Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Saber M. Hussain and John J. Schlager

Safety Evaluation of Silver Nanoparticles: Inhalation Model for Chronic Exposure
ToxSci Advance Access published on February 23, 2009
Toxicol. Sci. 2009 108: 223-224; doi:10.1093/toxsci/kfp032 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Yazen Alnouti

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification
ToxSci Advance Access published on January 8, 2009
Toxicol. Sci. 2009 108: 225-246; doi:10.1093/toxsci/kfn268 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Yuji Tanaka, Lauren M. Aleksunes, Yue Julia Cui, and Curtis D. Klaassen

ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling
ToxSci Advance Access published on January 29, 2009
Toxicol. Sci. 2009 108: 247-257; doi:10.1093/toxsci/kfp020 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Ezra R. Lowe, Torka S. Poet, David L. Rick, M. Sue Marty, Joel L. Mattsson, Charles Timchalk, and Michael J. Bartels

The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data
ToxSci Advance Access published on February 17, 2009
Toxicol. Sci. 2009 108: 258-272; doi:10.1093/toxsci/kfp034 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jennifer M. Phillips and Jay I. Goodman

Multiple Genes Exhibit Phenobarbital-Induced Constitutive Active/Androstane Receptor–Mediated DNA Methylation Changes during Liver Tumorigenesis and in Liver Tumors
ToxSci Advance Access published on February 20, 2009
Toxicol. Sci. 2009 108: 273-289; doi:10.1093/toxsci/kfp031 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Dennie G. A. J. Hebels, Danyel G. J. Jennen, Jos C. S. Kleinjans, and Theo M. C. M. de Kok

Molecular Signatures of N-nitroso Compounds in Caco-2 Cells: Implications for Colon Carcinogenesis
ToxSci Advance Access published on February 16, 2009
Toxicol. Sci. 2009 108: 290-300; doi:10.1093/toxsci/kfp035 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Florencia Chiappini, Laura Alvarez, Victoria Lux-Lantos, Andrea S. Randi, and Diana L. Kleiman de Pisarev

Hexachlorobenzene Triggers Apoptosis in Rat Thyroid Follicular Cells
ToxSci Advance Access published on January 30, 2009
Toxicol. Sci. 2009 108: 301-310; doi:10.1093/toxsci/kfp016 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract De Angelis Simona, Tassinari Roberta, Maranghi Francesca, Eusepi Agostino, Di Virgilio Antonio, Chiarotti Flavia, Ricceri Laura, Venerosi Pesciolini Aldina, Gilardi Enzo, Moracci Gabriele, Calamandrei Gemma, Olivieri Antonella, and Mantovani Alberto

Developmental Exposure to Chlorpyrifos Induces Alterations in Thyroid and Thyroid Hormone Levels Without Other Toxicity Signs in CD-1 Mice
ToxSci Advance Access published on February 3, 2009
Toxicol. Sci. 2009 108: 311-319; doi:10.1093/toxsci/kfp017 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Beatrice A. Nyagode, Margaret O. James, and Kevin M. Kleinow

Influence of Dietary Coexposure to Benzo(a)pyrene on the Biotransformation and Distribution of ¹⁴C-Methoxychlor in the Channel Catfish (Ictalurus punctatus)
ToxSci Advance Access published on January 29, 2009
Toxicol. Sci. 2009 108: 320-329; doi:10.1093/toxsci/kfp018 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Donatella Carpi, Merja Korkalainen, Luisa Airoldi, Roberto Fanelli, Helen Hakansson, Virpi Muhonen, Juha Tuukkanen, Matti Viluksela, and Roberta Pastorelli

Dioxin-Sensitive Proteins in Differentiating Osteoblasts: Effects on Bone Formation In Vitro
ToxSci Advance Access published on February 6, 2009
Toxicol. Sci. 2009 108: 330-343; doi:10.1093/toxsci/kfp021 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Kazunobu Baba, Kazushi Okada, Tsutomu Kinoshita, and Susumu Imaoka

Bisphenol A Disrupts Notch Signaling by Inhibiting Gamma-Secretase Activity and Causes Eye Dysplasia of Xenopus laevis
ToxSci Advance Access published on February 13, 2009
Toxicol. Sci. 2009 108: 344-355; doi:10.1093/toxsci/kfp025 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Avina Paranjpe, Nicholas A. Cacalano, Wyatt R. Hume, and Anahid Jewett

N-Acetyl Cysteine Mediates Protection from 2-Hydroxyethyl Methacrylate Induced Apoptosis via Nuclear Factor Kappa B–Dependent and Independent Pathways: Potential Involvement of JNK
ToxSci Advance Access published on January 28, 2009
Toxicol. Sci. 2009 108: 356-366; doi:10.1093/toxsci/kfp010 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xuemei Fang, Yixing Feng, Zhimin Shi, and Jiayin Dai

Alterations of Cytokines and MAPK Signaling Pathways are Related to the Immunotoxic Effect of Perfluorononanoic Acid
ToxSci Advance Access published on February 5, 2009
Toxicol. Sci. 2009 108: 367-376; doi:10.1093/toxsci/kfp019 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Dina Schneider, Maria A. Manzan, Byung Sun Yoo, Robert B. Crawford, and Norbert Kaminski

Involvement of Blimp-1 and AP-1 Dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin–mediated Suppression of the IgM Response by B Cells
ToxSci Advance Access published on February 23, 2009
Toxicol. Sci. 2009 108: 377-388; doi:10.1093/toxsci/kfp028 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Roland Buesen, Elke Genschow, Birgitta Slawik, Anke Visan, Horst Spielmann, Andreas Luch, and Andrea Seiler

Embryonic Stem Cell Test Remastered: Comparison between the Validated EST and the New Molecular FACS-EST for Assessing Developmental Toxicity In Vitro
ToxSci Advance Access published on January 23, 2009
Toxicol. Sci. 2009 108: 389-400; doi:10.1093/toxsci/kfp012 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maja Aleksic, Emma Thain, Delphine Roger, Ouarda Saib, Michael Davies, Jin Li, Aynur Aptula, and Raniero Zazzeroni

Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment
ToxSci Advance Access published on February 16, 2009
Toxicol. Sci. 2009 108: 401-411; doi:10.1093/toxsci/kfp030 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Niclas Johansson, Per Eriksson, and Henrik Viberg

Neonatal Exposure to PFOS and PFOA in Mice Results in Changes in Proteins which are Important for Neuronal Growth and Synaptogenesis in the Developing Brain
ToxSci Advance Access published on February 11, 2009
Toxicol. Sci. 2009 108: 412-418; doi:10.1093/toxsci/kfp029 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Ryou Fukushima, Susumu Kanamori, Masahiro Hirashiba, Atsuko Hishikawa, Ri-ichi Muranaka, Masako Kaneto, and Hiroshi Kitagawa

Inhibiting the Teratogenicity of the Immunosuppressant Leflunomide in Mice by Supplementation of Exogenous Uridine
ToxSci Advance Access published on February 3, 2009
Toxicol. Sci. 2009 108: 419-426; doi:10.1093/toxsci/kfp022 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Yuan-Jie Li, Tian-Bao Song, Yan-Yan Cai, Jin-Song Zhou, Xin Song, Xuan Zhao, and Xiao-Lin Wu

Bisphenol A Exposure Induces Apoptosis and Upregulation of Fas/FasL and Caspase-3 Expression in the Testes of Mice
ToxSci Advance Access published on February 4, 2009
Toxicol. Sci. 2009 108: 427-436; doi:10.1093/toxsci/kfp024 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Pernille Reimer Hansen, Camilla Taxvig, Sofie Christiansen, Marta Axelstad, Julie Boberg, Maria Kristina Kiersgaard, Christine Nellemann, and Ulla Hass

Evaluation of Endocrine Disrupting Effects of Nitrate after In Utero Exposure in Rats and of Nitrate and Nitrite in the H295R and T-Screen Assay
ToxSci Advance Access published on February 3, 2009
Toxicol. Sci. 2009 108: 437-444; doi:10.1093/toxsci/kfp023 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Gina La Sala, Donatella Farini, and Massimo De Felici

Proapoptotic Effects of Lindane on Mouse Primordial Germ Cells
ToxSci Advance Access published on February 16, 2009
Toxicol. Sci. 2009 108: 445-451; doi:10.1093/toxsci/kfp027 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

RESPIRATORY TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract Jae Hyuck Sung, Jun Ho Ji, Jung Duck Park, Jin Uk Yoon, Dae Sung Kim, Ki Soo Jeon, Moon Yong Song, Jayoung Jeong, Beom Seok Han, Jeong Hee Han, Yong Hyun Chung, Hee Kyung Chang, Ji Hyun Lee, Myung Haing Cho, Bruce J. Kelman, and Il Je Yu

Subchronic Inhalation Toxicity of Silver Nanoparticles
ToxSci Advance Access published on November 25, 2008
Toxicol. Sci. 2009 108: 452-461; doi:10.1093/toxsci/kfn246 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Sheetal A. Thakur, Celine A. Beamer, Christopher T. Migliaccio, and Andrij Holian

Critical Role of MARCO in Crystalline Silica–Induced Pulmonary Inflammation
ToxSci Advance Access published on January 16, 2009
Toxicol. Sci. 2009 108: 462-471; doi:10.1093/toxsci/kfp011 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Dominique Lison, Julie Laloy, Ingrid Corazzari, Julie Muller, Virginie Rabolli, Nadtha Panin, François Huaux, Ivana Fenoglio, and Bice Fubini

Sintered Indium-Tin-Oxide (ITO) Particles: A New Pneumotoxic Entity
ToxSci Advance Access published on January 28, 2009
Toxicol. Sci. 2009 108: 472-481; doi:10.1093/toxsci/kfp014 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Lloyd Lecureux, Matthew Z. Dieter, David M. Nelson, Linda Watson, Harvey Wong, Brian Gemzik, Curtis D. Klaassen, and Lois D. Lehman-McKeeman

Hepatobiliary Disposition of Thyroid Hormone in Mrp2-Deficient TR^– Rats: Reduced Biliary Excretion of Thyroxine Glucuronide Does Not Prevent Xenobiotic-Induced Hypothyroidism
ToxSci Advance Access published on February 11, 2009
Toxicol. Sci. 2009 108: 482-491; doi:10.1093/toxsci/kfp026 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Bo Feng, Jinghai J. Xu, Yi-An Bi, Rouchelle Mireles, Ralph Davidson, David B. Duignan, Scott Campbell, Vsevolod E. Kostrubsky, Margaret C. Dunn, Arthur R. Smith, and Huifen F. Wang

Role of Hepatic Transporters in the Disposition and Hepatotoxicity of a HER2 Tyrosine Kinase Inhibitor CP-724,714
ToxSci Advance Access published on February 17, 2009
Toxicol. Sci. 2009 108: 492-500; doi:10.1093/toxsci/kfp033 [Abstract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

Erratum
Toxicol. Sci. 2009 108: 501; doi:10.1093/toxsci/kfp042 [Extract] [Full Text] [PDF] [Request Permissions]  

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