Toxicological Sciences

Profiles in Toxicology:

John Doull

Kenneth Patrick DuBois (August 9, 1917–January 24, 1973)
Toxicol. Sci. 2000 54: 1-2; doi:10.1093/toxsci/54.1.1 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Lynn H. Pottenger, Jeanne Y. Domoradzki, Dan A. Markham, Steven C. Hansen, Stuart Z. Cagen, and John M. Waechter, Jr.

The Relative Bioavailability and Metabolism of Bisphenol A in Rats Is Dependent upon the Route of Administration
Toxicol. Sci. 2000 54: 3-18; doi:10.1093/toxsci/54.1.3 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kelly F. Windmill, Andrea Gaedigk, Pauline de la M. Hall, Hema Samaratunga, Denis M. Grant, and Michael E. McManus

Localization of N-Acetyltransferases NAT1 and NAT2 in Human Tissues
Toxicol. Sci. 2000 54: 19-29; doi:10.1093/toxsci/54.1.19 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Theo K. Bammler, Dennis H. Slone, and David L. Eaton

Effects of Dietary Oltipraz and Ethoxyquin on Aflatoxin B₁ Biotransformation in Non-Human Primates
Toxicol. Sci. 2000 54: 30-41; doi:10.1093/toxsci/54.1.30 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Torka S. Poet, Karla D. Thrall, Richard A. Corley, Xiaoying Hui, Jeff A. Edwards, Karl K. Weitz, Howard I. Maibach, and Ronald C. Wester

Utility of Real Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling to Determine the Percutaneous Absorption of Methyl Chloroform in Rats and Humans
Toxicol. Sci. 2000 54: 42-51; doi:10.1093/toxsci/54.1.42 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

P. S. Samiec, L. J. Dahm, and D. P. Jones

Glutathione S-Transferase in Mucus of Rat Small Intestine
Toxicol. Sci. 2000 54: 52-59; doi:10.1093/toxsci/54.1.52 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shakil A. Saghir, Larry G. Hansen, Kenneth R. Holmes, and Prasada R. S. Kodavanti

Differential and Non-Uniform Tissue and Brain Distribution of Two Distinct ¹⁴C-Hexachlorobiphenyls in Weanling Rats
Toxicol. Sci. 2000 54: 60-70; doi:10.1093/toxsci/54.1.60 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Marina Villafañe Evans and Melvin E. Andersen

Sensitivity Analysis of a Physiological Model for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Assessing the Impact of Specific Model Parameters on Sequestration in Liver and Fat in the Rat
Toxicol. Sci. 2000 54: 71-80; doi:10.1093/toxsci/54.1.71 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. Sierra-Santoyo, M. Hernández, A. Albores, and M. E. Cebrián

Sex-Dependent Regulation of Hepatic Cytochrome P-450 by DDT
Toxicol. Sci. 2000 54: 81-87; doi:10.1093/toxsci/54.1.81 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Melissa A. Troester, Andrew B. Lindstrom, Lawrence L. Kupper, Suramya Waidyanatha, and Stephen M. Rappaport

Stability of Hemoglobin and Albumin Adducts of Benzene Oxide and 1,4-Benzoquinone after Administration of Benzene to F344 Rats
Toxicol. Sci. 2000 54: 88-94; doi:10.1093/toxsci/54.1.88 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Niklas Finnberg, Ulla Stenius, and Johan Högberg

Xenobiotics Modulate the p53 Response to DNA Damage in Preneoplastic Enzyme-Altered Foci in Rat Liver; Effects of Diethylnitrosamine and Phenobarbital
Toxicol. Sci. 2000 54: 95-103; doi:10.1093/toxsci/54.1.95 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Shuji Tsuda, Naonori Matsusaka, Shunji Ueno, Nobuyuki Susa, and Yu F. Sasaki

The Influence of Antioxidants on Cigarette Smoke-Induced DNA Single-Strand Breaks in Mouse Organs: A Preliminary Study with the Alkaline Single Cell Gel Electrophoresis Assay
Toxicol. Sci. 2000 54: 104-109; doi:10.1093/toxsci/54.1.104 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael P. Waalkes, Sabine Rehm, and M. George Cherian

Repeated Cadmium Exposures Enhance the Malignant Progression of Ensuing Tumors in Rats
Toxicol. Sci. 2000 54: 110-120; doi:10.1093/toxsci/54.1.110 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

J. Thomas Sanderson, Willem Seinen, John P. Giesy, and Martin van den Berg

2-Chloro-s-Triazine Herbicides Induce Aromatase (CYP19) Activity in H295R Human Adrenocortical Carcinoma Cells: A Novel Mechanism for Estrogenicity?
Toxicol. Sci. 2000 54: 121-127; doi:10.1093/toxsci/54.1.121 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Vickie S. Wilson and Gerald A. LeBlanc

The Contribution of Hepatic Inactivation of Testosterone to the Lowering of Serum Testosterone Levels by Ketoconazole
Toxicol. Sci. 2000 54: 128-137; doi:10.1093/toxsci/54.1.128 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Robert M. Blair, Hong Fang, William S. Branham, Bruce S. Hass, Stacey L. Dial, Carrie L. Moland, Weida Tong, Leming Shi, Roger Perkins, and Daniel M. Sheehan

The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands
Toxicol. Sci. 2000 54: 138-153; doi:10.1093/toxsci/54.1.138 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Susan C. Laws, Stephan A. Carey, Janet M. Ferrell, Gerald J. Bodman, and Ralph L. Cooper

Estrogenic Activity of Octylphenol, Nonylphenol, Bisphenol A and Methoxychlor in Rats
Toxicol. Sci. 2000 54: 154-167; doi:10.1093/toxsci/54.1.154 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Tracy M. Williams, Russell C. Cattley, and Susan J. Borghoff

Alterations in Endocrine Responses in Male Sprague-Dawley Rats following Oral Administration of Methyl tert-Butyl Ether
Toxicol. Sci. 2000 54: 168-176; doi:10.1093/toxsci/54.1.168 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

Daniel Schlenk, William C. Colley, Abir El-Alfy, Richard Kirby, and Billy R. Griffin

Effects of the Oxidant Potassium Permanganate on the Expression of Gill Metallothionein mRNA and Its Relationship to Sublethal Whole Animal Endpoints in Channel Catfish
Toxicol. Sci. 2000 54: 177-182; doi:10.1093/toxsci/54.1.177 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Michael H. Ziccardi, Ian A. Gardner, and Michael S. Denison

Development and Modification of a Recombinant Cell Bioassay to Directly Detect Halogenated and Polycyclic Aromatic Hydrocarbons in Serum
Toxicol. Sci. 2000 54: 183-193; doi:10.1093/toxsci/54.1.183 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

Xiaoming Zhou, Aiping Zhao, Gertrud Goping, and Przemyslaw Hirszel

Gliotoxin-Induced Cytotoxicity Proceeds via Apoptosis and Is Mediated by Caspases and Reactive Oxygen Species in LLC-PK1 Cells
Toxicol. Sci. 2000 54: 194-202; doi:10.1093/toxsci/54.1.194 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

Sanjiv Gupta, Richard C. Husser, Robert S. Geske, Stephen E. Welty, and Charles V. Smith

Sex Differences in Diquat-Induced Hepatic Necrosis and DNA Fragmentation in Fischer 344 Rats
Toxicol. Sci. 2000 54: 203-211; doi:10.1093/toxsci/54.1.203 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

Stéphane Rappeneau, Armelle Baeza-Squiban, Claudette Jeulin, and Francelyne Marano

Protection from Cytotoxic Effects Induced by the Nitrogen Mustard Mechlorethamine on Human Bronchial Epithelial Cells in Vitro
Toxicol. Sci. 2000 54: 212-221; doi:10.1093/toxsci/54.1.212 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John B. Morris

Uptake of Styrene in the Upper Respiratory Tract of the CD Mouse and Sprague-Dawley Rat
Toxicol. Sci. 2000 54: 222-228; doi:10.1093/toxsci/54.1.222 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ramesh Sarangapani and Anthony S. Wexler

The Role of Dispersion in Particle Deposition in Human Airways
Toxicol. Sci. 2000 54: 229-236; doi:10.1093/toxsci/54.1.229 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. Bellmann, O. Creutzenberg, C. Dasenbrock, H. Ernst, G. Pohlmann, and H. Muhle

Inhalation Tolerance Study for p-Aramid Respirable Fiber-Shaped Particulates (RFP) in Rats
Toxicol. Sci. 2000 54: 237-250; doi:10.1093/toxsci/54.1.237 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Risk Assessment:

H. A. Barton, P. J. Deisinger, J. C. English, J. M. Gearhart, W. D. Faber, T. R. Tyler, M. I. Banton, Justin Teeguarden, and M. E. Andersen

Family Approach for Estimating Reference Concentrations/Doses for Series of Related Organic Chemicals
Toxicol. Sci. 2000 54: 251-261; doi:10.1093/toxsci/54.1.251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Thomas L. Horn, Timothy D. O'Brien, Lawrence B. Schook, and Mark S. Rutherford

Acute Hepatotoxicant Exposure Induces TNFR-Mediated Hepatic Injury and Cytokine/Apoptotic Gene Expression
Toxicol. Sci. 2000 54: 262-273; doi:10.1093/toxsci/54.1.262 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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