Toxicological Sciences

Profiles In Toxicology:

W. E. Rinehart

The Origins of the American Board of Toxicology
Toxicol. Sci. 2000 54: 275-276; doi:10.1093/toxsci/54.2.275 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

William D. Pennie, Jonathan D. Tugwood, Gerry J. A. Oliver, and Ian Kimber

The Principles and Practice of Toxicogenomics: Applications and Opportunities
Toxicol. Sci. 2000 54: 277-283; doi:10.1093/toxsci/54.2.277 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

G. L. Qiao, S. K. Chang, J. D. Brooks, and J. E. Riviere

Dermatotoxicokinetic Modeling of p-Nitrophenol and Its Conjugation Metabolite in Swine following Topical and Intravenous Administration
Toxicol. Sci. 2000 54: 284-294; doi:10.1093/toxsci/54.2.284 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Wei Zheng, Hyaehwan Kim, and Qiuqu Zhao

Comparative Toxicokinetics of Manganese Chloride and Methylcyclopentadienyl Manganese Tricarbonyl (MMT) in Sprague-Dawley Rats
Toxicol. Sci. 2000 54: 295-301; doi:10.1093/toxsci/54.2.295 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kyung O. Yu, Hugh A. Barton, Deirdre A. Mahle, and John M. Frazier

In Vivo Kinetics of Trichloroacetate in Male Fischer 344 Rats
Toxicol. Sci. 2000 54: 302-311; doi:10.1093/toxsci/54.2.302 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Jacqueline H. Smith, Jason S. Isenberg, George Pugh, Jr., Lisa M. Kamendulis, David Ackley, Arthur W. Lington, and James E. Klaunig

Comparative in Vivo Hepatic Effects of Di-Isononyl Phthalate (DINP) and Related C₇–C₁₁ Dialkyl Phthalates on Gap Junctional Intercellular Communication (GJIC), Peroxisomal Beta-Oxidation (PBOX), and DNA Synthesis in Rat and Mouse Liver
Toxicol. Sci. 2000 54: 312-321; doi:10.1093/toxsci/54.2.312 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Quanxin Meng, Ting Su, Ofelia A. Olivero, Miriam C. Poirier, Xiaochu Shi, Xinxin Ding, and Vernon E. Walker

Relationships between DNA Incorporation, Mutant Frequency, and Loss of Heterozygosity at the TK Locus in Human Lymphoblastoid Cells Exposed to 3'-Azido-3'-deoxythymidine
Toxicol. Sci. 2000 54: 322-329; doi:10.1093/toxsci/54.2.322 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Nigel J. Walker, Angelika M. Tritscher, Robert C. Sills, George W. Lucier, and Christopher J. Portier

Hepatocarcinogenesis in Female Sprague-Dawley Rats following Discontinuous Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Toxicol. Sci. 2000 54: 330-337; doi:10.1093/toxsci/54.2.330 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

John C. O'Connor, Leonard G. Davis, Steven R. Frame, and Jon C. Cook

Evaluation of a Tier I Screening Battery for Detecting Endocrine-Active Compounds (EACs) Using the Positive Controls Testosterone, Coumestrol, Progesterone, and RU486
Toxicol. Sci. 2000 54: 338-354; doi:10.1093/toxsci/54.2.338 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Leslie C. Hodges, Jill S. Bergerson, Deborah S. Hunter, and Cheryl L. Walker

Estrogenic Effects of Organochlorine Pesticides on Uterine Leiomyoma Cells in Vitro
Toxicol. Sci. 2000 54: 355-364; doi:10.1093/toxsci/54.2.355 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

W. J. Fischer, B. C. Hitzfeld, F. Tencalla, J. E. Eriksson, A. Mikhailov, and D. R. Dietrich

Microcystin-LR Toxicodynamics, Induced Pathology, and Immunohistochemical Localization in Livers of Blue-Green Algae Exposed Rainbow Trout (Oncorhynchus mykiss)
Toxicol. Sci. 2000 54: 365-373; doi:10.1093/toxsci/54.2.365 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

Francis G. Murante and Thomas A. Gasiewicz

Hemopoietic Progenitor Cells Are Sensitive Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in C57BL/6J Mice
Toxicol. Sci. 2000 54: 374-383; doi:10.1093/toxsci/54.2.374 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Joseph M. Griffin, Kathleen M. Gilbert, and Neil R. Pumford

Inhibition of CYP2E1 Reverses CD4⁺ T-Cell Alterations in Trichloroethylene-Treated MRL+/+ Mice
Toxicol. Sci. 2000 54: 384-389; doi:10.1093/toxsci/54.2.384 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

B. P. Slezak, G. E. Hatch, M. J. DeVito, J. J. Diliberto, R. Slade, K. Crissman, E. Hassoun, and L. S. Birnbaum

Oxidative Stress in Female B6C3F1 Mice following Acute and Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Toxicol. Sci. 2000 54: 390-398; doi:10.1093/toxsci/54.2.390 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lianhui Tao, Siming Yang, Mi Xie, Paula M. Kramer, and Michael A. Pereira

Effect of Trichloroethylene and Its Metabolites, Dichloroacetic Acid and Trichloroacetic Acid, on the Methylation and Expression of c-Jun and c-Myc Protooncogenes in Mouse Liver: Prevention by Methionine
Toxicol. Sci. 2000 54: 399-407; doi:10.1093/toxsci/54.2.399 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

Thomas Kellner, James Sanborn, and Barry Wilson

In Vitro and in Vivo Assessment of the Effect of Impurities and Chirality on Methamidophos-Induced Neuropathy Target Esterase Aging
Toxicol. Sci. 2000 54: 408-415; doi:10.1093/toxsci/54.2.408 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Gaku Ichihara, Xiaozhong Yu, Junzoh Kitoh, Nobuyuki Asaeda, Toshihiko Kumazawa, Hisakazu Iwai, Eiji Shibata, Tetsuya Yamada, Hailan Wang, Zhenlin Xie, Kei-ichiro Maeda, Hiroko Tsukamura, and Yasuhiro Takeuchi

Reproductive Toxicity of 1-Bromopropane, a Newly Introduced Alternative to Ozone Layer Depleting Solvents, in Male Rats
Toxicol. Sci. 2000 54: 416-423; doi:10.1093/toxsci/54.2.416 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. T. Hamm, B. R. Sparrow, D. Wolf, and L. S. Birnbaum

In Utero and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters Postnatal Development of Seminal Vesicle Epithelium
Toxicol. Sci. 2000 54: 424-430; doi:10.1093/toxsci/54.2.424 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

A. O. Gamer, J. Hellwig, J. E. Doe, and R. W. Tyl

Prenatal Toxicity of Inhaled Polymeric Methylenediphenyl Diisocyanate (MDI) Aerosols in Pregnant Wistar Rats
Toxicol. Sci. 2000 54: 431-440; doi:10.1093/toxsci/54.2.431 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

Urmila P. Kodavanti, Rudolph Mebane, Allen Ledbetter, Todd Krantz, John McGee, Mette C. Jackson, Leon Walsh, Hassell Hilliard, Bai Yi Chen, Judy Richards, and Daniel L. Costa

Variable Pulmonary Responses from Exposure to Concentrated Ambient Air Particles in a Rat Model of Bronchitis
Toxicol. Sci. 2000 54: 441-451; doi:10.1093/toxsci/54.2.441 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Barbara L. Weller, Hanspeter Witschi, and Kent E. Pinkerton

Quantitation and Localization of Pulmonary Manganese Superoxide Dismutase and Tumor Necrosis Factor following Exposure to Ozone and Nitrogen Dioxide
Toxicol. Sci. 2000 54: 452-461; doi:10.1093/toxsci/54.2.452 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Risk Assessment:

Carr J. Smith, Thomas H. Fischer, and Stephen B. Sears

Environmental Tobacco Smoke, Cardiovascular Disease, and the Nonlinear Dose-Response Hypothesis
Toxicol. Sci. 2000 54: 462-472; doi:10.1093/toxsci/54.2.462 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

D. R. Smith, C. Calacsan, D. Woolard, M. Luck, J. Cremin, and N. K. Laughlin

Succimer and the Urinary Excretion of Essential Elements in a Primate Model of Childhood Lead Exposure
Toxicol. Sci. 2000 54: 473-480; doi:10.1093/toxsci/54.2.473 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey M. Charles, Abraham Tobia, and Ben van Ravenzwaay

Subchronic and Chronic Toxicological Investigations on Metiram: The Lack of a Carcinogenic Response in Rodents
Toxicol. Sci. 2000 54: 481-492; doi:10.1093/toxsci/54.2.481 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Michael E. Wyde, John Seely, George W. Lucier, and Nigel J. Walker

Toxicity of Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Diethylnitrosamine-Initiated Ovariectomized Rats Implanted with Subcutaneous 17 ß-Estradiol Pellets
Toxicol. Sci. 2000 54: 493-499; doi:10.1093/toxsci/54.2.493 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Elizabeth H. Romach, Christopher Q. Zhao, Luz María Del Razo, Mariano E. Cebrián, and Michael P. Waalkes

Studies on the Mechanisms of Arsenic-Induced Self Tolerance Developed in Liver Epithelial Cells through Continuous Low-Level Arsenite Exposure
Toxicol. Sci. 2000 54: 500-508; doi:10.1093/toxsci/54.2.500 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Judy A. Lawson, Anwar Farhood, Robert D. Hopper, Mary Lynn Bajt, and Hartmut Jaeschke

The Hepatic Inflammatory Response after Acetaminophen Overdose: Role of Neutrophils
Toxicol. Sci. 2000 54: 509-516; doi:10.1093/toxsci/54.2.509 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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