Toxicological Sciences

Biotransformation and Toxicokinetics:

Sean K. Kelley, Charlotte B. Nilsson, Michael H. Green, Joanne Balrner Green, and Helen Håkansson

Use of Model-Based Compartmental Analysis to Study Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Vitamin A Kinetics in Rats
Toxicol. Sci. 1998 44: 1-13; doi:10.1093/toxsci/44.1.1 [Abstract] [PDF] [Request Permissions]  

James M. Mathews, Amy S. Etheridge, and H. B. Matthews

HIGHLIGHT: Dose-Dependent Metabolism of Benzene in Hamsters, Rats, and Mice
Toxicol. Sci. 1998 44: 14-21; doi:10.1093/toxsci/44.1.14 [Abstract] [PDF] [Request Permissions]  

Carcinogenicity:

Craig S. Nessel, Robert A. J. Priston, Richard H. McKee, George Cruzan, Anthony J. Riley, Hagemann Randi, Robert T. Plutnick, and Barry J. Simpson

A Comprehensive Evaluation of the Mechanism of Skin Tumorigenesis by Straight-Run and Cracked Petroleum Middle Distillates
Toxicol. Sci. 1998 44: 22-31; doi:10.1093/toxsci/44.1.22 [Abstract] [PDF] [Request Permissions]  

Immunotoxicology:

Mario Governa, Lamberto Camilucci, Monica Amati, Isabella Visonà, Matteo Valentino, Gian Carlo Botta, Antonella Campopiano, and Carla Fanizza

Wollastonite Fibers in Vitro Generate Reactive Oxygen Species Able to Lyse Erythrocytes and Activate the Complement Alternate Pathway
Toxicol. Sci. 1998 44: 32-38; doi:10.1093/toxsci/44.1.32 [Abstract] [PDF] [Request Permissions]  

E. H. M. van't Erve, E. Wijnand, M. Bol, W. Seinen, and R. H. H. Pieters

The Vehicle Modulates Cellular and Humoral Responses in Contact Hypersensitivity to Oxazolone
Toxicol. Sci. 1998 44: 39-45; doi:10.1093/toxsci/44.1.39 [Abstract] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

Philip Carthew, Richard E. Edwards, and Barbara M. Nolan

The Quantitative Distinction of Hyperplasia from Hypertrophy in Hepatomegaly Induced in the Rat Liver by Phenobarbital
Toxicol. Sci. 1998 44: 46-51; doi:10.1093/toxsci/44.1.46 [Abstract] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

Dennis E. Sawyer, Gilbert R. Hillman, Tatsuo Uchida, and David B. Brown

Altered Nuclear Activation Parameters of Rat Sperm Treated in Vitro with Chromatin-Damaging Agents
Toxicol. Sci. 1998 44: 52-62; doi:10.1093/toxsci/44.1.52 [Abstract] [PDF] [Request Permissions]  

Respiratory Toxicology:

Wumin Dong, M. Ian Gilmour, Amy L. Lambert, and MaryJane K. Selgrade

Enhanced Allergic Responses to House Dust Mite by Oral Exposure to Carbaryl in Rats
Toxicol. Sci. 1998 44: 63-69; doi:10.1093/toxsci/44.1.63 [Abstract] [PDF] [Request Permissions]  

Takamichi Ichinose, Hirohisa Takano, Yuichi Miyabara, and Masaru Sagai

Long-Term Exposure to Diesel Exhaust Enhances Antigen-Induced Eosinophilic Inflammation and Epithelial Damage in the Murine Airway
Toxicol. Sci. 1998 44: 70-79; doi:10.1093/toxsci/44.1.70 [Abstract] [PDF] [Request Permissions]  

Bahman Asgharian and Satish Anjilvel

A Multiple-Path Model of Fiber Deposition in the Rat Lung
Toxicol. Sci. 1998 44: 80-86; doi:10.1093/toxsci/44.1.80 [Abstract] [PDF] [Request Permissions]  

Safety Evaluation:

Philip F. Solter, Gordon K. Wollenberg, Xuan Huang, Fun S. Chu, and Maria T. Runnegar

Prolonged Sublethal Exposure to the Protein Phosphatase Inhibitor Microcystin-LR Results in Multiple Dose-Dependent Hepatotoxic Effects
Toxicol. Sci. 1998 44: 87-96; doi:10.1093/toxsci/44.1.87 [Abstract] [PDF] [Request Permissions]  

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