, 2008
Toxicol. Sci. 2009 108: 48-58; doi:10.1093/toxsci/kfn260 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Tomoya Yamada, Satoshi Uwagawa, Yasuyoshi Okuno, Samuel M. Cohen, and Hideo Kaneko

Case Study: An Evaluation of the Human Relevance of the Synthetic Pyrethroid Metofluthrin-Induced Liver Tumors in Rats Based on Mode of Action
ToxSci Advance Access published on January 27, 2009
Toxicol. Sci. 2009 108: 59-68; doi:10.1093/toxsci/kfp007 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Yoshihito Deguchi, Tomoya Yamada, Yukihiro Hirose, Hirohisa Nagahori, Masahiko Kushida, Kayo Sumida, Tokuo Sukata, Yoshitaka Tomigahara, Kazuhiko Nishioka, Satoshi Uwagawa, Satoshi Kawamura, and Yasuyoshi Okuno

Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation
ToxSci Advance Access published on January 27, 2009
Toxicol. Sci. 2009 108: 69-80; doi:10.1093/toxsci/kfp006 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Jun Chen, Ping Xie, Li Li, and Jun Xu

First Identification of the Hepatotoxic Microcystins in the Serum of a Chronically Exposed Human Population Together with Indication of Hepatocellular Damage
ToxSci Advance Access published on January 16, 2009
Toxicol. Sci. 2009 108: 81-89; doi:10.1093/toxsci/kfp009 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

IMMUNOTOXICOLOGY

Get checked abstract Gerardo Ramos, Alberto Y. Limon-Flores, and Stephen E. Ullrich

JP-8 Induces Immune Suppression via a Reactive Oxygen Species NF-β–Dependent Mechanism
ToxSci Advance Access published on December 18, 2008
Toxicol. Sci. 2009 108: 100-109; doi:10.1093/toxsci/kfn262 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Deborah E. Keil, W. David McGuinn, Andrew C. Dudley, Jackie G. EuDaly, Gary S. Gilkeson, and Margie M. Peden-Adams

N,N,-Diethyl-m-Toluamide (DEET) Suppresses Humoral Immunological Function in B6C3F1 Mice
ToxSci Advance Access published on January 13, 2009
Toxicol. Sci. 2009 108: 110-123; doi:10.1093/toxsci/kfp001 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VIRTO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Sheng-Hao Wang, Yung-Luen Shih, Tai-Chin Kuo, Wun-Chang Ko, and Chwen-Ming Shih

Cadmium Toxicity toward Autophagy through ROS-Activated GSK-3β in Mesangial Cells
ToxSci Advance Access published on January 6, 2009
Toxicol. Sci. 2009 108: 124-131; doi:10.1093/toxsci/kfn266 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Måns Jergil, Kim Kultima, Anne-Lee Gustafson, Lennart Dencker, and Michael Stigson

Valproic Acid–Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects
ToxSci Advance Access published on January 8, 2009
Toxicol. Sci. 2009 108: 132-148; doi:10.1093/toxsci/kfp002 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Xiaoju Zou, Tucker A. Patterson, Natalya Sadovova, Nathan C. Twaddle, Daniel R. Doerge, Xuan Zhang, Xin Fu, Joseph P. Hanig, Merle G. Paule, William Slikker, and Cheng Wang

Potential Neurotoxicity of Ketamine in the Developing Rat Brain
ToxSci Advance Access published on January 6, 2009
Toxicol. Sci. 2009 108: 149-158; doi:10.1093/toxsci/kfn270 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract William K. Boyes, Mark Bercegeay, Wendy M. Oshiro, Q. Todd Krantz, Elaina M. Kenyon, Philip J. Bushnell, and Vernon A. Benignus

Acute Perchloroethylene Exposure Alters Rat Visual-Evoked Potentials in Relation to Brain Concentrations
ToxSci Advance Access published on December 19, 2008
Toxicol. Sci. 2009 108: 159-172; doi:10.1093/toxsci/kfn265 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract John B. Morris and Ann F. Hubbs

Inhalation Dosimetry of Diacetyl and Butyric Acid, Two Components of Butter Flavoring Vapors
ToxSci Advance Access published on October 21, 2008
Toxicol. Sci. 2009 108: 173-183; doi:10.1093/toxsci/kfn222 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Wei Zou, Sachin S. Devi, Erica Sparkenbaugh, Husam S. Younis, Robert A. Roth, and Patricia E. Ganey

Hepatotoxic Interaction of Sulindac with Lipopolysaccharide: Role of the Hemostatic System
ToxSci Advance Access published on December 12, 2008
Toxicol. Sci. 2009 108: 184-193; doi:10.1093/toxsci/kfn259 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Neera Tewari-Singh, Sumeet Rana, Mallikarjuna Gu, Arttatrana Pal, David J. Orlicky, Carl W. White, and Rajesh Agarwal

Inflammatory Biomarkers of Sulfur Mustard Analog 2-Chloroethyl Ethyl Sulfide–Induced Skin Injury in SKH-1 Hairless Mice
ToxSci Advance Access published on December 15, 2008
Toxicol. Sci. 2009 108: 194-206; doi:10.1093/toxsci/kfn261 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Brooke L. Heidenfelder, David M. Reif, Jack R. Harkema, Elaine A. Cohen Hubal, Edward E. Hudgens, Lori A. Bramble, James G. Wagner, Masako Morishita, Gerald J. Keeler, Stephen W. Edwards, and Jane E. Gallagher

Comparative Microarray Analysis and Pulmonary Changes in Brown Norway Rats Exposed to Ovalbumin and Concentrated Air Particulates
ToxSci Advance Access published on January 27, 2009
Toxicol. Sci. 2009 108: 207-221; doi:10.1093/toxsci/kfp005 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2009 108: 222; doi:10.1093/toxsci/kfn271 [Extract] [Full Text] [PDF] [Request Permissions]  

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