Toxicological Sciences

Profiles in Toxicology:

Hanspeter Witschi

Fritz Haber: 1868–1934
Toxicol. Sci. 2000 55: 1-2; doi:10.1093/toxsci/55.1.1 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

Jay I. Goodman, David J. Brusick, William M. Busey, Samuel M. Cohen, James C. Lamb, and Thomas B. Starr

Reevaluation of the Cancer Potency Factor of Toxaphene: Recommendations from a Peer Review Panel
Toxicol. Sci. 2000 55: 3-16; doi:10.1093/toxsci/55.1.3 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

James Huff, Po Chan, and Abraham Nyska

Is the Human Carcinogen Arsenic Carcinogenic to Laboratory Animals?
Toxicol. Sci. 2000 55: 17-23; doi:10.1093/toxsci/55.1.17 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Kevin E. Driscoll, Daniel L. Costa, Gary Hatch, Rogene Henderson, Gunter Oberdorster, Harry Salem, and Richard B. Schlesinger

Intratracheal Instillation as an Exposure Technique for the Evaluation of Respiratory Tract Toxicity: Uses and Limitations
Toxicol. Sci. 2000 55: 24-35; doi:10.1093/toxsci/55.1.24 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

William F. Heydens, Alan G. E. Wilson, Lori J. Kraus, William E. Hopkins, II, and Kathy J. Hotz

Ethane Sulfonate Metabolite of Alachlor: Assessment of Oncogenic Potential Based on Metabolic and Mechanistic Considerations
Toxicol. Sci. 2000 55: 36-43; doi:10.1093/toxsci/55.1.36 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Annette Bitsch, Nikolai Hadjiolov, Peter-Christian Klöhn, Ole Bergmann, Iris Zwirner-Baier, and Hans-Günter Neumann

Dose Response of Early Effects Related to Tumor Promotion of 2-Acetylaminofluorene
Toxicol. Sci. 2000 55: 44-51; doi:10.1093/toxsci/55.1.44 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Lloyd Dethloff, Bridget Barr, Lorelle Bestervelt, Steven Bulera, Robert Sigler, Mark LaGattuta, and Felix de la Iglesia

Gabapentin-Induced Mitogenic Activity in Rat Pancreatic Acinar Cells
Toxicol. Sci. 2000 55: 52-59; doi:10.1093/toxsci/55.1.52 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. L. Carlisle, D. E. Pritchard, J. Singh, B. M. Owens, L. J. Blankenship, J. M. Orenstein, and S. R. Patierno

Apoptosis and P53 Induction in Human Lung Fibroblasts Exposed to Chromium (VI): Effect of Ascorbate and Tocopherol
Toxicol. Sci. 2000 55: 60-68; doi:10.1093/toxsci/55.1.60 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

S. Miller, D. Kennedy, J. Thomson, F. Han, R. Smith, N. Ing, J. Piedrahita, and D. Busbee

A Rapid and Sensitive Reporter Gene that Uses Green Fluorescent Protein Expression to Detect Chemicals with Estrogenic Activity
Toxicol. Sci. 2000 55: 69-77; doi:10.1093/toxsci/55.1.69 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Alan Hood and Curtis D. Klaassen

Differential Effects of Microsomal Enzyme Inducers on in Vitro Thyroxine (T₄) and Triiodothyronine (T₃) Glucuronidation
Toxicol. Sci. 2000 55: 78-84; doi:10.1093/toxsci/55.1.78 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Environmental Toxicology:

A. M. Doi, Z. Lou, E. Holmes, C.-L. J. Li, C. S. Venugopal, M. O. James, and K. M. Kleinow

Effect of Micelle Fatty Acid Composition and 3,4,3',4'-Tetrachlorobiphenyl (TCB) Exposure on Intestinal [¹⁴C]-TCB Bioavailability and Biotransformation in Channel Catfish in Situ Preparations
Toxicol. Sci. 2000 55: 85-96; doi:10.1093/toxsci/55.1.85 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

S. L. Chen, L. Cai, Q. Y. Meng, S. Xu, H. Wan, and S. Z. Liu

Low-Dose Whole-Body Irradiation (LD-WBI) Changes Protein Expression of Mouse Thymocytes: Effect of a LD-WBI-Enhanced Protein RIP10 on Cell Proliferation and Spontaneous or Radiation-Induced Thymocyte Apoptosis
Toxicol. Sci. 2000 55: 97-106; doi:10.1093/toxsci/55.1.97 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

In Vitro Toxicology and Alternative Testing:

Shawn D. Seidel, Violet Li, Greg M. Winter, William J. Rogers, Eugenio I. Martinez, and Michael S. Denison

Ah Receptor-Based Chemical Screening Bioassays: Application and Limitations for the Detection of Ah Receptor Agonists
Toxicol. Sci. 2000 55: 107-115; doi:10.1093/toxsci/55.1.107 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

Gaku Ichihara, Junzoh Kitoh, Xiaozhong Yu, Nobuyuki Asaeda, Hisakazu Iwai, Toshihiko Kumazawa, Eiji Shibata, Tetsuya Yamada, Hailan Wang, Zhenlin Xie, and Yasuhiro Takeuchi

1-Bromopropane, an Alternative to Ozone Layer Depleting Solvents, Is Dose-Dependently Neurotoxic to Rats in Long-Term Inhalation Exposure
Toxicol. Sci. 2000 55: 116-123; doi:10.1093/toxsci/55.1.116 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Quan Zheng, Kenneth Olivier, Yen K. Won, and Carey N. Pope

Comparative Cholinergic Neurotoxicity of Oral Chlorpyrifos Exposures in Preweanling and Adult Rats
Toxicol. Sci. 2000 55: 124-132; doi:10.1093/toxsci/55.1.124 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

John F. Bowyer, Glenn D. Newport, William Slikker, Jr., Bobby Gough, Sherry A. Ferguson, and John Tor-Agbidye

An Evaluation of l-Ephedrine Neurotoxicity with Respect to Hyperthermia and Caudate/Putamen Microdialysate Levels of Ephedrine, Dopamine, Serotonin, and Glutamate
Toxicol. Sci. 2000 55: 133-142; doi:10.1093/toxsci/55.1.133 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Eve Mylchreest, Duncan G. Wallace, Russell C. Cattley, and Paul M. D. Foster

Dose-Dependent Alterations in Androgen-Regulated Male Reproductive Development in Rats Exposed to Di(n-butyl) Phthalate during Late Gestation
Toxicol. Sci. 2000 55: 143-151; doi:10.1093/toxsci/55.1.143 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Cynthia J. Wolf, Gerald A. LeBlanc, Joseph S. Ostby, and L. Earl Gray, Jr.

Characterization of the Period of Sensitivity of Fetal Male Sexual Development to Vinclozolin
Toxicol. Sci. 2000 55: 152-161; doi:10.1093/toxsci/55.1.152 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

Hanin Abdel-Haq, Maura Palmery, Maria Grazia Leone, Luciano Saso, and Bruno Silvestrini

Relaxant Effects of Aflatoxins on Isolated Guinea Pig Trachea
Toxicol. Sci. 2000 55: 162-170; doi:10.1093/toxsci/55.1.162 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Ellen J. O'Flaherty

Modeling Normal Aging Bone Loss, with Consideration of Bone Loss in Osteoporosis
Toxicol. Sci. 2000 55: 171-188; doi:10.1093/toxsci/55.1.171 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

D. M. Schiavo and P. Bentley

Ocular Changes in Beagle Dogs following Oral Administration of CGS 24565, a Potential Hypolipidemic Agent
Toxicol. Sci. 2000 55: 189-194; doi:10.1093/toxsci/55.1.189 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Angélique P. J. M. van Birgelen, Billy J. Chou, Roger A. Renne, Sondra L. Grumbein, Joe H. Roycroft, James R. Hailey, and John R. Bucher

Effects of Glutaraldehyde in a 2-Year Inhalation Study in Rats and Mice
Toxicol. Sci. 2000 55: 195-205; doi:10.1093/toxsci/55.1.195 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Hironobu Ishiyama, Niel C. Hoglen, and I. Glenn Sipes

Diethyldithiocarbamate Enhances Production of Nitric Oxide and TNF- by Lipopolysaccharide-Stimulated Rat Kupffer Cells
Toxicol. Sci. 2000 55: 206-214; doi:10.1093/toxsci/55.1.206 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jeffrey S. Smith, Orest T. Macina, Nancy B. Sussman, Michael I. Luster, and Meryl H. Karol

A Robust Structure-Activity Relationship (SAR) Model for Esters that Cause Skin Irritation in Humans
Toxicol. Sci. 2000 55: 215-222; doi:10.1093/toxsci/55.1.215 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sultan S. Habeebu, Jie Liu, Yaping Liu, and Curtis D. Klaassen

Metallothionein-Null Mice Are More Sensitive than Wild-Type Mice to Liver Injury Induced by Repeated Exposure to Cadmium
Toxicol. Sci. 2000 55: 223-232; doi:10.1093/toxsci/55.1.223 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

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