Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Kylee Eblin

Potential Clinical Significance of EGFR-Mediated Signaling following Inorganic Arsenic Exposure in Human Lung
ToxSci Advance Access published on April 15, 2009
Toxicol. Sci. 2009 109: 169-171; doi:10.1093/toxsci/kfp071 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Rosalie K. Elespuru, Rajiv Agarwal, Aisar H. Atrakchi, C. Anita H. Bigger, Robert H. Heflich, Devaraya R. Jagannath, Dan D. Levy, Martha M. Moore, Yanli Ouyang, Timothy W. Robison, Rene E. Sotomayor, Michael C. Cimino, and Kerry L. Dearfield

Current and Future Application of Genetic Toxicity Assays: The Role and Value of In Vitro Mammalian Assays
ToxSci Advance Access published on March 31, 2009
Toxicol. Sci. 2009 109: 172-179; doi:10.1093/toxsci/kfp067 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Karen H. Watanabe, Zhenhong Li, Kevin J. Kroll, Daniel L. Villeneuve, Natàlia Garcia-Reyero, Edward F. Orlando, Maria S. Sepúlveda, Timothy W. Collette, Drew R. Ekman, Gerald T. Ankley, and Nancy D. Denslow

A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis in Male Fathead Minnows Exposed to 17-Ethinylestradiol and 17β-Estradiol
ToxSci Advance Access published on April 8, 2009
Toxicol. Sci. 2009 109: 180-192; doi:10.1093/toxsci/kfp069 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jennifer M. Phillips, Lyle D. Burgoon, and Jay I. Goodman

Phenobarbital Elicits Unique, Early Changes in the Expression of Hepatic Genes that Affect Critical Pathways in Tumor-Prone B6C3F1 Mice
ToxSci Advance Access published on March 6, 2009
Toxicol. Sci. 2009 109: 193-205; doi:10.1093/toxsci/kfp050 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Jana M. Weiss, Patrik L. Andersson, Marja H. Lamoree, Pim E. G. Leonards, Stefan P. J. van Leeuwen, and Timo Hamers

Competitive Binding of Poly- and Perfluorinated Compounds to the Thyroid Hormone Transport Protein Transthyretin
ToxSci Advance Access published on March 17, 2009
Toxicol. Sci. 2009 109: 206-216; doi:10.1093/toxsci/kfp055 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Alicia R. Timme-Laragy, Lindsey A. Van Tiem, Elwood A. Linney, and Richard T. Di Giulio

Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish
ToxSci Advance Access published on February 20, 2009
Toxicol. Sci. 2009 109: 217-227; doi:10.1093/toxsci/kfp038 [Abstract] [Full Text] [PDF] [Request Permissions]  

GENETIC TOXICOLOGY

Get checked abstract Tingting Li and James S. Woods

Cloning, Expression, and Biochemical Properties of CPOX4, a Genetic Variant of Coproporphyrinogen Oxidase that Affects Susceptibilitly to Mercury Toxicity in Humans
ToxSci Advance Access published on April 1, 2009
Toxicol. Sci. 2009 109: 228-236; doi:10.1093/toxsci/kfp066 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Stephen B. Pruett, Bing Cheng, Ruping Fan, Wei Tan, and Thomas Sebastian

Oxidative Stress and Sodium Methyldithiocarbamate–Induced Modulation of the Macrophage Response to Lipopolysaccharide In Vivo
ToxSci Advance Access published on April 1, 2009
Toxicol. Sci. 2009 109: 237-246; doi:10.1093/toxsci/kfp054 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Yuhui Shi, Katie Porter, Narayanan Parameswaran, Hee Kyong Bae, and James J. Pestka

Role of GRP78/BiP Degradation and ER Stress in Deoxynivalenol-Induced Interleukin-6 Upregulation in the Macrophage
ToxSci Advance Access published on March 31, 2009
Toxicol. Sci. 2009 109: 247-255; doi:10.1093/toxsci/kfp060 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jeroen A. J. Vanoirbeek, Vanessa De Vooght, Nicholas Synhaeve, Benoit Nemery, and Peter H. M. Hoet

Is Toluene Diamine a Sensitizer and is there Cross-Reactivity between Toluene Diamine and Toluene Diisocyanate?
ToxSci Advance Access published on March 30, 2009
Toxicol. Sci. 2009 109: 256-264; doi:10.1093/toxsci/kfp065 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Stephen B. Pruett, Ruping Fan, Qiang Zheng, and Carlton Schwab

Patterns of Immunotoxicity Associated with Chronic as Compared with Acute Exposure to Chemical or Physical Stressors and their Relevance with Regard to the Role of Stress and with Regard to Immunotoxicity Testing
ToxSci Advance Access published on April 7, 2009
Toxicol. Sci. 2009 109: 265-275; doi:10.1093/toxsci/kfp073 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Wei-Yuan Hou, Ding-Xin Long, and Yi-Jun Wu

The Homeostasis of Phosphatidylcholine and Lysophosphatidylcholine in Nervous Tissues of Mice was not Disrupted after Administration of Tri-o-cresyl Phosphate
ToxSci Advance Access published on April 6, 2009
Toxicol. Sci. 2009 109: 276-285; doi:10.1093/toxsci/kfp068 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Oskar Karlsson, Nils Gunnar Lindquist, Eva B. Brittebo, and Erika Roman

Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents
ToxSci Advance Access published on March 25, 2009
Toxicol. Sci. 2009 109: 286-295; doi:10.1093/toxsci/kfp062 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Vernon A. Benignus, Philip J. Bushnell, William K. Boyes, Chris Eklund, and Elaina M. Kenyon

Neurobehavioral Effects of Acute Exposure to Four Solvents: Meta-analyses
ToxSci Advance Access published on April 1, 2009
Toxicol. Sci. 2009 109: 296-305; doi:10.1093/toxsci/kfp063 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Henrik Viberg

Exposure to Polybrominated Diphenyl Ethers 203 and 206 during the Neonatal Brain Growth Spurt Affects Proteins Important for Normal Neurodevelopment in Mice
ToxSci Advance Access published on April 20, 2009
Toxicol. Sci. 2009 109: 306-311; doi:10.1093/toxsci/kfp074 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Simon S. Wong, Alana Thomas, Brian Barbaris, R. Clark Lantz, and Mark L. Witten

Pulmonary Evaluation of Permissible Exposure Limit of Syntroleum S-8 Synthetic Jet Fuel in Mice
ToxSci Advance Access published on April 7, 2009
Toxicol. Sci. 2009 109: 312-320; doi:10.1093/toxsci/kfp072 [Abstract] [Full Text] [PDF] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Teresa L. Leavens and Susan J. Borghoff

Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to 2u-Globulin
ToxSci Advance Access published on March 6, 2009
Toxicol. Sci. 2009 109: 321-335; doi:10.1093/toxsci/kfp049 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY ASSESSMENT

Get checked abstract Max Sieber, Dana Hoffmann, Melanie Adler, Vishal S. Vaidya, Matthew Clement, Joseph V. Bonventre, Nadine Zidek, Eva Rached, Alexander Amberg, John J. Callanan, Wolfgang Dekant, and Angela Mally

Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity
ToxSci Advance Access published on April 6, 2009
Toxicol. Sci. 2009 109: 336-349; doi:10.1093/toxsci/kfp070 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract ClarLynda R. Williams-Devane, Maritja A. Wolf, and Ann M. Richard

Toward a Public Toxicogenomics Capability for Supporting Predictive Toxicology: Survey of Current Resources and Chemical Indexing of Experiments in GEO and ArrayExpress
ToxSci Advance Access published on March 30, 2009
Toxicol. Sci. 2009 109: 358-371; doi:10.1093/toxsci/kfp061 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Tessa M. Scown, Ronny van Aerle, Blair D. Johnston, Susan Cumberland, Jamie R. Lead, Richard Owen, and Charles R. Tyler

High Doses of Intravenously Administered Titanium Dioxide Nanoparticles Accumulate in the Kidneys of Rainbow Trout but with no Observable Impairment of Renal Function
ToxSci Advance Access published on March 30, 2009
Toxicol. Sci. 2009 109: 372-380; doi:10.1093/toxsci/kfp064 [Abstract] [Full Text] [PDF] [Request Permissions]  

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