Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Elizabeth M. Ellis

Protection against Aflatoxin B₁ in Rat—A New Look at the Link between Toxicity, Carcinogenicity, and Metabolism
ToxSci Advance Access published on March 16, 2009
Toxicol. Sci. 2009 109: 1-3; doi:10.1093/toxsci/kfp052 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Kenneth T. Bogen, Alison C. Cullen, H. Christopher Frey, and Paul S. Price

Probabilistic Exposure Analysis for Chemical Risk Characterization
ToxSci Advance Access published on February 17, 2009
Toxicol. Sci. 2009 109: 4-17; doi:10.1093/toxsci/kfp036 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES, PART III

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Scott A. Reisman, Iván L. Csanaky, Ronnie L. Yeager, and Curtis D. Klaassen

Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase Activity
ToxSci Advance Access published on February 26, 2009
Toxicol. Sci. 2009 109: 24-30; doi:10.1093/toxsci/kfp045 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Scott A. Reisman, Iván L. Csanaky, Lauren M. Aleksunes, and Curtis D. Klaassen

Altered Disposition of Acetaminophen in Nrf2-null and Keap1-knockdown Mice
ToxSci Advance Access published on February 26, 2009
Toxicol. Sci. 2009 109: 31-40; doi:10.1093/toxsci/kfp047 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Bill D. Roebuck, Denise N. Johnson, Carrie Hayes Sutter, Patricia A. Egner, Peter F. Scholl, Marlin D. Friesen, Karen J. Baumgartner, Nicholas M. Ware, Sridevi Bodreddigari, John D. Groopman, Thomas W. Kensler, and Thomas R. Sutter

Transgenic Expression of Aflatoxin Aldehyde Reductase (AKR7A1) Modulates Aflatoxin B₁ Metabolism but not Hepatic Carcinogenesis in the Rat
ToxSci Advance Access published on January 23, 2009
Toxicol. Sci. 2009 109: 41-49; doi:10.1093/toxsci/kfp003 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Manabu Matsunawa, Yusuke Amano, Kaori Endo, Shigeyuki Uno, Toshiyuki Sakaki, Sachiko Yamada, and Makoto Makishima

The Aryl Hydrocarbon Receptor Activator Benzo[a]pyrene Enhances Vitamin D₃ Catabolism in Macrophages
ToxSci Advance Access published on February 25, 2009
Toxicol. Sci. 2009 109: 50-58; doi:10.1093/toxsci/kfp044 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract David Rouquié, Claire Friry-Santini, Frédéric Schorsch, Helen Tinwell, and Rémi Bars

Standard and Molecular NOAELs for Rat Testicular Toxicity Induced by Flutamide
ToxSci Advance Access published on March 19, 2009
Toxicol. Sci. 2009 109: 59-65; doi:10.1093/toxsci/kfp056 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Stephanie P. Jones and Sean W. Kennedy

Chicken Embryo Cardiomyocyte Cultures—A New Approach for Studying Effects of Halogenated Aromatic Hydrocarbons in the Avian Heart
ToxSci Advance Access published on February 17, 2009
Toxicol. Sci. 2009 109: 66-74; doi:10.1093/toxsci/kfp039 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Tisha C. King Heiden, Jan Spitsbergen, Warren Heideman, and Richard E. Peterson

Persistent Adverse Effects on Health and Reproduction Caused by Exposure of Zebrafish to 2,3,7,8-Tetrachlorodibenzo-p-dioxin During Early Development and Gonad Differentiation
ToxSci Advance Access published on March 11, 2009
Toxicol. Sci. 2009 109: 75-87; doi:10.1093/toxsci/kfp048 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Cristina Lagido, Debbie McLaggan, Aileen Flett, Jonathan Pettitt, and L. Anne Glover

Rapid Sublethal Toxicity Assessment Using Bioluminescent Caenorhabditis elegans, a Novel Whole-Animal Metabolic Biosensor
ToxSci Advance Access published on March 18, 2009
Toxicol. Sci. 2009 109: 88-95; doi:10.1093/toxsci/kfp058 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Jianyong Wang, Jeffrey R. Sawyer, Ling Chen, Tao Chen, Masamitsu Honma, Nan Mei, and Martha M. Moore

The Mouse Lymphoma Assay Detects Recombination, Deletion, and Aneuploidy
ToxSci Advance Access published on February 23, 2009
Toxicol. Sci. 2009 109: 96-105; doi:10.1093/toxsci/kfp037 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Jamie C. DeWitt, Carey B. Copeland, and Robert W. Luebke

Suppression of Humoral Immunity by Perfluorooctanoic Acid is Independent of Elevated Serum Corticosterone Concentration in Mice
ToxSci Advance Access published on February 23, 2009
Toxicol. Sci. 2009 109: 106-112; doi:10.1093/toxsci/kfp040 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Unni C. Nygaard, Jitka S. Hansen, Mari Samuelsen, Torunn Alberg, Calin D. Marioara, and Martinus Løvik

Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice
ToxSci Advance Access published on March 17, 2009
Toxicol. Sci. 2009 109: 113-123; doi:10.1093/toxsci/kfp057 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Haseeb Ahmad Khan, Abdullah Saleh Alhomida, and Ibrahim Abdulwahid Arif

Neurovestibular Toxicities of Acrylonitrile and Iminodipropionitrile in Rats: A Comparative Evaluation of Putative Mechanisms and Target Sites
ToxSci Advance Access published on February 25, 2009
Toxicol. Sci. 2009 109: 124-131; doi:10.1093/toxsci/kfp043 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Frank O. Johnson, Janice E. Chambers, Carole A. Nail, Sumalee Givaruangsawat, and Russell L. Carr

Developmental Chlorpyrifos and Methyl Parathion Exposure Alters Radial-Arm Maze Performance in Juvenile and Adult Rats
ToxSci Advance Access published on March 17, 2009
Toxicol. Sci. 2009 109: 132-142; doi:10.1093/toxsci/kfp053 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Chikanori Kuramori, Yasuyoshi Hase, Koichi Hoshikawa, Keiko Watanabe, Takeyuki Nishi, Takako Hishiki, Tomoyoshi Soga, Akihiro Nashimoto, Yasuaki Kabe, Yuki Yamaguchi, Hajime Watanabe, Kohsuke Kataoka, Makoto Suematsu, and Hiroshi Handa

Mono-(2-ethylhexyl) phthalate Targets Glycogen Debranching Enzyme and Affects Glycogen Metabolism in Rat Testis
ToxSci Advance Access published on February 23, 2009
Toxicol. Sci. 2009 109: 143-151; doi:10.1093/toxsci/kfp041 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Jürgen Pauluhn

Pulmonary Toxicity and Fate of Agglomerated 10 and 40 nm Aluminum Oxyhydroxides following 4-Week Inhalation Exposure of Rats: Toxic Effects are Determined by Agglomerated, not Primary Particle Size
ToxSci Advance Access published on February 27, 2009
Toxicol. Sci. 2009 109: 152-167; doi:10.1093/toxsci/kfp046 [Abstract] [Full Text] [PDF] [Request Permissions]  

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