Toxicological Sciences

FORUM:

John Higginson

The International Agency for Research on Cancer: A Brief Review of Its History, Mission, and Program
Toxicol. Sci. 1998 43: 79-85; doi:10.1093/toxsci/43.2.79 [PDF] [Request Permissions]  

Iain F. H. Purchase, Philip A. Botham, Leon H. Bruner, Oliver P. Flint, John M. Frazier, and William S. Stokes

Workshop Overview: Scientific and Regulatory Challenges for the Reduction, Refinement, and Replacement of Animals in Toxicity Testing
Toxicol. Sci. 1998 43: 86-101; doi:10.1093/toxsci/43.2.86 [Abstract] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Joe L. Nieusma, David J. Claffey, James A. Ruth, and David Ross

Stereochemical Aspects of the Conjugation of Epoxide Metabolites of Butadiene with Glutathione in Rat Liver Cytosol and Freshly Isolated Rat Hepatocytes
Toxicol. Sci. 1998 43: 102-109; doi:10.1093/toxsci/43.2.102 [Abstract] [PDF] [Request Permissions]  

Richard A. Parent, Douglas E. Paust, Margaret K. Schrimpf, Rasmy E. Talaat, Rebecca A. Doane, Halina E. Caravello, Sung J. Lee, and Dale E. Sharp

Metabolism and Distribution of [2,3-¹⁴C]Acrolein in Sprague-Dawley Rats: II. Identification of Urinary and Fecal Metabolites
Toxicol. Sci. 1998 43: 110-120; doi:10.1093/toxsci/43.2.110 [Abstract] [PDF] [Request Permissions]  

Nahum Allon, Lily Raveh, Eran Gilat, Ephraim Cohen, Jacob Grunwald, and Yacov Ashani

Prophylaxis against Soman Inhalation Toxicity in Guinea Pigs by Pretreatment Alone with Human Serum Butyrylcholinesterase
Toxicol. Sci. 1998 43: 121-128; doi:10.1093/toxsci/43.2.121 [Abstract] [PDF] [Request Permissions]  

Carcinogenicity:

Y. P. Dragan, R. J. Shimel, N. Bahunb, G. Sattler, J. R. Vaughan, V. C. Jordan, and H. C. Pitot

Effect of Chronic Administration of Mestranol, Tamoxifen, and Toremifene on Hepatic Ploidy in Rats
Toxicol. Sci. 1998 43: 129-138; doi:10.1093/toxsci/43.2.129 [Abstract] [PDF] [Request Permissions]  

Lianhui Tao, Paula M. Kramer, Rongrong Ge, and Michael A. Pereira

Effect of Dichloroacetic Acid and Trichloroacetic Acid on DNA Methylation in Liver and Tumors of Female B6C3F1 Mice
Toxicol. Sci. 1998 43: 139-144; doi:10.1093/toxsci/43.2.139 [Abstract] [PDF] [Request Permissions]  

Stephen R. Channel, John R. Latendresse, Jay K. Kidney, John H. Grabau, John W. Lane, Linda Steel-Goodwin, and Matthew C. Gothaus

A Subchronic Exposure to Trichloroethylene Causes Lipid Peroxidation and Hepatocellular Proliferation in Male B6C3F1 Mouse Liver
Toxicol. Sci. 1998 43: 145-154; doi:10.1093/toxsci/43.2.145 [Abstract] [PDF] [Request Permissions]  

Environmental Toxicology:

Joanna Burger

Effects of Lead on Sibling Recognition in Young Herring Gulls
Toxicol. Sci. 1998 43: 155-160; doi:10.1093/toxsci/43.2.155 [Abstract] [PDF] [Request Permissions]  

H. T. Besselink, M. S. Denison, M. E. Hahn, S. I. Karchner, A. D. Vethaak, J. H. Koeman, and A. Brouwer

Low Inducibility of CYP1A Activity by Polychlorinated Biphenyls (PCBs) in Flounder (Platichthys flesus): Characterization of the Ah Receptor and the Role of CYP1A Inhibition
Toxicol. Sci. 1998 43: 161-171; doi:10.1093/toxsci/43.2.161 [Abstract] [PDF] [Request Permissions]  

Immunotoxicology:

Yong Heo, William T. Lee, and David A. Lawrence

Differential Effects of Lead and cAMP on Development and Activities of Th1- and Th2-Lymphocytes
Toxicol. Sci. 1998 43: 172-185; doi:10.1093/toxsci/43.2.172 [Abstract] [PDF] [Request Permissions]  

Neurotoxicology:

Vemin A. Benignus, William K. Boyes, and Philip J. Bushnell

A Dosimetric Analysis of Behavioral Effects of Acute Toluene Exposure in Rats and Humans
Toxicol. Sci. 1998 43: 186-195; doi:10.1093/toxsci/43.2.186 [Abstract] [PDF] [Request Permissions]  

Respiratory Toxicology:

Jonas Tallkvist, Jörgen Henriksson, Roland d'Argy, and Hans Tjälve

Transport and Subcellular Distribution of Nickel in the Olfactory System of Pikes and Rats
Toxicol. Sci. 1998 43: 196-203; doi:10.1093/toxsci/43.2.196 [Abstract] [PDF] [Request Permissions]  

Urmila P. Kodavanti, Russ Hauser, David C. Christiani, Zhi H. Meng, John McGee, Allen Ledbetter, Judy Richards, and Daniel L. Costa

Pulmonary Responses to Oil Fly Ash Particles in the Rat Differ by Virtue of Their Specific Soluble Metals
Toxicol. Sci. 1998 43: 204-212; doi:10.1093/toxsci/43.2.204 [Abstract] [PDF] [Request Permissions]  

Risk Assessment:

Lynne T. Haber, Bruce C. Allen, and Carole A. Kimmel

Non-Cancer Risk Assessment for Nickel Compounds: Issues Associated with Dose-Response Modeling of Inhalation and Oral Exposures
Toxicol. Sci. 1998 43: 213-229; doi:10.1093/toxsci/43.2.213 [Abstract] [PDF] [Request Permissions]  

Safety Evaluation:

Leigh Ann Burns-Naas, Richard W. Mast, Robert G. Meeks, Peter C. Mann, and Philippe Thevenaz

Inhalation Toxicology of Decamethylcyclopentasiloxane (D₅) Following a 3-Month Nose-Only Exposure in Fischer 344 Rats
Toxicol. Sci. 1998 43: 230-240; doi:10.1093/toxsci/43.2.230 [Abstract] [PDF] [Request Permissions]  

Systems Toxicology:

R. C. A. Hermanns, L. L. de Zwart, P. J. M. Salemink, J. N. M. Commandeur, N. P. E. Vermeulen, and J. H. N. Meerman

Urinary Excretion of Biomarkers of Oxidative Kidney Damage Induced by Ferric Nitrilotriacetate
Toxicol. Sci. 1998 43: 241-249; doi:10.1093/toxsci/43.2.241 [Abstract] [PDF] [Request Permissions]  

AUTHOR INDEX FOR VOLUME 43:

Author Index for Volume 43
Toxicol. Sci. 1998 43: 250; doi:10.1093/toxsci/43.2.250 [PDF] [Request Permissions]  

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