Toxicological Sciences

Editorials:

Curtis D. Klaassen and Hanspeter Witschi

Profiles in Toxicology
Toxicol. Sci. 2000 53: 1; doi:10.1093/toxsci/53.1.1 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Profiles in Toxicology:

Joseph F. Borzelleca

Paracelsus: Herald of Modern Toxicology
Toxicol. Sci. 2000 53: 2-4; doi:10.1093/toxsci/53.1.2 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Aqel W. Abu-Qare, Ali A. Abdel-Rahman, Amal M. Kishk, and Mohamed B. Abou-Donia

Placental Transfer and Pharmacokinetics of a Single Dermal Dose of [¹⁴C]Methyl Parathion in Rats
Toxicol. Sci. 2000 53: 5-12; doi:10.1093/toxsci/53.1.5 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

R. A. Corley, S. M. Gordon, and L. A. Wallace

Physiologically Based Pharmacokinetic Modeling of the Temperature-Dependent Dermal Absorption of Chloroform by Humans following Bath Water Exposures
Toxicol. Sci. 2000 53: 13-23; doi:10.1093/toxsci/53.1.13 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kai Blumbach, Axel Pähler, H. M. Deger, and Wolfgang Dekant

Biotransformation and Male Rat-Specific Renal Toxicity of Diethyl Ethyl- and Dimethyl Methylphosphonate
Toxicol. Sci. 2000 53: 24-32; doi:10.1093/toxsci/53.1.24 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

S. Takayama, A. G. Renwick, S. L. Johansson, U. P. Thorgeirsson, M. Tsutsumi, D. W. Dalgard, and S. M. Sieber

Long-Term Toxicity and Carcinogenicity Study of Cyclamate in Nonhuman Primates
Toxicol. Sci. 2000 53: 33-39; doi:10.1093/toxsci/53.1.33 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

Patricia K. Tithof, Jesus Olivero, Kirsten Ruehle, and Patricia E. Ganey

Activation of Neutrophil Calcium-Dependent and -Independent Phospholipases A₂ by Organochlorine Compounds
Toxicol. Sci. 2000 53: 40-47; doi:10.1093/toxsci/53.1.40 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

M. A. Davis, J. A. Flaws, M. Young, K. Collins, and N. H. Colburn

Effect of Ceramide on Intracellular Glutathione Determines Apoptotic or Necrotic Cell Death of JB6 Tumor Cells
Toxicol. Sci. 2000 53: 48-55; doi:10.1093/toxsci/53.1.48 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. A. Tirmenstein, F. A. Nicholls-Grzemski, T. D. Schmittgen, B. A. Zakrajsek, and M. W. Fariss

Characterization of Nitric Oxide Production following Isolation of Rat Hepatocytes
Toxicol. Sci. 2000 53: 56-62; doi:10.1093/toxsci/53.1.56 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

Thomas L. Wallace, Christina Gamba-Vitalo, Ken S. Loveday, and Paul A. Cossum

Acute, Multiple-Dose, and Genetic Toxicology of AR177, an Anti-HIV Oligonucleotide
Toxicol. Sci. 2000 53: 63-70; doi:10.1093/toxsci/53.1.63 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Martelli, L. Robbiano, R. Carrozzino, C. Porta Puglia, F. Mattioli, M. Angiola, and G. Brambilla

DNA Damage Induced by 3,3'-Dimethoxybenzidine in Liver and Urinary Bladder Cells of Rats and Humans
Toxicol. Sci. 2000 53: 71-76; doi:10.1093/toxsci/53.1.71 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shyam S. Biswal, Kaushik Datta, Stephanie D. Shaw, Xiang Feng, John D. Robertson, and James P. Kehrer

Glutathione Oxidation and Mitochondrial Depolarization as Mechanisms of Nordihydroguaiaretic Acid-Induced Apoptosis in Lipoxygenase-Deficient FL5.12 Cells
Toxicol. Sci. 2000 53: 77-83; doi:10.1093/toxsci/53.1.77 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

I. H. C. H. M. Philippens, R. A. P. Vanwersch, B. Groen, B. Olivier, P. L. B. Bruijnzeel, and B. P. C. Melchers

Subchronic Physostigmine Pretreatment in Marmosets: Absence of Side Effects and Effectiveness against Soman Poisoning with Negligible Postintoxication Incapacitation
Toxicol. Sci. 2000 53: 84-91; doi:10.1093/toxsci/53.1.84 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Narender Kumar, Toyin Savage, William DeJesus, Y. Y. Tsong, A. Didolkar, and K. Sundaram

Chronic Toxicity and Reversibility of Antifertility Effect of Immunization against Gonadotropin-Releasing Hormone in Male Rats and Rabbits
Toxicol. Sci. 2000 53: 92; doi:10.1093/toxsci/53.1.92 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Thomas R. Hanley, Jr., Edward W. Carney, and E. Marshall Johnson

Developmental Toxicity Studies in Rats and Rabbits with 3,5,6-Trichloro-2-pyridinol, the Major Metabolite of Chlorpyrifos
Toxicol. Sci. 2000 53: 100-108; doi:10.1093/toxsci/53.1.100 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Angelique S. Boyer, Wendy T. Finch, and Raymond B. Runyan

Trichloroethylene Inhibits Development of Embryonic Heart Valve Precursors in Vitro
Toxicol. Sci. 2000 53: 109-117; doi:10.1093/toxsci/53.1.109 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Keith W. Ward, Ellen H. Rogers, and E. Sidney Hunter, III

Comparative Pathogenesis of Haloacetic Acid and Protein Kinase Inhibitor Embryotoxicity in Mouse Whole Embryo Culture
Toxicol. Sci. 2000 53: 118-121; doi:10.1093/toxsci/53.1.118 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Simon J. Rothenberg, Robert M. Parker, Raymond G. York, George E. Dearlove, Margaret M. Martin, Kevin H. Denny, Stephen D. Lief, Alan M. Hoberman, and Mildred S. Christian

Lack of Effects of Nose-Only Inhalation Exposure on Testicular Toxicity in Male Rats
Toxicol. Sci. 2000 53: 127-134; doi:10.1093/toxsci/53.1.127 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Barry L. Yano, John T. Young, and Joel L. Mattsson

Lack of Carcinogenicity of Chlorpyrifos Insecticide in a High-Dose, 2-Year Dietary Toxicity Study in Fischer 344 Rats
Toxicol. Sci. 2000 53: 135-144; doi:10.1093/toxsci/53.1.135 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

T. Thomas, F. Rauscher, R. Sanders, J. Veltman, and J. B. Watkins, III

Effects of Aldose Reductase Inhibitors on Antioxidant Defense in Rat and Rabbit Liver
Toxicol. Sci. 2000 53: 145-149; doi:10.1093/toxsci/53.1.145 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alexandra B. Duguay, Ibrahim M. Yousef, and Gabriel L. Plaa

Manganese-Bilirubin Effect on Cholesterol Accumulation in Rat Bile Canalicular Membranes
Toxicol. Sci. 2000 53: 150-155; doi:10.1093/toxsci/53.1.150 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Letters to the Editor:

Russell A. Wilke

LETTER TO THE EDITOR
Toxicol. Sci. 2000 53: 156; doi:10.1093/toxsci/53.1.156 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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