Toxicological Sciences

Profiles in Toxicology:

Paul E. Morrow, Hanspeter Witschi, M. Vore, P. E. Hakkinen, Judith MacGregor, James MacGregor, Marion W. Anders, and Calvin Willhite

Harold Carpenter Hodge (1904–1990)
Toxicol. Sci. 2000 53: 157-158; doi:10.1093/toxsci/53.2.157 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

Melvin E. Andersen, M. Elizabeth Meek, Gary A. Boorman, David J. Brusick, Samuel M. Cohen, Yvonne P. Dragan, Clay B. Frederick, Jay I. Goodman, Gordon C. Hard, Ellen J. O'Flaherty, and Denise E. Robinson

Lessons Learned in Applying the U.S. EPA Proposed Cancer Guidelines to Specific Compounds
Toxicol. Sci. 2000 53: 159-172; doi:10.1093/toxsci/53.2.159 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Deborah A. Keys, Duncan G. Wallace, Thomas B. Kepler, and Rory B. Conolly

Quantitative Evaluation of Alternative Mechanisms of Blood Disposition of Di(n-butyl) Phthalate and Mono(n-butyl) Phthalate in Rats
Toxicol. Sci. 2000 53: 173-184; doi:10.1093/toxsci/53.2.173 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey W. Fisher, David C. Dorman, Michelle A. Medinsky, Frank Welsch, and Rory B. Conolly

Analysis of Respiratory Exchange of Methanol in the Lung of the Monkey Using a Physiological Model
Toxicol. Sci. 2000 53: 185-193; doi:10.1093/toxsci/53.2.185 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alexander Amberg, Elisabeth Rosner, and Wolfgang Dekant

Biotransformation and Kinetics of Excretion of Ethyl tert-Butyl Ether in Rats and Humans
Toxicol. Sci. 2000 53: 194-201; doi:10.1093/toxsci/53.2.194 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vijaya M. Lakshmi, Fong Fu Hsu, Alaine E. McGarry, Bernard B. Davis, and Terry V. Zenser

Hypochlorous Acid-Mediated Activation of N-acetylbenzidine to Form N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine
Toxicol. Sci. 2000 53: 202-212; doi:10.1093/toxsci/53.2.202 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Judson W. Spalding, John E. French, Stanley Stasiewicz, Marianna Furedi-Machacek, Fawn Conner, Raymond R. Tice, and Raymond W. Tennant

Responses of Transgenic Mouse Lines p53^+/- and Tg•AC to Agents Tested in Conventional Carcinogenicity Bioassays
Toxicol. Sci. 2000 53: 213-223; doi:10.1093/toxsci/53.2.213 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Matthew K. Ross, Boctor Said, and Ronald C. Shank

DNA-Damaging Effects of Genotoxins in Mixture: Modulation of Covalent Binding to DNA
Toxicol. Sci. 2000 53: 224-236; doi:10.1093/toxsci/53.2.224 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Gordon C. Hard, Gary A. Boorman, and Douglas C. Wolf

Re-evaluation of the 2-Year Chloroform Drinking Water Carcinogenicity Bioassay in Osborne-Mendel Rats Supports Chronic Renal Tubule Injury as the Mode of Action Underlying the Renal Tumor Response
Toxicol. Sci. 2000 53: 237-244; doi:10.1093/toxsci/53.2.237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Daniel L. Gustafson, Michael E. Long, Russell S. Thomas, Stephen A. Benjamin, and Raymond S. H. Yang

Comparative Hepatocarcinogenicity of Hexachlorobenzene, Pentachlorobenzene, 1,2,4,5-Tetrachlorobenzene, and 1,4-Dichlorobenzene: Application of a Medium-Term Liver Focus Bioassay and Molecular and Cellular Indices
Toxicol. Sci. 2000 53: 245-252; doi:10.1093/toxsci/53.2.245 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hui-Ren Zhou, Jack R. Harkema, Jon A. Hotchkiss, Ding Yan, Robert A. Roth, and James J. Pestka

Lipopolysaccharide and the Trichothecene Vomitoxin (Deoxynivalenol) Synergistically Induce Apoptosis in Murine Lymphoid Organs
Toxicol. Sci. 2000 53: 253-263; doi:10.1093/toxsci/53.2.253 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Rola Barhoumi, Youssef Mouneimne, Kenneth S. Ramos, Stephen H. Safe, Timothy D. Phillips, Victoria E. Centonze, Clay Ainley, Mona S. Gupta, and Robert C. Burghardt

Analysis of Benzo[a]pyrene Partitioning and Cellular Homeostasis in a Rat Liver Cell Line
Toxicol. Sci. 2000 53: 264-270; doi:10.1093/toxsci/53.2.264 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Dörrenhaus, A. Flieger, K. Golka, H. Schulze, M. Albrecht, G. H. Degen, and W. Föllmann

Induction of Unscheduled DNA Synthesis in Primary Human Urothelial Cells by the Mycotoxin Ochratoxin A
Toxicol. Sci. 2000 53: 271-277; doi:10.1093/toxsci/53.2.271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

Timothy J. Schrader and Gerard M. Cooke

Examination of Selected Food Additives and Organochlorine Food Contaminants for Androgenic Activity in Vitro
Toxicol. Sci. 2000 53: 278-288; doi:10.1093/toxsci/53.2.278 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tomoya Yamada, Takeshi Kunimatsu, Hiroshi Sako, Setsuko Yabushita, Tokuo Sukata, Yasuyoshi Okuno, and Masatoshi Matsuo

Comparative Evaluation of a 5-Day Hershberger Assay Utilizing Mature Male Rats and a Pubertal Male Assay for Detection of Flutamide's Antiandrogenic Activity
Toxicol. Sci. 2000 53: 289-296; doi:10.1093/toxsci/53.2.289 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ralph L. Cooper, Tammy E. Stoker, Lee Tyrey, Jerome M. Goldman, and W. Keith McElroy

Atrazine Disrupts the Hypothalamic Control of Pituitary-Ovarian Function
Toxicol. Sci. 2000 53: 297-307; doi:10.1093/toxsci/53.2.297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

Everett J. Perkins, Jr. and Dan Schlenk

In Vivo Acetylcholinesterase Inhibition, Metabolism, and Toxicokinetics of Aldicarb in Channel Catfish: Role of Biotransformation in Acute Toxicity
Toxicol. Sci. 2000 53: 308-315; doi:10.1093/toxsci/53.2.308 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Eli V. Hestermann, John J. Stegeman, and Mark E. Hahn

Serum Alters the Uptake and Relative Potencies of Halogenated Aromatic Hydrocarbons in Cell Culture Bioassays
Toxicol. Sci. 2000 53: 316-325; doi:10.1093/toxsci/53.2.316 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jason Matthews and Tim Zacharewski

Differential Binding Affinities of PCBs, HO-PCBs, and Aroclors with Recombinant Human, Rainbow Trout (Onchorhynkiss mykiss), and Green Anole (Anolis carolinensis) Estrogen Receptors, Using a Semi-High Throughput Competitive Binding Assay
Toxicol. Sci. 2000 53: 326-339; doi:10.1093/toxsci/53.2.326 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

Jason S. Isenberg and James E. Klaunig

Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells
Toxicol. Sci. 2000 53: 340-351; doi:10.1093/toxsci/53.2.340 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jessica F. Greene, Jiang Zheng, David F. Grant, and Bruce D. Hammock

Cytotoxicity of 1,2-epoxynaphthalene Is Correlated with Protein Binding and in Situ Glutathione Depletion in Cytochrome P4501A1 Expressing Sf-21 Cells
Toxicol. Sci. 2000 53: 352-360; doi:10.1093/toxsci/53.2.352 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

Masato Matsuoka, Bambang Wispriyono, Yoshihisa Iryo, and Hideki Igisu

Mercury Chloride Activates c-Jun N-Terminal Kinase and Induces c-jun Expression in LLC-PK₁ Cells
Toxicol. Sci. 2000 53: 361-368; doi:10.1093/toxsci/53.2.361 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Guan-Jun Wang and Lu Cai

Induction of Cell-Proliferation Hormesis and Cell-Survival Adaptive Response in Mouse Hematopoietic Cells by Whole-Body Low-Dose Radiation
Toxicol. Sci. 2000 53: 369-376; doi:10.1093/toxsci/53.2.369 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

G. B. Freeman, R. A. Lordo, A. W. Singer, A. C. Peters, B. H. Neal, E. E. McConnell, and B. A. Mayes

An Assessment of Neurotoxicity of Aroclors 1016, 1242, 1254, and 1260 Administered in Diet to Sprague-Dawley Rats for One Year
Toxicol. Sci. 2000 53: 377-391; doi:10.1093/toxsci/53.2.377 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Takahide Kihara, Takuya Matsuo, Michiko Sakamoto, Yoshiko Yasuda, Yoshitame Yamamoto, and Takashi Tanimura

Effects of Prenatal Aflatoxin B₁ Exposure on Behaviors of Rat Offspring
Toxicol. Sci. 2000 53: 392-399; doi:10.1093/toxsci/53.2.392 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James W. Crissman, Paul S. Cooke, Rex A. Hess, M. Sue Marty, and Ashley B. Liberacki

Postulated Human Sperm Count Decline May Involve Historic Elimination of Juvenile Iodine Deficiency: A New Hypothesis with Experimental Evidence in the Rat
Toxicol. Sci. 2000 53: 400-410; doi:10.1093/toxsci/53.2.400 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Christopher H. Hurst, Michael J. DeVito, R. Woodrow Setzer, and Linda S. Birnbaum

Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Pregnant Long Evans Rats: Association of Measured Tissue Concentrations with Developmental Effects
Toxicol. Sci. 2000 53: 411-420; doi:10.1093/toxsci/53.2.411 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey L. Larson, Thomas L. Wallace, Rochelle W. Tyl, Melissa C. Marr, Christina B. Myers, and Paul A. Cossum

The Reproductive and Developmental Toxicity of the Antifungal Drug Nyotran® (Liposomal Nystatin) in Rats and Rabbits
Toxicol. Sci. 2000 53: 421-429; doi:10.1093/toxsci/53.2.421 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

Werner Hofmann, Bahman Asgharian, Ralph Bergmann, Satish Anjilvel, and Fred J. Miller

The Effect of Heterogeneity of Lung Structure on Particle Deposition in the Rat Lung
Toxicol. Sci. 2000 53: 430-437; doi:10.1093/toxsci/53.2.430 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Joel L. Mattsson, Jacques P. J. Maurissen, Richard J. Nolan, and Kathy A. Brzak

Lack of Differential Sensitivity to Cholinesterase Inhibition in Fetuses and Neonates Compared to Dams Treated Perinatally with Chlorpyrifos
Toxicol. Sci. 2000 53: 438-446; doi:10.1093/toxsci/53.2.438 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Peter L. Goering, Benjamin R. Fisher, Bradley T. Noren, Andriana Papaconstantinou, Jennifer L. Rojko, and Ronald J. Marler

Mercury Induces Regional and Cell-Specific Stress Protein Expression in Rat Kidney
Toxicol. Sci. 2000 53: 447-457; doi:10.1093/toxsci/53.2.447 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Brian S. Cummings and Lawrence H. Lash

Metabolism and Toxicity of Trichloroethylene and S-(1,2-Dichlorovinyl)-L-Cysteine in Freshly Isolated Human Proximal Tubular Cells
Toxicol. Sci. 2000 53: 458-466; doi:10.1093/toxsci/53.2.458 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jack A. Hinson, Sherryll L. Michael, Subrena G. Ault, and Neil R. Pumford

Western Blot Analysis for Nitrotyrosine Protein Adducts in Livers of Saline-Treated and Acetaminophen-Treated Mice
Toxicol. Sci. 2000 53: 467-473; doi:10.1093/toxsci/53.2.467 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Hideaki Shimada, Takayuki Funakoshi, and Michael P. Waalkes

Acute, Nontoxic Cadmium Exposure Inhibits Pancreatic Protease Activities in the Mouse
Toxicol. Sci. 2000 53: 474-480; doi:10.1093/toxsci/53.2.474 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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