Toxicological Sciences

Articles:

JJ DeGeorge, LL Meyers, M Takahashi, and JF Contrera

The duration of non-rodent toxicity studies for pharmaceuticals. International Conference on Harmonication (ICH)
Toxicol. Sci. 1999 49: 143-155; doi:10.1093/toxsci/49.2.143 [Abstract] [PDF] [Request Permissions]  

DL Eaton and TK Bammler

Concise review of the glutathione S-transferases and their significance to toxicology
Toxicol. Sci. 1999 49: 156-164; doi:10.1093/toxsci/49.2.156 [PDF] [Request Permissions]  

PG Watanabe

An observation: role of the M.D., Ph.D. in science
Toxicol. Sci. 1999 49: 165; doi:10.1093/toxsci/49.2.165 [PDF] [Request Permissions]  

JM Rice, RA Baan, M Blettner, C Genevois-Charmeau, Y Grosse, DB McGregor, C Partensky, and JD Wilbourn

Rodent tumors of urinary bladder, renal cortex, and thyroid gland in IARC Monographs evaluations of carcinogenic risk to humans
Toxicol. Sci. 1999 49: 166-171; doi:10.1093/toxsci/49.2.166 [PDF] [Request Permissions]  

DA Keys, DG Wallace, TB Kepler, and RB Conolly

Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats [published erratum appears in Toxicol Sci 1999 Nov;52(1):140]
Toxicol. Sci. 1999 49: 172-185; doi:10.1093/toxsci/49.2.172 [Abstract] [PDF] [Request Permissions]  

KA Richardson, MM Peters, BA Wong, RH Megens, PA van Elburg, ED Booth, PJ Boogaard, JA Bond, MA Medinsky, WP Watson, and NJ van Sittert

Quantitative and qualitative differences in the metabolism of 14C-1,3- butadiene in rats and mice: relevance to cancer susceptibility
Toxicol. Sci. 1999 49: 186-201; doi:10.1093/toxsci/49.2.186 [Abstract] [PDF] [Request Permissions]  

BA Wetmore, AD Mitchell, SA Meyer, and MB Genter

Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat
Toxicol. Sci. 1999 49: 202-212; doi:10.1093/toxsci/49.2.202 [Abstract] [PDF] [Request Permissions]  

FY Bois, TJ Smith, A Gelman, HY Chang, and AE Smith

Optimal design for a study of butadiene toxicokinetics in humans
Toxicol. Sci. 1999 49: 213-224; doi:10.1093/toxsci/49.2.213 [Abstract] [PDF] [Request Permissions]  

JJ Stanek and JB Morris

The effect of inhibition of aldehyde dehydrogenase on nasal uptake of inspired acetaldehyde
Toxicol. Sci. 1999 49: 225-231; doi:10.1093/toxsci/49.2.225 [Abstract] [PDF] [Request Permissions]  

AM Rummel, JE Trosko, MR Wilson, and BL Upham

Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity
Toxicol. Sci. 1999 49: 232-240; doi:10.1093/toxsci/49.2.232 [Abstract] [PDF] [Request Permissions]  

JW Spalding, JE French, RR Tice, M Furedi-Machacek, JK Haseman, and RW Tennant

Development of a transgenic mouse model for carcinogenesis bioassays: evaluation of chemically induced skin tumors in Tg.AC mice
Toxicol. Sci. 1999 49: 241-254; doi:10.1093/toxsci/49.2.241 [Abstract] [PDF] [Request Permissions]  

PS Samiec and JI Goodman

Evaluation of methylated DNA binding protein-1 in mouse liver
Toxicol. Sci. 1999 49: 255-262; doi:10.1093/toxsci/49.2.255 [Abstract] [PDF] [Request Permissions]  

A Hood, YP Liu, VH Gattone, 2nd, and CD Klaassen

Sensitivity of thyroid gland growth to thyroid stimulating hormone (TSH) in rats treated with antithyroid drugs
Toxicol. Sci. 1999 49: 263-271; doi:10.1093/toxsci/49.2.263 [Abstract] [PDF] [Request Permissions]  

SB Pruett, S Collier, WJ Wu, and R Fan

Quantitative relationships between the suppression of selected immunological parameters and the area under the corticosterone concentration vs. time curve in B6C3F1 mice subjected to exogenous corticosterone or to restraint stress
Toxicol. Sci. 1999 49: 272-280; doi:10.1093/toxsci/49.2.272 [Abstract] [PDF] [Request Permissions]  

MG Aguilar-Gonzalez, A Hernandez, ML Lopez, T Mendoza-Figueroa, and A Albores

Arsenite alters heme synthesis in long-term cultures of adult rat hepatocytes
Toxicol. Sci. 1999 49: 281-289; doi:10.1093/toxsci/49.2.281 [Abstract] [PDF] [Request Permissions]  

M Shibata, T Hariya, M Hatao, T Ashikaga, and H Ichikawa

Quantitative polymerase chain reaction using an external control mRNA for determination of gene expression in a heterogeneous cell population
Toxicol. Sci. 1999 49: 290-296; doi:10.1093/toxsci/49.2.290 [Abstract] [PDF] [Request Permissions]  

K Haidara, P Moffatt, and F Denizeau

Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes
Toxicol. Sci. 1999 49: 297-305; doi:10.1093/toxsci/49.2.297 [Abstract] [PDF] [Request Permissions]  

LA Chaney, RW Rockhold, RW Wineman, and AS Hume

Anticonvulsant-resistant seizures following pyridostigmine bromide (PB) and N,N-diethyl-m-toluamide (DEET)
Toxicol. Sci. 1999 49: 306-311; doi:10.1093/toxsci/49.2.306 [Abstract] [PDF] [Request Permissions]  

R Tardif and G Charest-Tardif

The importance of measured end-points in demonstrating the occurrence of interactions: a case study with methylchloroform and m-xylene
Toxicol. Sci. 1999 49: 312-317; doi:10.1093/toxsci/49.2.312 [Abstract] [PDF] [Request Permissions]  

DW Gaylor and RL Kodell

Dose-response trend tests for tumorigenesis, adjusted for body weight
Toxicol. Sci. 1999 49: 318-323; doi:10.1093/toxsci/49.2.318 [Abstract] [PDF] [Request Permissions]  

N Sagara-Ishijima and K Furuhama

Toxic characteristics of the synthetic lipid A derivative DT-5461 in rats and monkeys
Toxicol. Sci. 1999 49: 324-331; doi:10.1093/toxsci/49.2.324 [Abstract] [PDF] [Request Permissions]  

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