Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Steven O. Simmons

Hypoxia Response: A Model Toxicity Pathway for High-Throughput Screening
ToxSci Advance Access published on September 3, 2009
Toxicol. Sci. 2009 112: 1-3; doi:10.1093/toxsci/kfp193 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEW

FORUM SERIES, PART VII

Get checked abstract Robert E. Chapin and Donald B. Stedman

Endless Possibilities: Stem Cells and the Vision for Toxicology Testing in the 21st Century
ToxSci Advance Access published on August 24, 2009
Toxicol. Sci. 2009 112: 17-22; doi:10.1093/toxsci/kfp202 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Miyoung Yoon, Andy Nong, Harvey J. Clewell, III, Michael D. Taylor, David C. Dorman, and Melvin E. Andersen

Lactational Transfer of Manganese in Rats: Predicting Manganese Tissue Concentration in the Dam and Pups from Inhalation Exposure with a Pharmacokinetic Model
ToxSci Advance Access published on September 2, 2009
Toxicol. Sci. 2009 112: 23-43; doi:10.1093/toxsci/kfp197 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Miyoung Yoon, Andy Nong, Harvey J. Clewell, III, Michael D. Taylor, David C. Dorman, and Melvin E. Andersen

Evaluating Placental Transfer and Tissue Concentrations of Manganese in the Pregnant Rat and Fetuses after Inhalation Exposures with a PBPK Model
ToxSci Advance Access published on September 2, 2009
Toxicol. Sci. 2009 112: 44-58; doi:10.1093/toxsci/kfp198 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Jessica M. Weems, Ned. S. Cutler, Chad Moore, William K. Nichols, David Martin, Evan Makin, John G. Lamb, and Garold S. Yost

3-Methylindole is Mutagenic and a Possible Pulmonary Carcinogen
ToxSci Advance Access published on August 21, 2009
Toxicol. Sci. 2009 112: 59-67; doi:10.1093/toxsci/kfp201 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENDOCRINE TOXICOLOGY

Get checked abstract Thuy T. B. Vo and Eui-Bae Jeung

An Evaluation of Estrogenic Activity of Parabens Using Uterine Calbindin-D9k Gene in an Immature Rat Model
ToxSci Advance Access published on August 4, 2009
Toxicol. Sci. 2009 112: 68-77; doi:10.1093/toxsci/kfp176 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Susan C. Laws, Michelle Hotchkiss, Janet Ferrell, Saro Jayaraman, Lesley Mills, Walker Modic, Nicole Tinfo, Melanie Fraites, Tammy Stoker, and Ralph Cooper

Chlorotriazine Herbicides and Metabolites Activate an ACTH-dependent Release of Corticosterone in Male Wistar Rats
ToxSci Advance Access published on August 18, 2009
Toxicol. Sci. 2009 112: 78-87; doi:10.1093/toxsci/kfp190 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Melanie J. P. Fraites, Ralph L. Cooper, Angela Buckalew, Saro Jayaraman, Lesley Mills, and Susan C. Laws

Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat
ToxSci Advance Access published on August 26, 2009
Toxicol. Sci. 2009 112: 88-99; doi:10.1093/toxsci/kfp194 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Fang Liu, Sahoko Ichihara, Sahabudeen Sheik Mohideen, Uka Sai, Junzoh Kitoh, and Gaku Ichihara

Comparative Study on Susceptibility to 1-Bromopropane in Three Mice Strains
ToxSci Advance Access published on July 28, 2009
Toxicol. Sci. 2009 112: 100-110; doi:10.1093/toxsci/kfp173 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Todd L. Watterson, Brett Hamilton, Randy Martin, and Roger A. Coulombe, Jr

Urban Particulate Matter Causes ER Stress and the Unfolded Protein Response in Human Lung Cells
ToxSci Advance Access published on August 12, 2009
Toxicol. Sci. 2009 112: 111-122; doi:10.1093/toxsci/kfp186 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Colin M. North, Robert B. Crawford, Haitian Lu, and Norbert E. Kaminski

Simultaneous In Vivo Time Course and Dose Response Evaluation for TCDD-Induced Impairment of the LPS-stimulated Primary IgM Response
ToxSci Advance Access published on August 12, 2009
Toxicol. Sci. 2009 112: 123-132; doi:10.1093/toxsci/kfp187 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Amjad Mustafa, Steven D. Holladay, Sharon Witonsky, Kurt Zimmerman, Christopher M. Reilly, D. Phillip Sponenberg, Danielle A. Weinstein, Ebru Karpuzoglu, and Robert M. Gogal, Jr

Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Disrupts B-Cell Lymphopoiesis and Exacerbates Autoimmune Disease in 24-Week-Old SNF₁ Mice
ToxSci Advance Access published on August 10, 2009
Toxicol. Sci. 2009 112: 133-143; doi:10.1093/toxsci/kfp177 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Alberto Y. Limón-Flores, Rommel Chacón-Salinas, Gerardo Ramos, and Stephen E. Ullrich

Mast Cells Mediate the Immune Suppression Induced by Dermal Exposure to JP-8 Jet Fuel
ToxSci Advance Access published on September 2, 2009
Toxicol. Sci. 2009 112: 144-152; doi:10.1093/toxsci/kfp181 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Menghang Xia, Ruili Huang, Yi Sun, Gregg L. Semenza, Shelley Force Aldred, Kristine L. Witt, James Inglese, Raymond R. Tice, and Christopher P. Austin

Identification of Chemical Compounds that Induce HIF-1 Activity
ToxSci Advance Access published on June 5, 2009
Toxicol. Sci. 2009 112: 153-163; doi:10.1093/toxsci/kfp123 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract G. Frank Gerberick, John A. Troutman, Leslie M. Foertsch, Jeffrey D. Vassallo, Mike Quijano, Roy L. M. Dobson, Carsten Goebel, and Jean-Pierre Lepoittevin

Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System
ToxSci Advance Access published on September 11, 2009
Toxicol. Sci. 2009 112: 164-174; doi:10.1093/toxsci/kfp192 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Ingrid Stavenes Andersen, Øyvind Albert Voie, Frode Fonnum, and Espen Mariussen

Effects of Methyl Mercury in Combination with Polychlorinated Biphenyls and Brominated Flame Retardants on the Uptake of Glutamate in Rat Brain Synaptosomes: A Mathematical Approach for the Study of Mixtures
ToxSci Advance Access published on August 21, 2009
Toxicol. Sci. 2009 112: 175-184; doi:10.1093/toxsci/kfp178 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Oskar Karlsson, Erika Roman, and Eva B. Brittebo

Long-term Cognitive Impairments in Adult Rats Treated Neonatally with β-N-Methylamino-L-Alanine
ToxSci Advance Access published on August 19, 2009
Toxicol. Sci. 2009 112: 185-195; doi:10.1093/toxsci/kfp196 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

RISK ASSESSMENT

Get checked abstract Bruce D. Naumann, Patricia A. Weideman, Ramesh Sarangapani, Shu-Cheih Hu, Rakesh Dixit, and Edward V. Sargent

Investigations of the Use of Bioavailability Data to Adjust Occupational Exposure Limits for Active Pharmaceutical Ingredients
ToxSci Advance Access published on August 19, 2009
Toxicol. Sci. 2009 112: 196-210; doi:10.1093/toxsci/kfp195 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kathy B. Baumgartner, Thomas J. Schlierf, Dongyan Yang, Mark A. Doll, and David W. Hein

N-acetyltransferase 2 Genotype Modification of Active Cigarette Smoking on Breast Cancer Risk among Hispanic and Non-Hispanic White Women
ToxSci Advance Access published on August 19, 2009
Toxicol. Sci. 2009 112: 211-220; doi:10.1093/toxsci/kfp199 [Abstract] [Full Text] [PDF] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Lyle D. Burgoon, Qi Ding, Alhaji N'jai, Ed Dere, Ashley R. Burg, J. Craig Rowlands, Robert A. Budinsky, Kenneth E. Stebbins, and Tim R. Zacharewski

Automated Dose-Response Analysis of the Relative Hepatic Gene Expression Potency of TCDF in C57BL/6 Mice
ToxSci Advance Access published on August 12, 2009
Toxicol. Sci. 2009 112: 221-228; doi:10.1093/toxsci/kfp180 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Suntae Kim, Edward Dere, Lyle D. Burgoon, Chia-Cheng Chang, and Timothy R. Zacharewski

Comparative Analysis of AhR-Mediated TCDD-Elicited Gene Expression in Human Liver Adult Stem Cells
ToxSci Advance Access published on August 14, 2009
Toxicol. Sci. 2009 112: 229-244; doi:10.1093/toxsci/kfp189 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Erik A. Carlson, Colin McCulloch, Aruna Koganti, Shirlean B. Goodwin, Thomas R. Sutter, and Jay B. Silkworth

Divergent Transcriptomic Responses to Aryl Hydrocarbon Receptor Agonists between Rat and Human Primary Hepatocytes
ToxSci Advance Access published on August 19, 2009
Toxicol. Sci. 2009 112: 257-272; doi:10.1093/toxsci/kfp200 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

COVER

COVER
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp261 [PDF] [Request Permissions]  

STANDING MATERIAL

Editorial Board
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp262 [PDF] [Request Permissions]  

CONTENTS
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp260 [PDF] [Request Permissions]  

SUBSCRIPTIONS
Toxicol. Sci. 2009 112: NP; doi:10.1093/toxsci/kfp263 [PDF] [Request Permissions]  

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