Toxicological Sciences

Toxicological Highlight:

Stephen Safe

Bisphenol A and Related Endocrine Disruptors
Toxicol. Sci. 2000 56: 251-252; doi:10.1093/toxsci/56.2.251 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Ken M. Brown and Andriana D. Papaconstantinou

Response
Toxicol. Sci. 2000 56: 252; doi:10.1093/toxsci/56.2.252 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Profiles in Toxicology:

Hanspeter Witschi

Gerhard Zbinden, 1924–1993
Toxicol. Sci. 2000 56: 253-254; doi:10.1093/toxsci/56.2.253 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Forum:

Michael P. Waalkes, Donald A. Fox, J. Christopher States, Steven R. Patierno, and Michael J. McCabe, Jr.

Metals and Disorders of Cell Accumulation: Modulation of Apoptosis and Cell Proliferation
Toxicol. Sci. 2000 56: 255-261; doi:10.1093/toxsci/56.2.255 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

Biotransformation and Toxicokinetics:

Benjamin B. Hayes, Aliakbar Afshari, Lyndell Millecchia, Patsy A. Willard, Stephen P. Povoski, and B. Jean Meade

Evaluation of Percutaneous Penetration of Natural Rubber Latex Proteins
Toxicol. Sci. 2000 56: 262-270; doi:10.1093/toxsci/56.2.262 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

B. J. Collins, T. B. Grizzle, and J. K. Dunnick

Toxicokinetics of Phenolphthalein in Male and Female Rats and Mice
Toxicol. Sci. 2000 56: 271-281; doi:10.1093/toxsci/56.2.271 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

S. E. George, G. M. Nelson, A. E. Swank, L. R. Brooks, K. Bailey, M. George, and A. DeAngelo

The Disinfection By-Products Dichloro-, Dibromo-, and Bromochloroacetic Acid Impact Intestinal Microflora and Metabolism in Fischer 344 Rats upon Exposure in Drinking Water
Toxicol. Sci. 2000 56: 282-289; doi:10.1093/toxsci/56.2.282 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Kohji Shimoda, Toshiko Ikeda, Satoshi Okawara, and Michiyuki Kato

Possible Relationship between Phototoxicity and Photodegradation of Sitafloxacin, a Quinolone Antibacterial Agent, in the Auricular Skin of Albino Mice
Toxicol. Sci. 2000 56: 290-296; doi:10.1093/toxsci/56.2.290 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Carcinogenicity:

Mari Iida, Hijiri Iwata, Hiroyuki Inoue, Makoto Enomoto, Nobuyuki Horie, and Keiichi Takeishi

Correlation between Bcl-2 Overexpression and H-ras Mutation in Naturally Occurring Hepatocellular Proliferative Lesions of the B6C3F1 Mouse
Toxicol. Sci. 2000 56: 297-302; doi:10.1093/toxsci/56.2.297 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Haizhou Zhang, Yong Xu, Lisa M. Kamendulis, and James E. Klaunig

Morphological Transformation by 8-Hydroxy-2'-deoxyguanosine in Syrian Hamster Embryo (SHE) Cells
Toxicol. Sci. 2000 56: 303-312; doi:10.1093/toxsci/56.2.303 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Liyan Zhang, Diann L. Weddle, Paul E. Thomas, Beiyao Zheng, Andre Castonguay, Hildegard M. Schuller, and Mark Steven Miller

Low Levels of Expression of Cytochromes P-450 in Normal and Cancerous Fetal Pancreatic Tissues of Hamsters Treated with NNK and/or Ethanol
Toxicol. Sci. 2000 56: 313-323; doi:10.1093/toxsci/56.2.313 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Endocrine Toxicology:

Parikshit C. Das, William K. McElroy, and Ralph L. Cooper

Differential Modulation of Catecholamines by Chlorotriazine Herbicides in Pheochromocytoma (PC12) Cells in Vitro
Toxicol. Sci. 2000 56: 324-331; doi:10.1093/toxsci/56.2.324 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Andriana D. Papaconstantinou, Thomas H. Umbreit, Benjamin R. Fisher, Peter L. Goering, Nicholas T. Lappas, and Ken M. Brown

Bisphenol A-Induced Increase in Uterine Weight and Alterations in Uterine Morphology in Ovariectomized B6C3F1 Mice: Role of the Estrogen Receptor
Toxicol. Sci. 2000 56: 332-339; doi:10.1093/toxsci/56.2.332 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Immunotoxicology:

David M. Shepherd, Erica A. Dearstyne, and Nancy I. Kerkvliet

The Effects of TCDD on the Activation of Ovalbumin (OVA)-Specific DO11.10 Transgenic CD4⁺ T cells in Adoptively Transferred Mice
Toxicol. Sci. 2000 56: 340-350; doi:10.1093/toxsci/56.2.340 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Molecular and Genetic Toxicology:

King-Thom Chung, Ssu-Ching Chen, Tit Yee Wong, Ying-Sing Li, Cheng-I Wei, and Ming W. Chou

Mutagenicity Studies of Benzidine and Its Analogs: Structure-Activity Relationships
Toxicol. Sci. 2000 56: 351-356; doi:10.1093/toxsci/56.2.351 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Sheryl R. Krig and Robert H. Rice

TCDD Suppression of Tissue Transglutaminase Stimulation by Retinoids in Malignant Human Keratinocytes
Toxicol. Sci. 2000 56: 357-364; doi:10.1093/toxsci/56.2.357 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Neurotoxicology:

D. Alan Warren, Scott E. Bowen, W. B. Jennings, Cham E. Dallas, and Robert L. Balster

Biphasic Effects of 1,1,1-Trichloroethane on the Locomotor Activity of Mice: Relationship to Blood and Brain Solvent Concentrations
Toxicol. Sci. 2000 56: 365-373; doi:10.1093/toxsci/56.2.365 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Reproductive and Developmental Toxicology:

Jack Z. Yang, Sanjay K. Agarwal, and Warren G. Foster

Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey
Toxicol. Sci. 2000 56: 374-381; doi:10.1093/toxsci/56.2.374 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Jamie C. Benedict, Tien-Min Lin, I. K. Loeffler, Richard E. Peterson, and Jodi A. Flaws

Physiological Role of the Aryl Hydrocarbon Receptor in Mouse Ovary Development
Toxicol. Sci. 2000 56: 382-388; doi:10.1093/toxsci/56.2.382 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

C. Lambright, J. Ostby, K. Bobseine, V. Wilson, A. K. Hotchkiss, P. C. Mann, and L. E. Gray, Jr.

Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide that Produces Reproductive Malformations in Male Rats
Toxicol. Sci. 2000 56: 389-399; doi:10.1093/toxsci/56.2.389 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

J. Odum and J. Ashby

Neonatal Exposure of Male Rats to Nonylphenol Has No Effect on the Reproductive Tract
Toxicol. Sci. 2000 56: 400-404; doi:10.1093/toxsci/56.2.400 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Respiratory Toxicology:

Carl J. Johnston, Kevin E. Driscoll, Jacob N. Finkelstein, R. Baggs, Michael A. O'Reilly, Janet Carter, Robert Gelein, and Günter Oberdörster

Pulmonary Chemokine and Mutagenic Responses in Rats after Subchronic Inhalation of Amorphous and Crystalline Silica
Toxicol. Sci. 2000 56: 405-413; doi:10.1093/toxsci/56.2.405 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Safety Evaluation:

Douglas A. Keller, Gerald L. Kennedy, Jr., Paul E. Ross, David P. Kelly, and Glenn S. Elliott

Toxicity of Tetrafluoroethylene and S-(1,1,2,2-tetrafluoroethyl)-L-cysteine in Rats and Mice
Toxicol. Sci. 2000 56: 414-423; doi:10.1093/toxsci/56.2.414 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

M. K. Lee, B. W. H. Cheng, C. T. Che, and D. P. H. Hsieh

Cytotoxicity Assessment of Ma-huang (Ephedra) under Different Conditions of Preparation
Toxicol. Sci. 2000 56: 424-430; doi:10.1093/toxsci/56.2.424 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Systems Toxicology:

Morris Cranmer, Shirley Louie, Richard H. Kennedy, Philip A. Kern, and Vivian A. Fonseca

Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Is Associated with Hyperinsulinemia and Insulin Resistance
Toxicol. Sci. 2000 56: 431-436; doi:10.1093/toxsci/56.2.431 [Abstract] [FREE Full Text] [PDF] [Request Permissions]  

Letters to the Editor:

Paul H. Dugard and Raymond Runyan

Toxicol. Sci. 2000 56: 437-438; doi:10.1093/toxsci/56.2.437 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

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