Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

John D. Hayes, Albena T. Dinkova-Kostova, and Michael McMahon

Cross-talk between Transcription Factors AhR and Nrf2: Lessons for Cancer Chemoprevention from Dioxin
ToxSci Advance Access published on July 23, 2009
Toxicol. Sci. 2009 111: 199-201; doi:10.1093/toxsci/kfp168 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

Get checked abstract Steven O. Simmons, Chun-Yang Fan, and Ram Ramabhadran

Cellular Stress Response Pathway System as a Sentinel Ensemble in Toxicological Screening
ToxSci Advance Access published on June 30, 2009
Toxicol. Sci. 2009 111: 202-225; doi:10.1093/toxsci/kfp140 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM SERIES - PART VI

Get checked abstract Elaine A. Cohen Hubal

Biologically Relevant Exposure Science for 21st Century Toxicity Testing
ToxSci Advance Access published on July 14, 2009
Toxicol. Sci. 2009 111: 226-232; doi:10.1093/toxsci/kfp159 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Thomas Hartung and George Daston

Are In Vitro Tests Suitable for Regulatory Use?
ToxSci Advance Access published on July 17, 2009
Toxicol. Sci. 2009 111: 233-237; doi:10.1093/toxsci/kfp149 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Ronnie L. Yeager, Scott A. Reisman, Lauren M. Aleksunes, and Curtis D. Klaassen

Introducing the "TCDD-Inducible AhR-Nrf2 Gene Battery"
ToxSci Advance Access published on May 27, 2009
Toxicol. Sci. 2009 111: 238-246; doi:10.1093/toxsci/kfp115 [Abstract] [Full Text] [PDF] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jun Li, Job C. Tharappel, Sung Gu Han, Austin H. Cantor, Eun Y. Lee, C. Gary Gairola, and Howard P. Glauert

Effect of Dietary Selenium and Cigarette Smoke on Pulmonary Cell Proliferation in Mice
ToxSci Advance Access published on July 13, 2009
Toxicol. Sci. 2009 111: 247-253; doi:10.1093/toxsci/kfp151 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Shaimaa Ahmed, Eivind Valen, Albin Sandelin, and Jason Matthews

Dioxin Increases the Interaction Between Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha at Human Promoters
ToxSci Advance Access published on July 2, 2009
Toxicol. Sci. 2009 111: 254-266; doi:10.1093/toxsci/kfp144 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Yang-Ming Tseng, Shih-Meng Tsai, Sheng-Yi Chen, Chun-Chin Lin, Yi-Ru Jin, Wei-Hao Yeh, Yi-Ru Wu, Ing-Jun Chen, Jang-Hwa Lee, and Li-Yu Tsai

Roles of the Genetic Polymorphisms of Alcohol-Metabolizing Enzymes on the Immunology in High-Risk Drinkers
ToxSci Advance Access published on June 30, 2009
Toxicol. Sci. 2009 111: 267-276; doi:10.1093/toxsci/kfp143 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Chidozie J. Amuzie, Junko Shinozuka, and James J. Pestka

Induction of Suppressors of Cytokine Signaling by the Trichothecene Deoxynivalenol in the Mouse
ToxSci Advance Access published on July 22, 2009
Toxicol. Sci. 2009 111: 277-287; doi:10.1093/toxsci/kfp150 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Patrick J. Shaw, Kevin M. Beggs, Erica M. Sparkenbaugh, Christine M. Dugan, Patricia E. Ganey, and Robert A. Roth

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity
ToxSci Advance Access published on July 28, 2009
Toxicol. Sci. 2009 111: 288-301; doi:10.1093/toxsci/kfp163 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Eisuke Kobayashi, Masanori Kobayashi, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi

Halothane-Induced Liver Injury is Mediated by Interleukin-17 in Mice
ToxSci Advance Access published on July 24, 2009
Toxicol. Sci. 2009 111: 302-310; doi:10.1093/toxsci/kfp165 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Nathan J. Hickey, Doug Crump, Stephanie P. Jones, and Sean W. Kennedy

Effects of 18 Perfluoroalkyl Compounds on mRNA Expression in Chicken Embryo Hepatocyte Cultures
ToxSci Advance Access published on July 17, 2009
Toxicol. Sci. 2009 111: 311-320; doi:10.1093/toxsci/kfp160 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Sandra Meme, André-Guilhem Calas, Céline Montécot, Oliver Richard, Hélène Gautier, Thierry Gefflaut, Bich Thuy Doan, William Même, Jacques Pichon, and Jean-Claude Beloeil

MRI Characterization of Structural Mouse Brain Changes in Response to Chronic Exposure to the Glufosinate Ammonium Herbicide
ToxSci Advance Access published on July 28, 2009
Toxicol. Sci. 2009 111: 321-330; doi:10.1093/toxsci/kfp174 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Romina María Uranga, Norma María Giusto, and Gabriela Alejandra Salvador

Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats
ToxSci Advance Access published on July 16, 2009
Toxicol. Sci. 2009 111: 331-344; doi:10.1093/toxsci/kfp152 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract George C.-T. Jiang, Sam Hughes, Stephen R. Stürzenbaum, Lars Evje, Tore Syversen, and Michael Aschner

Caenorhabditis elegans Metallothioneins Protect against Toxicity Induced by Depleted Uranium
ToxSci Advance Access published on July 17, 2009
Toxicol. Sci. 2009 111: 345-354; doi:10.1093/toxsci/kfp161 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Xuan Zhang, Merle G. Paule, Glenn D. Newport, Xiaoju Zou, Natalya Sadovova, Marc S. Berridge, Scott M. Apana, Joseph P. Hanig, William Slikker, Jr, and Cheng Wang

A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using ¹⁸F-Annexin V
ToxSci Advance Access published on July 28, 2009
Toxicol. Sci. 2009 111: 355-361; doi:10.1093/toxsci/kfp167 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Delphine Waniusiow, Pierre Campo, Thomas Venet, Benoît Cossec, Frédéric Cosnier, Dominique Beydon, Benoît Rieger, Manuella Burgart, Luc Ferrari, and Cécile Parietti-Winkler

Toluene-Induced Hearing Loss in the Guinea Pig
ToxSci Advance Access published on July 27, 2009
Toxicol. Sci. 2009 111: 362-371; doi:10.1093/toxsci/kfp169 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

RESPIRATORY TOXICOLOGY

Get checked abstract John B. Morris and Alan R. Buckpitt

Upper Respiratory Tract Uptake of Naphthalene
ToxSci Advance Access published on July 31, 2009
Toxicol. Sci. 2009 111: 383-391; doi:10.1093/toxsci/kfp138 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rajiv K. Saxena, M. Ian Gilmour, Mette C. Schladweiler, Michael McClure, Michael Hays, and Urmila P. Kodavanti

Differential Pulmonary Retention of Diesel Exhaust Particles in Wistar Kyoto and Spontaneously Hypertensive Rats
ToxSci Advance Access published on July 27, 2009
Toxicol. Sci. 2009 111: 392-401; doi:10.1093/toxsci/kfp164 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Jeffrey D. Vassallo, Evan B. Janovitz, Debra M. Wescott, Chris Chadwick, Linda J. Lowe-Krentz, and Lois D. Lehman-McKeeman

Biomarkers of Drug-Induced Skeletal Muscle Injury in the Rat: Troponin I and Myoglobin
ToxSci Advance Access published on July 23, 2009
Toxicol. Sci. 2009 111: 402-412; doi:10.1093/toxsci/kfp166 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Maria Elena Rodríguez-García, Adoración G. Quiroga, José Castro, Alberto Ortiz, Patricio Aller, and Felicísima Mata

Inhibition of p38-MAPK Potentiates Cisplatin-Induced Apoptosis via GSH Depletion and Increases Intracellular Drug Accumulation in Growth-Arrested Kidney Tubular Epithelial Cells
ToxSci Advance Access published on July 3, 2009
Toxicol. Sci. 2009 111: 413-423; doi:10.1093/toxsci/kfp145 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract William J. Jo, Alex Loguinov, Henri Wintz, Michelle Chang, Allan H. Smith, Dave Kalman, Luoping Zhang, Martyn T. Smith, and Chris D. Vulpe

Comparative Functional Genomic Analysis Identifies Distinct and Overlapping Sets of Genes Required for Resistance to Monomethylarsonous Acid (MMA^III) and Arsenite (As^III) in Yeast
ToxSci Advance Access published on July 27, 2009
Toxicol. Sci. 2009 111: 424-436; doi:10.1093/toxsci/kfp162 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Sara L. Holland and Simon V. Avery

Actin-Mediated Endocytosis Limits Intracellular Cr Accumulation and Cr Toxicity during Chromate Stress
ToxSci Advance Access published on July 23, 2009
Toxicol. Sci. 2009 111: 437-446; doi:10.1093/toxsci/kfp170 [Abstract] [Full Text] [PDF] [Request Permissions]  

STANDING MATERIAL

Editorial Board
Toxicol. Sci. 2009 111: NP; doi:10.1093/toxsci/kfp209 [PDF] [Request Permissions]  

SUBSCRIPTIONS
Toxicol. Sci. 2009 111: NP; doi:10.1093/toxsci/kfp210 [PDF] [Request Permissions]  

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