Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Matthew J. Campen

Nitric Oxide Synthase: "Enzyme Zero" in Air Pollution–Induced Vascular Toxicity
ToxSci Advance Access published on April 16, 2009
Toxicol. Sci. 2009 110: 1-3; doi:10.1093/toxsci/kfp078 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Silas W. Smith

Chiral Toxicology: It's the Same Thing...Only Different
ToxSci Advance Access published on May 4, 2009
Toxicol. Sci. 2009 110: 4-30; doi:10.1093/toxsci/kfp097 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract MaryJane K. Selgrade, Christal C. Bowman, Gregory S. Ladics, Laura Privalle, and Susan A. Laessig

Safety Assessment of Biotechnology Products for Potential Risk of Food Allergy: Implications of New Research
ToxSci Advance Access published on April 10, 2009
Toxicol. Sci. 2009 110: 31-39; doi:10.1093/toxsci/kfp075 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES, PART IV

James S. MacDonald and Richard T. Robertson

Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry
ToxSci Advance Access published on May 12, 2009
Toxicol. Sci. 2009 110: 40-46; doi:10.1093/toxsci/kfp088 [Extract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Yue J. Cui, Lauren M. Aleksunes, Yuji Tanaka, Michael J. Goedken, and Curtis D. Klaassen

Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice
ToxSci Advance Access published on April 30, 2009
Toxicol. Sci. 2009 110: 47-60; doi:10.1093/toxsci/kfp094 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Sudheer R. Beedanagari, Ilona Bebenek, Peter Bui, and Oliver Hankinson

Resveratrol Inhibits Dioxin-Induced Expression of Human CYP1A1 and CYP1B1 by Inhibiting Recruitment of the Aryl Hydrocarbon Receptor Complex and RNA Polymerase II to the Regulatory Regions of the Corresponding Genes
ToxSci Advance Access published on April 17, 2009
Toxicol. Sci. 2009 110: 61-67; doi:10.1093/toxsci/kfp079 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Stephen Nesnow, William Ward, Tanya Moore, Hongzu Ren, and Susan D. Hester

Discrimination of Tumorigenic Triazole Conazoles from Phenobarbital by Transcriptional Analyses of Mouse Liver Gene Expression
ToxSci Advance Access published on April 10, 2009
Toxicol. Sci. 2009 110: 68-83; doi:10.1093/toxsci/kfp076 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Christophe Cavin, Thierry Delatour, Maricel Marin-Kuan, François Fenaille, Daisy Holzhäuser, Gabrièla Guignard, Claudine Bezençon, Dominique Piguet, Véronique Parisod, Janique Richoz-Payot, and Benoît Schilter

Ochratoxin A–Mediated DNA and Protein Damage: Roles of Nitrosative and Oxidative Stresses
ToxSci Advance Access published on May 4, 2009
Toxicol. Sci. 2009 110: 84-94; doi:10.1093/toxsci/kfp090 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Craig N. Harvey, Mahmoud Esmail, Qi Wang, Andrew I. Brooks, Rob Zachow, and Mehmet Uzumcu

Effect of the Methoxychlor Metabolite HPTE on the Rat Ovarian Granulosa Cell Transcriptome In Vitro
ToxSci Advance Access published on May 4, 2009
Toxicol. Sci. 2009 110: 95-106; doi:10.1093/toxsci/kfp089 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Si Zhang, Steven J. Bursian, Pamela A. Martin, Hing M. Chan, Gregg Tomy, Vince P. Palace, Greg J. Mayne, and Jonathan W. Martin

Reproductive and Developmental Toxicity of a Pentabrominated Diphenyl Ether Mixture, DE-71, to Ranch Mink (Mustela vison) and Hazard Assessment for Wild Mink in the Great Lakes Region
ToxSci Advance Access published on May 6, 2009
Toxicol. Sci. 2009 110: 107-116; doi:10.1093/toxsci/kfp095 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Esther de Jong, Jochem Louisse, Miriam Verwei, Bas J. Blaauboer, Johannes J. M. van de Sandt, Ruud A. Woutersen, Ivonne M. C. M. Rietjens, and Aldert H. Piersma

Relative Developmental Toxicity of Glycol Ether Alkoxy Acid Metabolites in the Embryonic Stem Cell Test as compared with the In Vivo Potency of their Parent Compounds
ToxSci Advance Access published on April 28, 2009
Toxicol. Sci. 2009 110: 117-124; doi:10.1093/toxsci/kfp083 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Peter Josef Hofmann, Lutz Schomburg, and Josef Köhrle

Interference of Endocrine Disrupters with Thyroid Hormone Receptor–Dependent Transactivation
ToxSci Advance Access published on April 29, 2009
Toxicol. Sci. 2009 110: 125-137; doi:10.1093/toxsci/kfp086 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Leshuai W. Zhang and Nancy A. Monteiro-Riviere

Mechanisms of Quantum Dot Nanoparticle Cellular Uptake
ToxSci Advance Access published on May 4, 2009
Toxicol. Sci. 2009 110: 138-155; doi:10.1093/toxsci/kfp087 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Eun-Sook Y. Lee, Zhaobao Yin, Dejan Milatovic, Haiyan Jiang, and Michael Aschner

Estrogen and Tamoxifen Protect against Mn-Induced Toxicity in Rat Cortical Primary Cultures of Neurons and Astrocytes
ToxSci Advance Access published on April 21, 2009
Toxicol. Sci. 2009 110: 156-167; doi:10.1093/toxsci/kfp081 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Matthew T. Martin, Elizabeth Mendez, Daniel G. Corum, Richard S. Judson, Robert J. Kavlock, Daniel M. Rotroff, and David J. Dix

Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database
ToxSci Advance Access published on April 10, 2009
Toxicol. Sci. 2009 110: 181-190; doi:10.1093/toxsci/kfp080 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

HIGHLIGHTED ARTICLE:

Get checked abstract Timothy R. Nurkiewicz, Dale W. Porter, Ann F. Hubbs, Samuel Stone, Bean T. Chen, David G. Frazer, Matthew A. Boegehold, and Vincent Castranova

Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling
ToxSci Advance Access published on March 6, 2009
Toxicol. Sci. 2009 110: 191-203; doi:10.1093/toxsci/kfp051 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jennifer E. Foreman, Shu-Ching Chang, David J. Ehresman, John L. Butenhoff, Cherie R. Anderson, Prajakta S. Palkar, Boo-Hyon Kang, Frank J. Gonzalez, and Jeffrey M. Peters

Differential Hepatic Effects of Perfluorobutyrate Mediated by Mouse and Human PPAR-
ToxSci Advance Access published on April 9, 2009
Toxicol. Sci. 2009 110: 204-211; doi:10.1093/toxsci/kfp077 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Antonia A. Nemec and Aaron Barchowsky

Signal Transducer and Activator of Transcription 1 (STAT1) is Essential for Chromium Silencing of Gene Induction in Human Airway Epithelial Cells
ToxSci Advance Access published on April 29, 2009
Toxicol. Sci. 2009 110: 212-223; doi:10.1093/toxsci/kfp084 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Mehdi S. Hazari, Najwa Haykal-Coates, Darrell W. Winsett, Daniel L. Costa, and Aimen K. Farraj

Continuous Electrocardiogram Reveals Differences in the Short-Term Cardiotoxic Response of Wistar-Kyoto and Spontaneously Hypertensive Rats to Doxorubicin
ToxSci Advance Access published on April 30, 2009
Toxicol. Sci. 2009 110: 224-234; doi:10.1093/toxsci/kfp092 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Alison H. Harrill, Pamela K. Ross, Daniel M. Gatti, David W. Threadgill, and Ivan Rusyn

Population-Based Discovery of Toxicogenomics Biomarkers for Hepatotoxicity Using a Laboratory Strain Diversity Panel
ToxSci Advance Access published on May 6, 2009
Toxicol. Sci. 2009 110: 235-243; doi:10.1093/toxsci/kfp096 [Abstract] [Full Text] [PDF] [Request Permissions]  

LETTERS TO THE EDITOR

Jordi Llorens, Carla Soler-Martín, Blanca Cutillas, and Sandra Saldaña-Ruíz

Nervous and Vestibular Toxicities of Acrylonitrile and Iminodipropionitrile
ToxSci Advance Access published on April 29, 2009
Toxicol. Sci. 2009 110: 244-245; doi:10.1093/toxsci/kfp082 [Extract] [Full Text] [PDF] [Request Permissions]  

Haseeb Ahmad Khan, Abdullah Saleh Alhomida, and Ibrahim Abdulwahid Arif

On the Mechanism of Nitriles Toxicity
ToxSci Advance Access published on April 28, 2009
Toxicol. Sci. 2009 110: 246-248; doi:10.1093/toxsci/kfp085 [Extract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2009 110: 249-250; doi:10.1093/toxsci/kfp110 [Extract] [Full Text] [PDF] [Request Permissions]  

COVER

COVER
Toxicol. Sci. 2009 110: NP; doi:10.1093/toxsci/kfp119 [PDF] [Request Permissions]  

STANDING MATTERS

Editorial Board
Toxicol. Sci. 2009 110: NP; doi:10.1093/toxsci/kfp120 [PDF] [Request Permissions]  

CONTENTS
Toxicol. Sci. 2009 110: NP; doi:10.1093/toxsci/kfp118 [PDF] [Request Permissions]  

SUBSCRIPTIONS
Toxicol. Sci. 2009 110: NP; doi:10.1093/toxsci/kfp122 [PDF] [Request Permissions]  

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